Relationships between liver function changes and peripheral neuropathy in patients with type 2 diabetes

Objective To study the changes of liver function of type 2 diabetes patients with diabetic peripheral neuropathy (DPN). Methods The levels of ALT,AST and γ-GT of 100 cases of T2DM with DPN (DPN group),100 cases of T2DM without DPN (non-DPN group),and 200 healthy control subjects (control group) were tested by biochemical test. Results The cases with elevated ALT and γ-GT both in DPN group and non-DPN group were more than that in the control group,and the rate was more higher in the DPN group as compared with non-DPN group.The difference in the cases with elevated AST was not significant among the three groups.The levels of ALT and γ-GT both in DPN and non-DPN group were higher than that in the control group (P<0.05),while the levels of ALT and γ-GT in DPN group was higher than that in the non-DPN group (P<0.05),with a tendency to rise as the disease got worse.The multiple logistic regression showed that the levels of ALT and γ-GT were the risk factors for T2DM combined with DPN. Conclusion The function of liver is closely related with DPN in patients with T2DM.To monitor and control the levels of ALT and γ-GT will be beneficial for the effective intervention and improvement of the outcome of DPN patients.