The correlation between diffusion weighted imaging with cervical cancer cell proliferation activity of PCNA and Ki-67

Objective To evaluate the difference of diffusion weighted imaging (DWI) ADC value and rADC value of different degree of differentiation cervical cancer and correlation with cervical cancer cell proliferation activity (PCNA and Ki-67). Methods Forty patients with pathological diagnosis for cervical cancer were selected for this study.Preoperative magnetic resonance imaging (MRI) and DWI was performed before operation.Meanwhile,the PCNA and Ki-67 immunohistochemical staining were performed.The expression of PCNA and Ki-67 in different differentiation degree of cervical cancer were analysed by analysis of variance,and the correlation with ADC and the rADC value were also analysed by Pearson correlation methods.SPSS 20.0 was used to calculated the relevant data and significance was set at <0.05. Results The ADC values and rADC value in poorly differentiated group is less than high differentiation group,and the difference was statistically significant (t=2.118,P<0.05).There was no significant difference between the poorly differentiated group and middle differentiated group (P>0.05).With the degree of differentiation is reduced,the expression of PCNA and Ki-67 is increased.With the increase of the degree of expression of PCNA and Ki-67,ADC values and the rADC value decreased,the difference had statistical significance (P<0.05).Pearson correlation test showed that ADC values to be inversely associated with the degree of Ki-67 and PCNA expression. Conclusion DWI imaging and the ADC,rADC value measurement for cervical cancer can help to evaluate the cervical cancer with different pathological level and has the potential to be a non-invasive method for identifying tumor proliferation.