Clinical study of Mudan granule combined with Mecobalamin in treatment of diabetic peripheral neuropathy

Objective To investigate the clinical effect of Mudan granule combined Mecobalamin on diabetic peripheral neuropathy. Methods Ninety-eight cases of diabetic peripheral neuropathy patients were randomly divided into 2 groups (49 cases in each group).The control group was given mecobalamin,and observation group was given Mudan granule based on control group.Before and after treatment,serum biochemical parameters[serum total cholesterol (TC),triglyceride (TG),whole blood high shear viscosity (HBV),whole blood low shear viscosity (LBV)],clinical symptom score (Limb numbness and tingling sensation,acral temperature sensory disturbance,acral reflex sensitivity and limb weakness),nerve conduction velocity[motor nerve conduction velocity (MNCV) and sensory conduction velocity (SNCV) of median nerve,common peroneal nerve and anterior tibial nerve]of two groups were detected,and the clinical effect of two groups were accounted. Results After treatment,the TC,TG,HBV and LBV levels of two groups were significantly reduced (P<0.05);and TC,TG,HBV and LBV levels of observation group were significantly lower than control group (P<0.05).After treatment,limb numbness and tingling sensation,acral temperature sensory disturbance,acral reflex sensitivity and limb weakness of two groups were significantly reduced (P<0.05);and limb numbness and tingling sensation,acral temperature sensory disturbance,acral reflex sensitivity and limb weakness of observation group were significantly lower than control group (P<0.05).After treatment,median nerve,common peroneal nerve and anterior tibial nerve MNCV and SNCV of two groups were significantly increased (P<0.05);and median nerve,common peroneal nerve and anterior tibial nerve MNCV and SNCV of observation group were significantly higher than control group (P<0.05).The total effective rate of the observation group was 89.8%,which was significantly higher than control group (73.5%,P<0.05). Conclusion Mudan granule combined Mecobalamin could significantly improve the clinical symptoms of diabetic peripheral neuropathy with satisfactory effect.