The influence of tegafur combined with capecitabine on inflammatory factors and lymphocyte function of patients with gallbladder cancer

Objective Lymphoid cells and inflammatory factors in patients with gallbladder were abnormal expression,this research study the influence of tegafur combined capecitabine on inflammatory factors and lymphocyte function of patients with gallbladder cancer,to explore its clinical mechanism. Methods Eighty-four cases of patients with gallbladder cancer were divided into experimental group (n=42) and control group (n=42) according to random number table method.The control group treated with oral capecitabine,1.5 g/m²,2 times/day.The experimental group was given tegafur 50 mg/m²,2 times/day combined with oral capecitabine,1.5 g/m²,2 times/day.After 8 weeks,the clinical efficacy,clinical benefit,toxic and side reaction of two groups of patients would be observed.Serum TNF alpha,IL-6,IL-8 levels of inflammatory factors were detected by ELISA.T cell subgroup CD4⁺,CD8⁺ cells were detected by Flow cytometry.The clinical effect,inflammatory factors and cellular function were analyzed. Results The total effective rate 52.38%(22/42) of experimental group,and the control group was 33.33%(14/42),the differences were no statistically significant of rank sum test (P>0.05).The tumor control rate 78.57%(33/42) of experimental group was higher than the control group 57.14%(24/42),and the differences were statistically significant (P<0.05).Eight weeks after treatment,the levels of TNF alpha),IL-6 and IL-8 in the experimental group were lower than the control group,the differences were statistically significant (P<0.05).The T cell subgroup CD4⁺,CD8⁺ cells in the experimental group were higher than the control group,the differences were statistically significant (P<0.05).Two groups of patients main adverse reactions were rash,nausea,vomiting,liver function damage.There was no statistically significant difference between the two groups (P>0.05). Conclusion Treatment methods of tegafur combined capecitabine for Patients with gallbladder had good recent curative effect,can reduce inflammatory reaction,enhance the body's immune function,had a lighter side reaction.It was Worthy of clinical popularization and application.