Clinical observation of classic prescriptions Shegan Mahuang decoction on cough after infection patients with wind-cold stay in the lung

Objective To investigate the clinical effect of classic prescriptions Shegan Mahuang decoction on cough after infection patients with wind-cold stay in the lung. Methods Sixty cases of cough after infection patients with wind-cold stay in the lung in our hospital from November,2014 to August,2015 were randomly divided into 2 groups,each 30 cases.The control group was given Fufang Methamidophos Capsule,while the treatment group was given Shegan Mahuang decoction.The clinical TCM syndrome score,Leslie cough quality of life questionnaire (LCQ),symptom improvement time and clinical effect of both groups were analyzed to evaluate the efficacy of Shegan Mahuang decoction.The inflammatory factors (TNF-α,IL-4),inflammatory mediators[substance P (SP) and neurokinin A (NKA)]in sputum of both groups were analyzed. Results After the treatment,the TCM syndrome score of the two groups were significantly reduced (P<0.05),and the TCM syndrome score of the treatment group was significantly lower than that in the control group (P<0.05).After the treatment,the LCQ indicators of the two groups were significantly increased (P<0.05),and the LCQ indicators of the treatment group was significantly higher than that in the control group (P<0.05).After the treatment,symptom onset time and symptom disappearance time of the treatment group were significantly lower than that in the control group (P<0.05).The total effective rate of the treatment group was 93.3%,which was significantly higher than 76.7% in the control group (P<0.05).After the treatment,the TNF-α and IL-4 levels of the two groups were significantly reduced (P<0.05),and the TNF-α and IL-4 levels of the treatment group was significantly lower than those in the control group (P<0.05).After the treatment,the SP and NKA levels of the two groups were significantly reduced (P<0.05),and the SP and NKA levels of the treatment group was significantly lower than those in the control group (P<0.05). Conclusion Shegan Mahuang decoction could effectively improve the clinical symptoms and life quality of cough after infection patients with wind-cold stay in the lung,and its treatment mechanism might be related to the improvement of airway neurogenic inflammation.