Effects of intravenous thrombolysis with alteplase on neurological function,inflammation and oxidative stress in patients with acute cerebral infarction

Objective To investigate the effects of intravenous thrombolysis with alteplase on neurological function, inflammation and oxidative stress in patients with acute cerebral infarction. Methods A total of 142 cases of acute cerebral infarction patients in our hospital from January, 2013 to June, 2016 were retrospectively analyzed. The patients in the observation group (79 cases) were received intravenous alteplase therapy, while the patients in the control group (63 cases) received routine therapy. After the treatment, the neurological function[National Institute of Health Stroke Scale (NIHSS), Modified Rankin 's Scale (mRS)], inflammation[hypersensitive C-reactive protein (hs-CRP), interleukin-1β (IL-1β), tumor necrosis factor (TNF-α)], oxidative stress[superoxide dismutase (SOD), malonaldehyde (MDA), glutathione peroxidase (GSH-px)], and clinical effect of the two groups were compared. Results After the treatment, NIHSS levels of the observation group and control group were significantly reduced (P < 0. 05), and NIHSS level of the observation group was significantly lower than that of control group (P < 0. 05). After the treatment, mRS level of the observation group was significantly lower than that of the control group (P < 0. 05). After the treatment, hs-CRP, IL-1β and TNF-α levels of the observation group and control group were significantly reduced (P < 0. 05), and hs-CRP, IL-1β and TNF-α levels of the observation group were significantly lower than that of the control group (P < 0. 05). After the treatment, SOD and GSH-px levels of the observation group and control group were significantly increase (P < 0. 05), and MDA levels of the observation group and control group were significantly reduced (P < 0. 05); and SOD and GSH-px levels of the observation group were significantly higher than that of the control group (P < 0. 05), MDA level of the observation group was significantly lower than that of the control group (P < 0. 05). The total effective rate of the observation group was 81. 0%, significantly higher than that (63. 5%) of control group (P < 0. 05). Conclusion Intravenous Alteplase thrombolysis could improve the neurological function, inflammation and oxidative stress in patients with acute cerebral infarction.