Influence of acetylcysteine combined glucocorticoids on immune function and inflammation of patients with severe asthma

Objective To investigate the clinical effects of acetylcysteine combined glucocorticoids on severe asthma and its influence on the immune function and inflammation, respiratory of patients. Methods Total 70 patients with severe asthma were randomly divided into two groups, with 35 cases in each group. The patients in the control group were given corticosteroids, while the patients in the observation group were given acetylcysteine combined glucocorticoids. Before and after the treatment, the immune function, inflammatory cytokines, respiratory function of the patients in the two groups were detected and the clinical efficacy was assessed. Results After the treatment, CD3, CD4, CD4/CD8, IgA, IgG and IgM levels of both groups were significantly increased (P < 0. 05), CD8 levels of both groups were significantly decreased (P <0. 05); CD3, CD4, CD4/CD8, IgA, IgG and IgM levels of the observation group were significantly higher than those of the control group (P < 0. 05), CD8 level of the observation group was significantly lower than that of the control group (P <0. 05). After the treatment, TNF-α, hs-CRP and IL-8 levels of both groups were significantly decreased (P < 0. 05), and TNF-α, hs-CRP and IL-8 levels of the observation group were significantly lower than those of the control group (P <0. 05). After the treatment, PaO₂, FVC, FEV1, FEV1%, FEV1/FVC of the two groups were significantly increased (P <0. 05), PaCO₂ levels of both groups were significantly decreased (P < 0. 05); PaO₂, FVC, FEV1, FEV1%, FEV1/FVC levels of the observation group were significantly higher than those of the control group (P < 0. 05), PaCO₂ level of the observation group was significantly lower than that of the control group (P < 0. 05). The total effective rate in the observation group was 91. 3%, which was significantly higher than that in the control group (74. 3%, P < 0. 05). Conclusion Acetylcysteine combined glucocorticoids could significantly improve immune function, inflammation, respiratory function of severe asthma patients, with satisfaction treatment.