Abstract: Objective To investigate the clinical effects of less invasive stabilization systems (LISS) assisted with arthroscopy for tibial plateau fracture. Methods A retrospective analysis of 50 patients with tibial plateau fracture who were followed up for 6 months or more in our hospital from July, 2013 to January, 2015 was conducted.The exploration and repair of arthroscopic meniscus, ligaments and other soft tissue injury were attempted to implement with arthroscopy, and all the cases underwent joint reduction and were treated with LISS assisted with arthroscopy.The postoperative functional exercises were done step-by-step.The complications, joint range of motion, fracture healing time and Rasmussen knee functional score were evaluated. Results Six months after the operation, 3 cases were with fracture malunion, 2 cases with incision necrosis or infection.The mean knee joint ROM was (93.4 ±7.8) at extension and (3.9 ±1.8) at flexion.The fracture healing time were 2.5-7.0 months, with an average of (3.8 ±1.1) months.Rasmussen knee functional score showed that the rate of excellent and good was 88%. Conclusion Less invasive stabilization systems assisted with arthroscopy for tibial plateau fracture can proceed fracture reduction with the advantage of better visual field, fewer complications and less damage and satisfactory restoration, which deserves clinical expansion.