中华全科医学

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Analysis on the characteristics of middle cerebral arterial plaque in young and middle-aged patients with acute ischemic cerebrovascular disease

SONG Jian-long, WANG Zi, WEI Jian-lin, LIU Chang, HU Wei, XIA Cheng-yu, ZHU Yu-you

Objective To study the characteristics of middle cerebral artery plaques in young and middle-aged adults with acute ischemic cerebrovascular disease using high-resolution magnetic resonance vessel wall imaging. Methods We collected 74 young and middle-aged patients with acute ischemic stroke or transient ischemic attack hospitalised from June 2018 to February 2020 using high-resolution magnetic resonance imaging to evaluate the location and nature of plaques and to compare the location distribution characteristics of symptomatic and asymptomatic middle cerebral arteries and plaques of different properties. Results There were 74 patients, including 62 cases of intracranial atherosclerotic plaque. A total of 124 middle cerebral arteries were scanned by magnetic resonance imaging in 62 patients, of which 48 were symptomatic side vessel roots (38.7%) and 76 were non-symptomatic lateral vessels (61.3%). There were 96 plaques, 39 stable plaques (40.6%), 57 unstable plaques (59.4%), 16 superior plaques (16.7%), 38 inferior plaques (39.6%), 10 dorsal plaques (10.4%) and 32 ventral plaques (33.3%). There were 41 and 16 symptomatic and non-symptomatic central cerebral artery unstable plaques (P < 0.01); stable plaques and unstable plaque locations (ventral 10 vs. 22, dorsal 2 vs. 8, superior 5 vs. 11, inferior side 22 vs. 16, all P < 0.05); symptomatic side and non-symptomatic middle cerebral artery plaque location (ventral 16 vs. 16, dorsal 6 vs. 4, superior 9 vs. 7, inferior 14 vs. 24, all P < 0.05). Conclusion The middle cerebral artery plaques in young and middle-aged patients with acute ischemic cerebrovascular disease are mainly distributed in the lower and ventral side of the blood vessels, and the properties of symptomatic plaques are mostly unstable plaques, which tend to be distributed in the ventral, dorsal and upper side of the middle cerebral artery.

Effects of Annexin A1 on inflammatory response and collagen deposition of lung fibroblast

CAI Xin, LI Yan-yu, SU Guo-mei, LYU Qiu-rong, LAI Tian-wen

Objective To investigate the effects of Annexin A1 on inflammatory response, proliferation and collagen deposition of pulmonary fibroblasts. Methods The primary lung fibroblasts of C57/BL6 mice were isolated. After 24 or 48 hours of intervention with different concentrations of Annexin A1, the expression of inflammatory factors, cell proliferation and collagen deposition were detected. C57/BL6 mice were randomly divided into control group and Annexin A1 intervention group according to the random number table method, with 6-8 mice in each group. Each mouse in the Annexin A1 intervention group was instilled with mouse recombinant Annexin A1 (1 μg/50 μL) into the trachea, and each mouse in the control group was instilled with 50 μL saline. After continuous intervention for 7 days, mice were sacrificed for measurement. Inflammatory factors, collagen Ⅲ and airway smooth muscle actin (α-SMA) were detected. Results Inflammatory cytokines (IL-6, IL-8), proliferation, collagen Ⅲ, and α-SMA were significantly increased in the Annexin A1 intervention group compared with the control group (all P < 0.05). Compared with control mice, the total number of cells in the alveolar lavage fluid of the Annexin A1 intervention group [(2.91±0.26)×10⁴/mL vs. (7.03±0.48)×10⁴ /mL, t=7.432, P=0.008] and the number of neutrophils [(0.12±0.04)×10⁴/mL vs. (1.01±0.05)×10⁴/mL, t=13.810, P < 0.001] were significantly increased, and the expression of inflammatory cytokines, collagen deposition, and smooth muscle were also significantly increased (all P < 0.05). Conclusion Annexin A1 induces inflammation, proliferation and collagen deposition in the lung fibroblasts, suggesting that Annexin A1 maybe involved in the pathogenesis of airway remodeling.

About Journal

Founded in 2003， monthly

Responsible Institution：National Health Commission of the People's Republic of China

Sponsor：Chinese Preventive Medicine Association, Anhui General Medicine Association

Chief Editor：WANG Fu-sheng

ISSN 1674-4152

CN 11-5710/R

Publishing：Magazine House of Chinese Journal of General Practice

Domestic Subscription：Local Post Office, China

Code Number：26-200

Overseas Distributor：China International Book Trading Corporation (P.O.Box 399 Beijing, China, 100044)

Distribution Number：BM1857

Articles in press have been peer-reviewed and accepted, which are not yet assigned to volumes /issues, but are citable by Digital Object Identifier (DOI).

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