中华全科医学

中国科技核心期刊
中国学术期刊（光盘版）全文收录期刊
中国生物医学核心期刊
中国期刊全文数据库收录期刊
国家卫生计生委首届优秀期刊
中国学术期刊综合评价数据库统计源期刊
学位与研究生教育重要期刊
中国引文数据库全文收录期刊

GeekPark

WeChat

Submission System

Author Peer Review Editorial Entry

通知！关于《中华全科医学》官方网站全面改版

　　《中华全科医学》杂志官方网站从2022年3月1日全新改版，感谢各位作者、读者长期以来对本刊的大力支持，在新版网站使用过程中遇到的问题请致电0552-3051890反馈。

Analysis on the characteristics of middle cerebral arterial plaque in young and middle-aged patients with acute ischemic cerebrovascular disease

SONG Jian-long, WANG Zi, WEI Jian-lin, LIU Chang, HU Wei, XIA Cheng-yu, ZHU Yu-you

Objective To study the characteristics of middle cerebral artery plaques in young and middle-aged adults with acute ischemic cerebrovascular disease using high-resolution magnetic resonance vessel wall imaging. Methods We collected 74 young and middle-aged patients with acute ischemic stroke or transient ischemic attack hospitalised from June 2018 to February 2020 using high-resolution magnetic resonance imaging to evaluate the location and nature of plaques and to compare the location distribution characteristics of symptomatic and asymptomatic middle cerebral arteries and plaques of different properties. Results There were 74 patients, including 62 cases of intracranial atherosclerotic plaque. A total of 124 middle cerebral arteries were scanned by magnetic resonance imaging in 62 patients, of which 48 were symptomatic side vessel roots (38.7%) and 76 were non-symptomatic lateral vessels (61.3%). There were 96 plaques, 39 stable plaques (40.6%), 57 unstable plaques (59.4%), 16 superior plaques (16.7%), 38 inferior plaques (39.6%), 10 dorsal plaques (10.4%) and 32 ventral plaques (33.3%). There were 41 and 16 symptomatic and non-symptomatic central cerebral artery unstable plaques (P < 0.01); stable plaques and unstable plaque locations (ventral 10 vs. 22, dorsal 2 vs. 8, superior 5 vs. 11, inferior side 22 vs. 16, all P < 0.05); symptomatic side and non-symptomatic middle cerebral artery plaque location (ventral 16 vs. 16, dorsal 6 vs. 4, superior 9 vs. 7, inferior 14 vs. 24, all P < 0.05). Conclusion The middle cerebral artery plaques in young and middle-aged patients with acute ischemic cerebrovascular disease are mainly distributed in the lower and ventral side of the blood vessels, and the properties of symptomatic plaques are mostly unstable plaques, which tend to be distributed in the ventral, dorsal and upper side of the middle cerebral artery.

Effects of Annexin A1 on inflammatory response and collagen deposition of lung fibroblast

CAI Xin, LI Yan-yu, SU Guo-mei, LYU Qiu-rong, LAI Tian-wen

Objective To investigate the effects of Annexin A1 on inflammatory response, proliferation and collagen deposition of pulmonary fibroblasts. Methods The primary lung fibroblasts of C57/BL6 mice were isolated. After 24 or 48 hours of intervention with different concentrations of Annexin A1, the expression of inflammatory factors, cell proliferation and collagen deposition were detected. C57/BL6 mice were randomly divided into control group and Annexin A1 intervention group according to the random number table method, with 6-8 mice in each group. Each mouse in the Annexin A1 intervention group was instilled with mouse recombinant Annexin A1 (1 μg/50 μL) into the trachea, and each mouse in the control group was instilled with 50 μL saline. After continuous intervention for 7 days, mice were sacrificed for measurement. Inflammatory factors, collagen Ⅲ and airway smooth muscle actin (α-SMA) were detected. Results Inflammatory cytokines (IL-6, IL-8), proliferation, collagen Ⅲ, and α-SMA were significantly increased in the Annexin A1 intervention group compared with the control group (all P < 0.05). Compared with control mice, the total number of cells in the alveolar lavage fluid of the Annexin A1 intervention group [(2.91±0.26)×10⁴/mL vs. (7.03±0.48)×10⁴ /mL, t=7.432, P=0.008] and the number of neutrophils [(0.12±0.04)×10⁴/mL vs. (1.01±0.05)×10⁴/mL, t=13.810, P < 0.001] were significantly increased, and the expression of inflammatory cytokines, collagen deposition, and smooth muscle were also significantly increased (all P < 0.05). Conclusion Annexin A1 induces inflammation, proliferation and collagen deposition in the lung fibroblasts, suggesting that Annexin A1 maybe involved in the pathogenesis of airway remodeling.

About Journal

Founded in 2003， monthly

Sponsor：National Health Commission

Sponsor：China Preventive Medicine Association, Anhui General Medical Association

Chief Editor：Alex wang

ISSN 1674-4152

CN 11-5710/R

Publish：Chinese Journal of General Practice

Domestic Distribution：Bengbu Post Offices

Overseas Distributor：China International Book Trading Corporation

Distribution Number：BM1857

Articles in press have been peer-reviewed and accepted, which are not yet assigned to volumes /issues, but are citable by Digital Object Identifier (DOI).

查看更多

Expert Forum

The status quo and prospect of "Internet Plus" community empowerment

DAI Hua, DENG Hong-yu, YUAN Bo, WU Jia, ZHAO Qian

2022, 20(2): 175-178. doi: 10.16766/j.cnki.issn.1674-4152.002306

<Abstract> <HTML> <PDF下载>

42 14

2022, 20(2): 179-180.

<Abstract> <HTML> <PDF下载>

19 4

General Practice Research

Risk assessment model of diabetic nephropathy with "same disease and different syndromes" in traditional Chinese medicine based on multi-label machine learning

TONG Xu, YANG Chun, MENG Qing-gang

2022, 20(2): 181-185, 227. doi: 10.16766/j.cnki.issn.1674-4152.002307

<Abstract> <HTML> <PDF下载>

31 1

查看更多

14 2022-01
Notice Test Data One

13 2022-01
News Test Data One

Submission System

Author Peer Review Editorial Entry

ArchiveMore>

2022
2021

1

1
2
3
4
5
6
7
8
9
10
11
12

DownloadMore>

Download Center Test Data One

LinksMore>

Links Test Data One

Email Alert RSS

Address：No. 287 mayor Huai Road, Bengbu, AnhuiphoneNo：0552-3066635； 0552-3051890Email：zhqkyx@163.com

Copyright © Chinese Journal of General Practice皖ICP备2020018345号-2

Supported by: Beijing Renhe Information Technology Co., Ltd.