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同型半胱氨酸临床应用的研究进展

林妮 柯渠青 蒋玲燕 欧兰芝 刘蝶梅 吴玉颜 杜庆锋

林妮, 柯渠青, 蒋玲燕, 欧兰芝, 刘蝶梅, 吴玉颜, 杜庆锋. 同型半胱氨酸临床应用的研究进展[J]. 中华全科医学, 2021, 19(8): 1358-1361. doi: 10.16766/j.cnki.issn.1674-4152.002060
引用本文: 林妮, 柯渠青, 蒋玲燕, 欧兰芝, 刘蝶梅, 吴玉颜, 杜庆锋. 同型半胱氨酸临床应用的研究进展[J]. 中华全科医学, 2021, 19(8): 1358-1361. doi: 10.16766/j.cnki.issn.1674-4152.002060
LIN Ni, KE Qu-qing, JIANG Ling-yan, OU Lan-zhi, LIU Die-mei, WU Yu-yan, DU Qing-feng. The clinical application value of homocysteine[J]. Chinese Journal of General Practice, 2021, 19(8): 1358-1361. doi: 10.16766/j.cnki.issn.1674-4152.002060
Citation: LIN Ni, KE Qu-qing, JIANG Ling-yan, OU Lan-zhi, LIU Die-mei, WU Yu-yan, DU Qing-feng. The clinical application value of homocysteine[J]. Chinese Journal of General Practice, 2021, 19(8): 1358-1361. doi: 10.16766/j.cnki.issn.1674-4152.002060

同型半胱氨酸临床应用的研究进展

doi: 10.16766/j.cnki.issn.1674-4152.002060
基金项目: 

国家重点研发计划子课题 2020YFC2006401

详细信息
    通讯作者:

    杜庆锋,E-mail:nhyyqk@126.com

  • 中图分类号: R446

The clinical application value of homocysteine

  • 摘要: 同型半胱氨酸(homocysteine,Hcy)产生于必需氨基酸甲硫氨酸向半胱氨酸转化的过程,并通过甲基化作用参与脱氧核糖核酸(DNA)代谢。近年来诸多研究表明,血Hcy水平与多种疾病有直接或间接关系,如动脉硬化、心血管疾病、高血压、神经系统疾病、糖尿病、恶性肿瘤、妊娠期疾病、眼部疾病和骨质疏松等。人体血浆中Hcy的正常范围是5~15 μmol/L,>15 μmol/L为高Hcy血症(hyper homocysteine, HHcy)。基因突变,叶酸、维生素B6、B12缺乏导致的营养不良及高甲硫氨酸的饮食模式均是Hcy升高的常见原因。研究证实,亚甲基四氢叶酸还原酶(methylenetetrahydrofolate reductase, MTHFR)C677T基因多态性与血浆Hcy水平升高的易感性相关。而中国人群中MTHFR 677TT基因型表达显著高于其他种族。血清Hcy水平升高的致病机理可能为:促进炎症和血管钙化;脂质过氧化和抗氧化过程受损;刺激活性氧的产生,诱导氧化应激和血管功能障碍;内皮细胞毒性及功能障碍;抑制神经递质释放等。其他致病机制仍有待进一步研究。Hcy水平在预测疾病风险、控制疾病并发症、影响疾病转归中有重要价值。中国人口总体HHcy患病率较高,且地域差异显著。随着年龄增大,患病率也随之升高。Hcy水平监测有利于疾病的早发现、早诊断及严重并发症的早预防。结合最新文献报道,文章探讨Hcy致病机制及其与疾病的关系,为Hcy的临床应用提供参考。

     

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出版历程
  • 收稿日期:  2020-12-21
  • 网络出版日期:  2022-02-16

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