浙江省40~69岁女性的生活方式与绝经相关症状的相关性研究

胡凯灵; 许凌; 丁悦虹; 马麟娟; 应倩; 周坚红; 宁玉梅

doi:10.16766/j.cnki.issn.1674-4152.003335

浙江省40~69岁女性的生活方式与绝经相关症状的相关性研究

doi: 10.16766/j.cnki.issn.1674-4152.003335

胡凯灵^{1, 2},
许凌³,
丁悦虹³,
马麟娟⁴,
应倩⁵,
周坚红⁴,
宁玉梅^3, ,

1.
慈溪市第三人民医院医疗健康集团妇产科，浙江宁波 315324
2.
杭州师范大学医学院临床医学系，浙江杭州 311121
3.
浙江省妇幼和生殖保健中心临床医务部，浙江杭州 310012
4.
浙江大学医学院附属妇产科医院妇三科，浙江杭州 310006
5.
浙江省肿瘤医院肿瘤研究所，浙江杭州 310022

基金项目:

浙江省医药卫生重大科技计划项目 WKJ-ZJ-1921

详细信息

通讯作者:
宁玉梅，E-mail: 1804257959@qq.com

中图分类号: R173.4 R711.51
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- 文章访问数: 193
- HTML全文浏览量: 59
- PDF下载量: 11
- 被引次数: 0
出版历程
- 收稿日期: 2023-04-20
- 网络出版日期: 2024-03-09

Correlation between lifestyle and menopausal syndrome of females aged 40-69 in Zhejiang Province

1.
The Third People's Hospital Health Care Group of Cixi, Zhejiang 315324, China

摘要

摘要: 目的探讨女性生活方式与绝经相关症状的相关性。方法采用多阶段分层整群抽样方法抽取浙江省40~69岁女性7 856名进行问卷调查，有序变量采用Mantel-Haenszel检验，无序变量采用Kruskal-Wallis H检验，联合多因素logistic回归分析对生活方式与绝经相关症状的相关性进行分析，绘制ROC曲线。结果年龄与绝经及绝经相关症状均具有相关性(P＜0.05)。生活方式中被动吸烟、饮酒、饮茶、体育锻炼强度、烫染发频率(P＜0.05)均与绝经相关症状具有相关性。年龄大(OR=1.103，95% CI：1.094~1.112)、绝经(OR=4.011，95% CI：3.573~4.503)、家属吸烟(OR=1.346，95% CI：1.206~1.501)和工作环境被动吸烟(OR=1.432，95% CI：1.175~1.745)均是绝经相关症状的危险因素(P < 0.05)。低强度体育锻炼(OR=0.881，95% CI：0.822~0.944)、低频率烫发(OR=0.823，95% CI：0.774~0.876)均是绝经相关症状的保护因素(P < 0.05)。生活方式相关因素预测绝经相关症状的ROC曲线下面积为0.731。结论浙江省40~69岁女性生活方式与绝经相关症状具有相关性，可以对女性进行生活方式指导以减少或缓解绝经相关症状。
- 绝经相关症状 /
- 绝经 /
- 生活方式
Abstract: Objective To investigate the correlation between lifestyle and menopausal syndrome of females. Methods A multi-stage stratified cluster sampling method was used to randomly select 7 856 females aged 40-69 in Zhejiang Province for a questionnaire survey. Mantel-Haenszel test was used for ordered categorical variables, Kruskal-Wallis H test was used for disordered variables and multiple logistic aggression analysis were used to determine the correlation between lifestyle and menopausal syndrome and drawn ROC curve. Results Age was associated with menopause and menopausal syndrome (P < 0.05). Passive smoking, drinking, tea drinking, physical exercise intensity, frequency of hair perming and dyeing were associated with menopausal syndrome (P < 0.05). Older age (OR=1.103, 95% CI: 1.094-1.112), menopause (OR=4.011, 95% CI: 3.573-4.503), family members smoking (OR=1.346, 95% CI: 1.206-1.501), and passive smoking in the working environment (OR=1.432, 95% CI: 1.175-1.745) were risk factors for menopausal syndrome (P < 0.05). Lower physical activity intensity (OR=0.881, 95% CI: 0.822-0.944) and low frequency of hair perming (OR=0.823, 95% CI: 0.774-0.876) were protective factors for menopausal syndrome (P < 0.05). The area under the ROC curve for lifestyle-related factors predicting menopause-related symptoms was 0.731. Conclusion The lifestyle of females aged 40-69 in Zhejiang Province is correlated with menopausal syndrome. Lifestyle coaching is recommended for females to reduce or relieve menopausal syndrome.
- Menopausal syndrome /
- Menopause /
- Lifestyle

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图 1 生活方式相关因素预测绝经相关症状的ROC曲线

Figure 1. ROC curve of lifestyle related factors on menopausal syndrome

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表 1 浙江省40~69岁女性生活方式与绝经相关症状发生情况

Table 1. Lifestyle and menopausal syndrome of females aged 40-69 in Zhejiang Province

项目	例(%)	总分0~6分(例)	总分7~15分(例)	总分16~30分(例)	总分＞30分(例)	总分≥7分人数占比(%)	统计量	P值
年龄							79.140^a	< 0.001
40~49岁	2 773(39.150)	2 145	503	111	14	22.647
50~59岁	2 942(41.536)	1 779	856	283	24	39.531
60~69岁	1 368(19.314)	693	533	137	5	49.342
吸烟							2.020^b	0.364
否，从不抽烟	7 037(99.351)	4 583	1 883	528	43	34.873
是	35(0.494)	25	7	3	0	28.571
曾经吸，现已戒烟	11(0.155)	9	2	0	0	18.182
家属吸烟							43.715^b	< 0.001
否	4 318(60.963)	2 942	1 068	283	25	31.867
是	2 765(39.037)	1 675	1 724	248	18	39.421
工作环境被动吸烟							14.650^b	< 0.001
否	6 539(92.320)	4 301	1 724	482	32	34.225
是	544(7.680)	316	168	49	11	41.912
饮酒							9.858^b	0.007
否，从不饮酒	6 529(92.178)	4 277	1 748	465	39	34.492
是	482(6.805)	303	119	57	3	37.137
曾经是，现已戒酒	72(1.017)	37	25	9	1	48.611
饮茶							6.102^b	0.047
否，从不饮	5 640(79.627)	3 696	1 509	406	29	34.468
是，目前仍经常饮	277(3.911)	163	85	23	6	41.155
曾经是，现不经常饮	1 166(16.462)	758	298	102	8	34.991
体育锻炼强度							16.585^a	＜0.001
高强度(如游泳、打球等有氧运动)	200(2.824)	118	56	25	1	41.000
中等强度(如跳舞、慢跑等)	1 289(18.199)	817	342	124	6	36.618
低强度(如步行上班、散步等)	3 427(48.383)	2 213	952	241	21	35.425
几乎不	2 167(30.594)	1 469	542	141	15	32.210
烫发频率							11.400^a	0.010
≥3次/年	208(2.937)	128	65	14	1	38.462
1~2次/年	1 352(19.088)	817	395	130	10	39.571
< 1次/年	2 038(28.773)	1 357	526	141	14	33.415
从不	3 485(49.202)	2 315	906	246	18	33.572
染发频率							24.128^a	< 0.001
≥3次/年	703(9.925)	418	200	79	6	40.541
1~2次/年	1 728(24.396)	1 061	510	146	11	38.600
< 1次/年	1 804(25.469)	1 255	411	129	9	30.432
从不	2 848(40.209)	1 883	771	177	17	33.883
绝经							424.644^b	< 0.001
未绝经	3 261(46.040)	2 530	602	119	10	22.416
绝经	3 822(53.960)	2 087	1 290	412	33	45.395
注：^a为χ²值，^b为Z值。

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表 2 浙江省40~69岁女性绝经相关症状影响因素多因素logistic回归分析

Table 2. Multiple logistic aggression analysison of influencing factors to menopausal syndrome in females aged 40-69 in Zhejiang province

变量	B	SE	Waldχ²	P值	OR值	95% CI
家属吸烟	0.297	0.056	28.369	< 0.001	1.346	1.206~1.501
工作环境被动吸烟	0.359	0.101	12.640	< 0.001	1.432	1.175~1.745
体育锻炼强度	-0.127	0.035	12.828	< 0.001	0.881	0.822~0.944
烫发频率	-0.194	0.032	37.431	< 0.001	0.823	0.774~0.876
是否绝经	1.389	0.059	553.341	< 0.001	4.011	3.573~4.503
年龄	0.098	0.004	564.737	< 0.001	1.103	1.094~1.112
注：因变量及其赋值，KMI＜7分为=0，KMI≥7分=1；自变量及其赋值，家属吸烟为否=0，是=1；工作环境被动吸烟为否=0，是=1；体育锻炼强度为高强度=0，中强度=1，低强度=2，几乎不锻炼=3；烫发频率≥3次/年=0，1~2次/年=1，＜1次/年=2，从不=3；未绝经=0，绝经=1；年龄为40~49岁=0，50~59岁=1，60~69岁=2。

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参考文献(23)

[1]	LYU J C, ZHANG W, LI W, et al. Epidemic of chronic diseases and the related healthy lifestyle interventions in rural areas of Shandong province, China[J]. BMC Public Health, 2020, 20(1): 606. doi: 10.1186/s12889-020-08729-y
[2]	GALLAGHER P, BOLAND C, MCCLENAGHAN A, et al. Improved self-esteem and activity levels following a 12-week community activity and healthy lifestyle programme in those with serious mental illness: a feasibility study[J]. Early Interv Psychiatry, 2021, 15(2): 367-373. doi: 10.1111/eip.12965
[3]	杜学礼, 汪颖霞, 金晟, 等. 基于CiteSpace的生活方式与健康关系文献计量学研究[J]. 中国健康教育, 2021, 37(10): 920-924, 929. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGJK202110013.htm DU X L, WANG Y X, JIN S, et al. The bibliometric study on the relationship between lifestyle and health based on CiteSpace visualization[J]. Chinese Journal of Health Education, 2021, 37(10): 920-924, 929. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGJK202110013.htm
[4]	LIU X L, FU X, DU R, et al. Epidemiology and risk factors of menopause syndrome among uyghur, Han, and Kazak Women in Xinjiang, China[J]. Med Sci Monit, 2018, 24: 8950-8958. doi: 10.12659/MSM.909954
[5]	DAVID P S, KLING J M, VEGUNTA S, et al. Vasomotor symptoms in women over 60: results from the data registry on experiences of aging, menopause, and sexuality (dreams)[J]. Menopause, 2018, 25(10): 1105-1109. doi: 10.1097/GME.0000000000001126
[6]	SUN X Y, ZHANG R, WANG L R, et al. Association between parity and the age at menopause and menopausal syndrome in northwest China[J]. Asia Pac J Public Health, 2021, 33(1): 60-66. doi: 10.1177/1010539520960987
[7]	PRIYA K, SETTY M, BABU U V, et al. Implications of environmental toxicants on ovarian follicles: how it can adversely affect the female fertility?[J]. Environ Sci Pollut Res Int, 2021, 28(48): 67925-67939. doi: 10.1007/s11356-021-16489-4
[8]	ERDEM GUZEL E, KAYA N, TEKTEMUR A, et al. Chronic effects of maternal tobacco-smoke exposure and/or α-lipoic acid treatment on reproductive parameters in female rat offspring[J]. Syst Biol Reprod Med, 2020, 66(6): 387-399. doi: 10.1080/19396368.2020.1815248
[9]	ZAHREDDINE R, DAVEZAC M, BUSCATO M, et al. A historical view of estrogen effect on arterial endothelial healing: from animal models to medical implication[J]. Atherosclerosis, 2021, 338: 30-38. doi: 10.1016/j.atherosclerosis.2021.10.013
[10]	DE ANGELIS C, NARDONE A, GARIFALOS F, et al. Smoke, alcohol and drug addiction and female fertility[J]. Reprod Biol Endocrinol, 2020, 18(1): 21. doi: 10.1186/s12958-020-0567-7
[11]	康菁, 王青青, 瞿俊樯, 等. 上海市徐汇区某社区绝经女性骨质疏松患者现况调查与需求分析[J]. 中华全科医学, 2018, 16(10): 1686-1689. doi: 10.16766/j.cnki.issn.1674-4152.000460 KANG J, WANG Q Q, QU J Q, et al. Status survey and demand analysis on osteoporosis of postmenopausal women in a certain community of Xuhui district of Shanghai[J]. Chinese Journal of General Practice, 2018, 16(10): 1686-1689. doi: 10.16766/j.cnki.issn.1674-4152.000460
[12]	随璐, 孙巧霞, 王云. 生活方式和环境因素对育龄期妇女卵巢储备功能的影响[J]. 中国医药指南, 2019, 17(28): 10-11. https://www.cnki.com.cn/Article/CJFDTOTAL-YYXK201928007.htm SUI L, SUN Q X, WANG Y. The Effect of Lifestyle and Environmental Factors on Ovarian Reserve Function of Fertile Women[J]. Guide of China Medicine, 2019, 17(28): 10-11. https://www.cnki.com.cn/Article/CJFDTOTAL-YYXK201928007.htm
[13]	TIN TIN S, KEY T J, REEVES G K. Alcohol intake and endogenous hormones in pre-and postmenopausal women: findings from the UK biobank[J]. Cancer Epidemiol Biomarkers Prev, 2021, 30(12): 2294-2301. doi: 10.1158/1055-9965.EPI-21-0789
[14]	FREEMAN J R, WHITCOMB B W, PURDUE-SMITHE A C, et al. Is alcohol consumption associated with risk of early menopause?[J]. Am J Epidemiol, 2021, 190(12): 2612-2617. doi: 10.1093/aje/kwab182
[15]	BALÁŽI A, SIROTKIN A V, FÖLDE${\rm{\bar S}}$IOVÁ M, et al. Green tea can supress rabbit ovarian functions in vitro and in vivo[J]. Theriogenology, 2019, 127: 72-79. doi: 10.1016/j.theriogenology.2019.01.010
[16]	BARROS M P, BACHI A L L, SANTOS J M B D, et al. The poorly conducted orchestra of steroid hormones, oxidative stress and inflammation in frailty needs a maestro: regular physical exercise[J]. Exp Gerontol, 2021, 155: 111562. DOI: 10.1016/j.exger.2021.111562.
[17]	杜远, 王龙, 张许来, 等. 运动对抑郁症症状、认知功能和γ-氨基丁酸影响的对照研究[J]. 中华全科医学, 2019, 17(9): 1547-1550. doi: 10.16766/j.cnki.issn.1674-4152.000994 DU Y, WANG L, ZHANG X L, et al. Control study of exercise' influence on depression' s symptom, cognitive function and GABA[J]. Chinese Journal of General Practice, 2019, 17(9): 1547-1550. doi: 10.16766/j.cnki.issn.1674-4152.000994
[18]	KASHETSKY N, LAW R M, WOLFRAM L J, et al. Hair dyes: a systematic review of pertinent in vivo human studies[J]. Arch Dermatol Res, 2021, 313(7): 509-516. doi: 10.1007/s00403-020-02157-z
[19]	ZHANG Y, BIRMANN B M, HAN J L, et al. Personal use of permanent hair dyes and cancer risk and mortality in US women: prospective cohort study[J]. BMJ, 2020, 370: m2942. DOI: 10.1136/bmj.m2942.
[20]	何冬梅, 周开霞, 简润姿, 等. 染发与卵巢早衰相关性的Meta分析[J]. 中国妇幼卫生杂志, 2019, 10(3): 20-24. https://www.cnki.com.cn/Article/CJFDTOTAL-YZWS201903005.htm HE D M, ZHOU K X, JIAN R Z, et al. Meta analysis of correlation between dyeing hair and premature ovarian failure[J]. Chinese Journal of Women and Children Health, 2019, 10(3): 20-24. https://www.cnki.com.cn/Article/CJFDTOTAL-YZWS201903005.htm
[21]	WHITE A J, SANDLER D P, GASTON S A, et al. Use of hair products in relation to ovarian cancer risk[J]. Carcinogenesis, 2021, 42(9): 1189-1195. doi: 10.1093/carcin/bgab056
[22]	EVANS T. A review of permanent waving and perm chemistry[J]. J Cosmet Sci, 2021, 72(1): 99-133.
[23]	李淑平, 熊正爱, 王智亮, 等. 临床综合干预对围绝经期女性健康及生活质量改善的研究[J]. 现代医药卫生, 2019, 35(1): 85-87. doi: 10.3969/j.issn.1009-5519.2019.01.024 LI S P, XIONG Z A, WANG Z L, et al. Study on the improvement of health and quality of life of perimenopausal women by clinical comprehensive intervention[J]. Mod Med Health, 2019, 35(1): 85-87. doi: 10.3969/j.issn.1009-5519.2019.01.024