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妊娠晚期血清维生素D及血管内皮生长因子与子痫前期及胎儿生长受限的相关性分析

钟双飞 沈娜 黄满仙

钟双飞, 沈娜, 黄满仙. 妊娠晚期血清维生素D及血管内皮生长因子与子痫前期及胎儿生长受限的相关性分析[J]. 中华全科医学, 2024, 22(1): 82-85. doi: 10.16766/j.cnki.issn.1674-4152.003336
引用本文: 钟双飞, 沈娜, 黄满仙. 妊娠晚期血清维生素D及血管内皮生长因子与子痫前期及胎儿生长受限的相关性分析[J]. 中华全科医学, 2024, 22(1): 82-85. doi: 10.16766/j.cnki.issn.1674-4152.003336
ZHONG Shuangfei, SHEN Na, HUANG Manxian. Correlation between serum vitamins and vascular endothelial growth factor in late pregnancy and pre-eclampsia and fetal growth restriction[J]. Chinese Journal of General Practice, 2024, 22(1): 82-85. doi: 10.16766/j.cnki.issn.1674-4152.003336
Citation: ZHONG Shuangfei, SHEN Na, HUANG Manxian. Correlation between serum vitamins and vascular endothelial growth factor in late pregnancy and pre-eclampsia and fetal growth restriction[J]. Chinese Journal of General Practice, 2024, 22(1): 82-85. doi: 10.16766/j.cnki.issn.1674-4152.003336

妊娠晚期血清维生素D及血管内皮生长因子与子痫前期及胎儿生长受限的相关性分析

doi: 10.16766/j.cnki.issn.1674-4152.003336
基金项目: 

浙江省医药卫生科技计划面上项目 2021KY383

详细信息
    通讯作者:

    沈娜,E-mail:lhst008@163.com

  • 中图分类号: R714.246

Correlation between serum vitamins and vascular endothelial growth factor in late pregnancy and pre-eclampsia and fetal growth restriction

  • 摘要:   目的  探讨妊娠晚期血清维生素D及血管内皮生长因子(VEGF)与子痫前期及胎儿生长受限(FGR)的相关性,以期为诊治子痫前期和FGR提供依据。  方法  选择舟山市妇幼保健院2020年7月—2022年12月收治的妊娠晚期子痫前期孕妇124例为研究组,其中伴FGR 38例;另选择同期妊娠晚期正常孕妇54例为对照组。采用电化学免疫分析法测定2组孕妇血清25-羟维生素-D(25-OH-D)水平,酶联免疫吸附法测定血清VEGF水平。  结果  研究组血清25-OH-D[(73.42±6.71)nmol/L]和VEGF[(412.31±35.24)pg/mL]均低于对照组[(94.78±5.25)nmol/L、(536.21±26.23)pg/mL,P<0.05]。FGR组血清25-OH-D[(69.20±5.96)nmol/L]和VEGF[(394.70±32.17)pg/mL]均低于无FGR组[(82.97±7.28)nmol/L、(452.17±27.49)pg/mL,P<0.05]。25-OH-D和VEGF与子痫前期和FGR均呈负相关关系(P<0.05)。25-OH-D预测子痫前期和FGR的灵敏度为83.30%和76.29%,特异度为77.43%和64.19%;VEGF预测子痫前期和FGR的灵敏度为80.13%和68.08%,特异度为68.92%和56.24%。25-OH-D和VEGF为子痫前期和FGR的独立影响因素。  结论  妊娠晚期子痫前期及FGR患者血清25-OH-D和VEGF水平下降,且与子痫前期及FGR的发生呈负相关关系。

     

  • 图  1  ROC曲线分析25-OH-D和VEGF对子痫前期的预测价值

    Figure  1.  ROC curve analysis of the predictive value of 25-OH-D and VEGF for preeclampsia

    图  2  25-OH-D和VEGF对FGR预测价值的ROC曲线

    Figure  2.  ROC curve analysis of the predictive value of 25-OH-D and VEGF for FGR

    表  1  研究组与对照组孕妇血清25-OH-D和VEGF水平比较(x±s)

    Table  1.   Comparison of serum 25-OH-D and VEGF levels between the study group and the control group(x±s)

    组别 例数 25-OH-D(nmol/L) VEGF(pg/mL)
    研究组 124 73.42±6.71 412.31±35.24
    对照组 54 94.78±5.25 536.21±26.23
    t 20.775 23.177
    P <0.001 <0.001
    下载: 导出CSV

    表  2  FGR组与无FGR组子痫前期孕妇血清25-OH-D和VEGF水平比较(x±s)

    Table  2.   Comparison of serum 25-OH-D and VEGF levels between the pre eclampsia FGR group and the non FGR group(x±s)

    组别 例数 25-OH-D(nmol/L) VEGF(pg/mL)
    FGR组 38 69.20±5.96 394.70±32.17
    无FGR组 86 82.97±7.28 452.17±27.49
    t 11.236 10.177
    P <0.001 <0.001
    下载: 导出CSV

    表  3  25-OH-D和VEGF与子痫前期和FGR的相关性分析

    Table  3.   Correlation analysis of 25-OH-D and VEGF with preeclampsia and FGR

    项目 子痫前期 FGR
    r P r P
    25-OH-D -0.762 < 0.001 -0.624 < 0.001
    VEGF -0.698 < 0.001 -0.516 < 0.001
    下载: 导出CSV

    表  4  25-OH-D和VEGF对子痫前期的预测价值分析

    Table  4.   ROC curve analysis of the predictive value of 25-OH-D and VEGF for preeclampsia

    项目 AUC 95% CI 截断值 P 灵敏度(%) 特异度(%)
    25-OH-D 0.880 0.830~0.931 80.60 nmol/L <0.001 83.30 77.43
    VEGF 0.842 0.779~0.906 475.22 pg/mL <0.001 80.13 68.92
    25-OH-D联合VEGF 0.939 0.903~0.974 <0.001 94.53ab 89.91ab
    注:与25-OH-D比较,χ2值分别为3.982、4.864,aP<0.05;与VEGF比较,χ2值分别为4.659、7.965,bP<0.05。
    下载: 导出CSV

    表  5  25-OH-D和VEGF对FGR的预测价值分析

    Table  5.   ROC curve analysis of the predictive value of 25-OH-D and VEGF for FGR

    项目 AUC 95% CI 截断值 P 灵敏度(%) 特异度(%)
    25-OH-D 0.754 0.654~0.853 73.85 nmol/L <0.001 76.29 64.19
    VEGF 0.665 0.562~0.768 416.50 pg/mL 0.004 68.08 56.24
    25-OH-D联合VEGF 0.859 0.782~0.935 <0.001 84.90ab 86.80ab
    注:与25-OH-D比较,χ2值分别为4.413、7.476,aP<0.05;与VEGF比较,χ2值分别为5.871、9.628,bP<0.05。
    下载: 导出CSV

    表  6  25-OH-D和VEGF与子痫前期关系的多因素logistic回归分析

    Table  6.   Multivariate logistic regression analysis of the relationship between 25-OH-D, VEGF and preeclampsia

    变量 B SE Waldχ2 P OR 95% CI
    25-OH-D 1.498 0.517 8.395 0.004 4.473 1.624~12.321
    VEGF 1.561 0.627 6.198 0.013 4.764 1.394~16.280
    下载: 导出CSV

    表  7  25-OH-D和VEGF与FGR关系的多因素logistic回归分析

    Table  7.   Multivariate logistic regression analysis of the relationship between 25-OH-D, VEGF and FGRs

    变量 B SE Waldχ2 P OR 95% CI
    25-OH-D 1.637 0.625 6.860 0.009 5.140 1.510~17.496
    VEGF 1.546 0.621 6.198 0.013 4.693 1.389~15.850
    下载: 导出CSV
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  • 收稿日期:  2023-03-30
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