Research hotspot and development trend of cellular burial in atherosclerosis analyzed based on Web of Science
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摘要:
目的 通过对动脉粥样硬化(AS)胞葬相关英文文献进行计量及可视化分析，探索该领域研究现状、热点及动态前沿。 方法 以Web of Science数据库中的核心合集为数据源，对建库至2022年12月1日收录的AS胞葬相关文献进行可视化法分析，借助VOSviewer对国家/地区、机构、期刊、作者分布进行分析，借助CiteSpace 6.1.R4软件绘制关键词可视化图谱。 结果 纳入258篇SCI文章，发文量呈逐年增加趋势。高产作者TABAS I A发文数量及被引次数均最多，高产国家包括美国、中国、德国等。收录AS胞葬相关SCI文献质量均较高(JCR分区Q1、Q2)，其中《Arteriosclerosis Thrombosis And Vascular Biology》杂志收录最多。“apoptotic cell”“activation”“expression”是重要的关键词，“macrophage”“NLRP3 inflammasome”“inflammation resolution”等是近3年的突变词。 结论 本领域研究热点包括凋亡细胞、炎症、激活、巨噬细胞、吞噬作用等，预测未来将围绕AS胞葬的机制、巨噬细胞、AS的治疗策略继续深入研究。 -
关键词:
- 动脉粥样硬化 /
- 胞葬 /
- CiteSpace /
- Web of Science /
- 可视化分析
Abstract:Objective To explore the current status, hot spots and dynamic frontiers of research in the field of atherosclerosis (AS) through metric and visualization analysis of the English literature related to AS efferocytosis. Methods Using the core collection in Web of Science database as the data source, we analyzed the literature related to AS efferocytosis from the year of library construction to December 1, 2022 by visualization method, analyzed the distribution of countries/regions, institutions, journals and authors with the help of VOSviewer, and drew the keyword visualization map with the help of CiteSpace 6.1.R4 software. Results A total of 258 SCI articles were included, and the number of publications showed an increasing trend year by year. High-producing authors Tabas, I A. had the highest number of articles and citations, and the high-producing countries included the United States, China, and Germany, etc. The quality of SCI literature related to AS efferocytosis were high (JCR partition Q1 and Q2), among which the journal "Arteriosclerosis Thrombosis And Vascular Biology" contained the most. "Apoptotic cell", "activation", "expression" were important keywords. "Macrophage", "NLRP3 inflammasome" and "inflammation resolution" were the mutation words in the last three years. Conclusion The hotspots of research in this field include apoptotic cells, inflammation, activation, macrophages, phagocytosis, etc. It is predicted that the mechanism of AS efferocytosis, macrophages, and AS treatment strategies will continue to be studied in depth in the future. -
Key words:
- Atherosclerosis /
- Efferocytosis /
- CiteSpace /
- Web of Science /
- Visualization analysis
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表 1 不同年份发文量
Table 1. Annual issuance of articles
年份 发文量(篇) 年份 发文量(篇) 2007 2 2015 11 2008 1 2016 14 2009 4 2017 23 2010 5 2018 19 2011 5 2019 22 2012 13 2020 27 2013 12 2021 31 2014 10 2022 36 
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表 2 作者发文量及被引情况
Table 2. Author publications and citations
作者 发文量(篇) 被引频次(次) TABAS I A 33 3 722 NICHOLAS J L 11 589 ARIF YURDAGUL J 10 1 163 MANIKANDAN S 10 976 GABRIELLE F 9 622 KOJIMA Y 9 561 LINTON M F 9 531 CAI B S 8 684 FISHER E A 8 477 SAHEBKAR A 8 189
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表 3 国家发文量及被引情况
Table 3. Number of national publications and citations
国家 发文量(篇) 被引频次(次) USA(美国) 128 7 288 CHINA(中国) 53 992 GERMANY(德国) 25 1 487 CANADA(加拿大) 17 496 SWEDEN(瑞典) 16 1 297 ENGLAND(英格兰) 15 676 NETHERLANDS(荷兰) 14 789 ITALY(意大利) 12 368 FRANCE(法国) 11 366 JAPAN(日本) 10 386
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表 4 期刊发文量情况(发文量>5篇)
Table 4. Volume of journal articles (number of articles>5)
期刊名称 发文量
(篇)被引频次
(次)IF JCR分区 Arteriosclerosis Thrombosis And Vascular Biology 29 1 318 10.514 Q1 Circulation Research 14 1 038 23.213 Q1 Circulation 12 386 39.918 Q1 Atherosclerosis 9 49 6.847 Q1 Frontiers in Cardiovascular Medicine 7 225 5.846 Q2 Frontiers in Immunology 6 152 8.786 Q1 Journal of Clinical Investigation 5 385 19.456 Q1 Frontiers in Pharmacology 5 120 5.988 Q1 Cardiovascular Research 5 125 13.081 Q1
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表 5 聚类标签
Table 5. Clustering labels
聚类编号 聚类大小 聚类轮廓 聚类关键词 0 50 0.675 unfolded protein response；er stress；beta 5i；coronary events 1 47 0.695 macrophage survival；calcium channels；calcium influx；vulnerable plaque；mechanism 2 46 0.639 resolution；annexin a5；phosphatidylserine；macrophages；phagocytosis 3 39 0.684 nitric oxide synthase；coronary heart disease；necrotic core；vascular biology；oxidative stress 4 34 0.659 metabolism；lxr；inhibition；containing monooxygenase 3；thromboxane 5 32 0.773 scavenger receptor；atp-binding cassette transporters；pinocytosis；apoptotic cell；cholesterol efflux 6 30 0.621 lipids；low density lipoprotein；advanced atherosclerotic lesion；human immunodeficiency virus；atherogenic lipoprotein 7 27 0.746 accumulation；leukocytes；nf kappa b；foam cells；telomere 8 14 0.906 macrophage polarization；efflux；bone marrow；density lipoprotein；sr-b1
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[1] 中华医学会老年医学分会老年神经病学组, 北京神经科学学会血管神经病学专业委员会, 动脉粥样硬化性缺血性卒中/短暂性脑缺血发作合并冠心病诊治中国专家共识编写组. 动脉粥样硬化性缺血性卒中/短暂性脑缺血发作合并冠心病诊治中国专家共识(2022)[J]. 中华医学杂志, 2022, 102(45): 3569-3580.Geriatric Neurology Group of Geriatrics Branch of Chinese Medical Association, Vascular Neurology Committee of Beijing Neuroscience Society, Atherosclerotic Ischemic Stroke in Combination with Transient Ischemic Attack and Coronary Artery Disease Chinese Expert Consensus Writing Group. Chinese expert consensus on the diagnosis and management of atherosclerotic ischemic stroke/transient ischemic attack combined with coronary artery disease (2022)[J]. Chinese Journal of Medicine, 2022, 102(45): 3569-3580. [2] 汤紫薇, 谷依檬, 薛梅. 基于免疫炎症学说中医药防治动脉粥样硬化研究[J]. 中国中医基础医学杂志, 2022, 28(7): 1192-1198. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYJC202207043.htmTANG Z W, GU Y M, XUE M. Research on the prevention and treatment of atherosclerosis in Chinese medicine based on the immunoinflammatory theory[J]. Chinese Journal of Basic Chinese Medicine, 2022, 28(7): 1192-1198. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYJC202207043.htm [3] ZHANG W, ZHAO J, WANG R, et al. Macrophages reprogram after ischemic stroke and promote efferocytosis and inflammation resolution in the mouse brain[J]. CNS Neurosci Ther, 2019, 25(12): 1329-1342. doi: 10.1111/cns.13256 [4] ARANDJELOVIC S, RAVICHANDRAN K S. Phagocytosis of apoptotic cells in homeostasis[J]. Nat Immunol, 2015, 16(9): 907-917. doi: 10.1038/ni.3253 [5] TABAS I, GARCÍA-CARDEÑA G, OWENS G K. Recent insights into the cellular biology of atherosclerosis[J]. J Cell Biol, 2015, 209(1): 13-22. doi: 10.1083/jcb.201412052 [6] KOJIMA Y, VOLKMER J P, MCKENNA K, et al. CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis[J]. Nature, 2016, 536(7614): 86-90. doi: 10.1038/nature18935 [7] THORP E B. Mechanisms of failed apoptotic cell clearance by phagocyte subsets in cardiovascular disease[J]. Apoptosis, 2010, 15(9): 1124-1136. doi: 10.1007/s10495-010-0516-6 [8] 陈悦, 刘则渊. 悄然兴起的科学知识图谱[J]. 科学学研究, 2005, 23(2): 149-154. https://www.cnki.com.cn/Article/CJFDTOTAL-KXYJ200502001.htmCHEN Y, LIU Z Y. The quiet emergence of scientific knowledge mapping[J]. Scientific Research, 2005, 23(2): 149-154. https://www.cnki.com.cn/Article/CJFDTOTAL-KXYJ200502001.htm [9] 陈悦, 陈超美, 胡志刚. 引文空间分析原理与应用: CiteSpace实用指南[M]. 北京: 科学出版社, 2014: 10-20.CHEN Y, CHEN C M, LIU Z Y, et al. Principles and applications of citation space analysis CiteSpace practical guide[M]. Beijing: Science Press, 2014: 10-20. [10] AI Y, XING Y, YAN L, et al. Atrial fibrillation and depression: a bibliometric analysis from 2001 to 2021[J]. Front Cardiovasc Med, 2022, 9: 775329. DOI: 10.3389/fcvm.2022.775329. [11] 陈悦, 陈超美, 刘则渊, 等. CiteSpace知识图谱的方法论功能[J]. 科学学研究, 2015, 33(2): 242-253. https://www.cnki.com.cn/Article/CJFDTOTAL-KXYJ201502009.htmCHEN Y, CHEN C M, LIU Z Y, et al. Methodological functions of CiteSpace knowledge graphs[J]. Scientology Research, 2015, 33(2): 242-253. https://www.cnki.com.cn/Article/CJFDTOTAL-KXYJ201502009.htm [12] NICHOLLS S J, PURI R, ANDERSON T, et al. Effect of Evolocumab on progression of coronary disease in statin-treated patients: the GLAGOV randomized clinical trial[J]. JAMA, 2016, 316(22): 2373-2384. doi: 10.1001/jama.2016.16951 [13] KOJIMA Y, WEISSMAN I L, LEEPER N J. The role of efferocytosis in atherosclerosis[J]. Circulation, 2017, 135(5): 476-489. doi: 10.1161/CIRCULATIONAHA.116.025684 [14] 王烁珊, 吴敬国, 荆小莉, 等. 甘油三酯葡萄糖指数与冠状动脉粥样硬化性心脏病关系的研究进展[J]. 中华全科医学, 2021, 19(6): 1008-1012. doi: 10.16766/j.cnki.issn.1674-4152.001972WANG S S, WU J G, JING X L, et al. Research progress on the relationship between triglyceride glucose index and coronary atherosclerotic heart disease[J]. Chinese Journal of General Practice, 2021, 19(6): 1008-1012. doi: 10.16766/j.cnki.issn.1674-4152.001972 [15] 杨晓明, 王审. 长期大剂量服用阿托伐他汀对老年高血压合并冠心病的疗效和安全性评价[J]. 中华全科医学, 2018, 16(12): 2035-2038. doi: 10.16766/j.cnki.issn.1674-4152.000555YANG X M, WANG S. . Evaluation of the efficacy and safety of long-term high-dose administration of atorvastatin in elderly with hypertension combined with coronary heart disease[J]. Chinese Journal of General Practice, 2018, 16(12): 2035-2038. doi: 10.16766/j.cnki.issn.1674-4152.000555 [16] TAJBAKHSH A, BIANCONI V, PIRRO M, et al. Efferocytosis and atherosclerosis: regulation of phagocyte function by microRNAs[J]. Trends Endocrinol Metab, 2019, 30(9): 672-683. doi: 10.1016/j.tem.2019.07.006 [17] DORAN A C, YURDAGUL A J, TABAS I. Efferocytosis in health and disease[J]. Nat Rev Immunol, 2020, 20(4): 254-267. doi: 10.1038/s41577-019-0240-6 [18] LUMBROSO D, SOBOH S, MAIMON A, et al. Macrophage-derived protein S facilitates apoptotic polymorphonuclear cell clearance by resolution phase macrophages and supports their reprogramming[J]. Front Immunol, 2018, 9: 358. doi: 10.3389/fimmu.2018.00358 [19] CAI B, KASIKARA C, DORAN A C, et al. MerTK signaling in macrophages promotes the synthesis of inflammation resolution mediators by suppressing CaMKII activity[J]. Sci Signal, 2018, 11(549): eaar3721. DOI: 10.1126/scisignal.aar3721. [20] YURDAGUL A J, DORAN A C, CAI B, et al. Mechanisms and consequences of defective efferocytosis in atherosclerosis[J]. Front Cardiovasc Med, 2018, 4: 86. doi: 10.3389/fcvm.2017.00086 [21] BOTEANU R M, SUICA V I, UYY E, et al. Alarmins in chronic noncommunicable diseases: atherosclerosis, diabetes and cancer[J]. J Proteomics, 2017, 153: 21-29. doi: 10.1016/j.jprot.2016.11.006 [22] CHAZAUD B. Inflammation and skeletal muscle regeneration: leave it to the macrophages![J]. Trends Immunol, 2020, 41(6): 481-492. doi: 10.1016/j.it.2020.04.006 [23] REN J, BI Y, SOWERS J R, et al. Endoplasmic reticulum stress and unfolded protein response in cardiovascular diseases[J]. Nat Rev Cardiol, 2021, 18(7): 499-521. [24] LIN P, JI H H, LI Y J, et al. Macrophage Plasticity and Atherosclerosis Therapy[J]. Front Mol Biosci, 2021, 8: 679797. DOI: 10.3389/fmolb.2021.679797. [25] KOJIMA Y, DOWNING K, KUNDU R, et al. Cyclin-dependent kinase inhibitor 2B regulates efferocytosis and atherosclerosis[J]. J Clin Invest, 2019, 129(5): 2164. doi: 10.1172/JCI129277 [26] MOORE K J, TABAS I. Macrophages in the pathogenesis of atherosclerosis[J]. Cell, 2011, 145(3): 341-355. doi: 10.1016/j.cell.2011.04.005 [27] MARTINET W, SCHRIJVERS D M, DE MEYER G R. Necrotic cell death in atherosclerosis[J]. Basic Res Cardiol, 2011, 106(5): 749-760. doi: 10.1007/s00395-011-0192-x [28] JIN Y, LIU Y, XU L, et al. Novel role for caspase 1 inhibitor VX765 in suppressing NLRP3 inflammasome assembly and atherosclerosis via promoting mitophagy and efferocytosis[J]. Cell Death Dis, 2022, 13(5): 512. doi: 10.1038/s41419-022-04966-8 [29] MARTINET W, COORNAERT I, PUYLAERT P, et al. Macrophage death as a pharmacological target in atherosclerosis[J]. Front Pharmacol, 2019, 10: 306. doi: 10.3389/fphar.2019.00306 [30] RAYMOND M H, DAVIDSON A J, SHEN Y, et al. Live cell tracking of macrophage efferocytosis during Drosophila embryo development in vivo[J]. Science, 2022, 375(6585): 1182-1187. doi: 10.1126/science.abl4430 -
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