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成人普通变异型免疫缺陷病1例报道并文献复习

钟海媚 凌华湘 黄立霞 王红燕

钟海媚, 凌华湘, 黄立霞, 王红燕. 成人普通变异型免疫缺陷病1例报道并文献复习[J]. 中华全科医学, 2024, 22(1): 172-174. doi: 10.16766/j.cnki.issn.1674-4152.003357
引用本文: 钟海媚, 凌华湘, 黄立霞, 王红燕. 成人普通变异型免疫缺陷病1例报道并文献复习[J]. 中华全科医学, 2024, 22(1): 172-174. doi: 10.16766/j.cnki.issn.1674-4152.003357
ZHONG Haimei, LING Huaxiang, HUANG Lixia, WANG Hongyan. Adult common variable immunodeficiency: a case report and literature review[J]. Chinese Journal of General Practice, 2024, 22(1): 172-174. doi: 10.16766/j.cnki.issn.1674-4152.003357
Citation: ZHONG Haimei, LING Huaxiang, HUANG Lixia, WANG Hongyan. Adult common variable immunodeficiency: a case report and literature review[J]. Chinese Journal of General Practice, 2024, 22(1): 172-174. doi: 10.16766/j.cnki.issn.1674-4152.003357

成人普通变异型免疫缺陷病1例报道并文献复习

doi: 10.16766/j.cnki.issn.1674-4152.003357
基金项目: 

广东省医学科学技术研究基金项目 A2022497

详细信息
    通讯作者:

    王红燕,E-mail: doctorwanghongyan@163.com

  • 中图分类号: R593.3

Adult common variable immunodeficiency: a case report and literature review

  • 摘要: 本文报道1例成人普通变异型免疫缺陷病(CVID),患者男性, 38岁,发病前身体素质良好,10年前开始因反复发生肺部及其他部位感染多次住院,此次因“肺部感染”再次入院,入院查免疫球蛋白普遍低下,排除其他引起免疫球蛋白低下的可能原因后考虑诊断CVID,予积极静脉补充免疫球蛋白、抗感染等治疗后症状缓解,但予静脉输入丙种球蛋白后复查免疫球蛋白并无明显提高,建议患者出院后长期规律补充丙种球蛋白后复查。

     

  • 图  1  支气管镜下活检肺组织病理(HE染色,×80)

    Figure  1.  Pathology section of lung tissue form the bronchoscopic biopsy (HE staining, ×80)

    表  1  患者外周血及肺泡灌洗液淋巴细胞亚群比值

    Table  1.   Lymphocyte subsets ratio in peripheral blood and alveolar lavage fluid

    项目名称 检测结果 参考范围
    外周血
      CD3+(%) 89.70 61.00~85.00
      CD3+CD4+(%) 19.00 28.00~58.00
      CD3+CD8+(%) 65.60 19.00~48.00
      CD4+/CD8+比值 0.29 0.90~3.60
      CD3-CD19+(%) 7.80 9.00~14.00
      CD3-CD56+(%) 0.80 10.00~19.80
      CD3-CD56+CD16+(%) 7.40 0~2.00
    肺泡灌洗液
      CD3+(%) 89.80 70.00[2]
      CD3+CD4+(%) 58.10 50.00[2]
      CD3+CD8+(%) 29.80 30.00[2]
      CD4+/CD8+比值 1.95 1.50~1.80[2]
    注:肺泡灌洗液参考范围参照文献[2]。
    下载: 导出CSV

    表  2  患者的免疫球蛋白水平

    Table  2.   The patient's immunoglobulin levels

    血清总免疫球蛋白 治疗前 输注丙种球蛋白2.5 g/d,6 d后 参考范围
    IgM(g/L) 0.86 0.18 0.40~2.30
    IgA(g/L) 0.27 0.27 0.70~4.00
    IgG(g/L) 1.46 1.77 7.00~16.00
    C3(g/L) 0.86 1.00 0.90~1.80
    C4(g/L) 0.23 0.26 0.10~0.40
    下载: 导出CSV
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出版历程
  • 收稿日期:  2023-05-11
  • 网络出版日期:  2024-03-09

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