A study on the correlation between multimorbidity and motoric cognitive risk syndrome in rural older adults
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摘要:
目的 本研究旨在调查安徽省农村老年人多重慢病与运动认知风险综合征(MCR)之间的横断面关系,探索慢性疾病数量与MCR之间的关联,以期为在农村的特定社会情境下,制定预防MCR的策略和措施提供依据。 方法 采用方便抽样方法选取安徽省六安和阜阳两地农村地区的652名老年人进行调查,开展多重慢病与MCR之间的相关性研究。其中慢性疾病状态以参与者自我报告的形式进行记录,MCR通过结合步态缓慢和主观认知下降进行评估。采用logistic回归分析研究多重慢病与MCR之间的关系。 结果 患有任何一种慢性疾病的老年人更可能患有MCR(OR=2.926,95% CI:1.256~6.816,P=0.013)。多重慢病的数量与MCR显著相关,其中患有3种慢性疾病的老年人患MCR的风险最高(OR=4.946,95% CI:1.811~13.506,P=0.002)。Logistic回归分析显示,高血压+抑郁症(OR=2.433,95% CI:1.294~4.573,P=0.006)和高血压+高脂血症+抑郁症(OR=4.632,95% CI:1.978~10.848,P<0.001)两组多重慢病模式的老年人更容易患有MCR。 结论 在安徽省农村老年人中,多重慢病与MCR具有相关性,患有MCR的概率随着慢性疾病数量的累积而增加。 Abstract:Objective To investigate the cross-sectional relationship between multimorbidity and motoric cognitive risk syndrome (MCR) among older adults in Anhui province, China. To explore the association between the number of chronic diseases and MCR in order to provide a basis for the development of strategies and measures to prevent MCR in rural areas. Methods A cross-sectional study was conducted among 652 older adults in rural areas of Lu' an and Fuyang City, Anhui Province, China, participants self-reported their chronic disease status. MCR was assessed by combining slow gait with subjective cognitive decline, and logistic regression was used to analyze the relationship between multimorbidity and MCR. Results Older adults with chronic disease had a higher likelihood of experiencing MCR (OR=2.926, 95% CI: 1.256-6.816, P=0.013). Further, the presence of three chronic diseases in older adults was associated with the highest risk of MCR (OR=4.946, 95% CI: 1.811-13.506, P=0.002). Logistic regression analysis showed that older adults with specific multimorbidity patterns, such as hypertension+depression (OR=2.433, 95% CI: 1.294-4.573, P=0.006) and hypertension+hyperlipidemia+depression (OR=4.632, 95% CI: 1.978-10.848, P<0.001), were more prone to developing MCR. Conclusion MCR is associated with multimorbidity among older adults in rural Anhui province, China. -
Key words:
- Multimorbidity /
- Motoric cognitive risk syndrome /
- The aged /
- Rural
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表 1 623名研究对象的社会人口学特征
Table 1. Sociodemographic characteristics of 623 participants
项目 人数 百分比(%) 性别 男性 284 45.6 女性 339 54.4 城市 六安 197 31.6 阜阳 426 68.4 教育程度 文盲 381 61.2 非文盲 242 38.8 社会隔离 社会隔离 260 41.7 非社会隔离 363 58.3 衰弱状态 衰弱 283 45.4 非衰弱 340 54.6 吸烟者 是 116 18.6 否 507 81.4 饮酒者 是 134 21.5 否 489 78.5 规律运动 是 455 73.0 否 168 27.0 多重慢病 是 282 45.3 否 341 54.7 MCR 是 105 16.9 否 518 83.1 表 2 慢性病状况与MCR之间的相关性
Table 2. The associations between chronic diseases status and MCR
变量 MCR OR值 95% CI P值 慢性病 否 参照组 是 2.926 1.256~6.816 0.013 慢性病数量a 无慢性病 参照组 1种慢性病 2.211 0.898~5.445 0.084 2种慢性病 3.579 1.460~8.780 0.005 3种慢性病 4.946 1.811~13.506 0.002 4种慢性病 2.067 0.490~8.713 0.322 注:aP趋势=0.006。赋值方法如下,无慢性病=0,慢性病=1;无慢性病=0,有1种慢性病=1,有2种慢性病=2,有3种慢性病=3,有4种慢性病=4。 表 3 多重慢病模式与MCR之间的相关性
Table 3. The associations between multimorbidity patterns and MCR
变量 MCR OR值 95% CI P值 多重慢病 否 参照组 是 2.068 1.255~3.408 0.004 多重慢病模式 无多重慢病组 参照组 高血压+高脂血症 1.568 0.534~4.605 0.413 高血压+糖尿病 0.940 0.257~3.436 0.926 高血压+抑郁 2.433 1.294~4.573 0.006 高脂血症+抑郁 1.411 0.263~7.568 0.688 糖尿病+抑郁 5.079 0.991~26.028 0.051 高血压+高脂血症+糖尿病 1.315 0.335~5.157 0.694 高血压+高脂血症+抑郁 4.632 1.978~10.848 <0.001 高血压+糖尿病+抑郁 1.692 0.495~5.781 0.401 高血压+高脂血症+糖尿病+抑郁 1.192 0.345~4.119 0.781 注:高脂血症+糖尿病多重慢病组合因人数较少(n=1)剔除。赋值方法如下,是=1,否=0;多重慢病模式,无多重慢病=(0,0,0,0,0,0,0,0,0),高血压+高脂血症=(1,0,0,0,0,0,0,0,0),高血压+糖尿病=(0,1,0,0,0,0,0,0,0),高血压+抑郁=(0,0,1,0,0,0,0,0,0),高脂血症+抑郁=(0,0,0,1,0,0,0,0,0),糖尿病+抑郁=(0,0,0,0,1,0,0,0,0),高血压+高脂血症+糖尿病=(0,0,0,0,0,1,0,0,0),高血压+高脂血症+抑郁=(0,0,0,0,0,0,1,0,0),高血压+糖尿病+抑郁=(0,0,0,0,0,0,0,1,0),高血压+高脂血症+糖尿病+抑郁=(0,0,0,0,0,0,0,0,1)。 -
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