MCI老年人群血清维生素D水平与认知功能及抑郁情绪的相关性研究

蔡菡; 张军; 许慧; 李世霞; 王小泉

doi:10.16766/j.cnki.issn.1674-4152.003361

MCI老年人群血清维生素D水平与认知功能及抑郁情绪的相关性研究

doi: 10.16766/j.cnki.issn.1674-4152.003361

蔡菡¹,
张军¹,
许慧²,
李世霞¹,
王小泉^1, ,

1.
芜湖市第四人民医院精神科，安徽芜湖 241002
2.
安徽中医药高等专科学校基础教学部，安徽芜湖 241002

基金项目:

安徽省高校自然科学研究项目 2023AH040381

安徽省芜湖市科技计划项目 2022cg31

详细信息

通讯作者:
王小泉，E-mail：1073018189@qq.com

中图分类号: R592
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- 被引次数: 0
出版历程
- 收稿日期: 2023-11-20
- 网络出版日期: 2024-03-27

Exploring the correlation between serum vitamin D levels, cognitive function, and depressive mood in elderly individuals with MCI

1.
Department of Psychiatry, the Fourth People' s Hospital of Wuhu, Wuhu, Anhui 241002, China

摘要

摘要: 目的探讨轻度认知功能障碍(MCI)老年人群血清维生素D水平与认知功能及抑郁情绪的相关性，为临床干预提供理论基础。方法 2023年2—8月对社区老人展开筛查，入组315例MCI受试者，采血测量维生素D水平，其中维生素D缺乏组155人和正常组160人，比较2组一般情况、简易智力状态检查量表(MMSE)、蒙特利尔认知评估量表(MoCA)、老年抑郁量表(GDS)、流调用抑郁自评量表(CES-D)评分差异。结果与正常组比较，维生素D缺乏组MMSE的即刻记忆[(9.01±1.41)分vs.(8.46±2.36)分]，计算[(3.64±1.60)分vs.(3.20±1.76)分]，回忆[2.00(1.00, 3.00)分vs.2.00(1.00, 2.00)分]，复述[1.00(0.00, 1.00)分vs.1.00(0.00, 1.00)分]，三步命令[(2.59±0.71)分vs.(2.28±0.90)分]，总分[(25.10±3.05)分vs.(23.56±3.90)分]，MoCA语言、回忆、总分均明显降低(P<0.05)。维生素D缺乏组CES-D总分[(13.10±4.12)分vs.(11.26±4.81)分]明显高于正常组(P<0.01)。维生素D水平与总体认知功能具有正相关关系(P<0.05)，与抑郁情绪存在负相关关系(P<0.05)。结论 MCI人群维生素D水平与认知功能和抑郁存在相关关系。
- 社区 /
- 轻度认知障碍 /
- 维生素D /
- 认知功能 /
- 抑郁
Abstract: Objective The objective of this study is to investigate the correlation among serum vitamin D levels, cognitive function, and depressive mood in elderly individuals with mild cognitive impairment (MCI), aiming to establish a theoretical foundation for clinical intervention. Methods Between February 2023 and August 2023, a total of 315 subjects with MCI were screened from the elderly community population. Blood samples were collected to measure vitamin D levels, with 155 subjects categorized as vitamin D deficient group and 160 subjects categorized as normal group. A comparative analysis was conducted to assess the general conditions of these two groups. Additionally, scores from the mini-mental state examination (MMSE), the Montreal cognitive assessment (MoCA), the geriatric depression scale (GDS), and centre for epidemiological studies depression scale (CES-D) were compared between the two groups. Results Compared with the normal group, the vitamin D deficient group exhibited significantly lower scores in immediate memory (9.01±1.41 vs. 8.46±2.36), calculation (3.64±1.60 vs. 3.20±1.76), memory [2.00 (1.00, 3.00) vs. 2.00 (1.00, 2.00)], repeat [1.00 (0.00, 1.00) vs. 1.00 (0.00, 1.00)], and three-step command (2.59±0.71 vs. 2.28±0.90) of MMSE. The total score (25.10±3.05 vs. 23.56±3.90), and language score of MoCA, as well as memory and total score, were also significantly lower in the vitamin D deficient group (P<0.05). Furthermore, the total score of CES-D in the vitamin D deficient group (13.10±4.12 vs. 11.26±4.81) was significantly higher (P<0.01). Correlation analysis revealed a positive association between vitamin D levels and overall cognitive function (P<0.05), while serum vitamin D levels showed a negative correlation with depressive mood (P<0.05). Conclusion Vitamin D level has been found to be associated with cognition and depression in individuals with MCI.
- Community /
- Mild cognitive impairment /
- Vitamin D /
- Cognitive function /
- Depression

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表 1 维生素D缺乏组与正常组老年人一般资料比较

Table 1. Comparison of general data between vitamin D deficiency group and normal group in the eldly

项目	缺乏组(n=155)	正常组(n=160)	统计量	P值
年龄(x±s, 岁)	72.61±5.64	71.61±5.20	1.630^a	0.104
性别(男性/女性，例)	58/97	106/54	26.220^b	<0.001
文化程度(文盲/小学/初中/高中/大专/本科，例)	39/38/42/32/4/0	22/46/58/30/2/2	-1.326^c	0.185
婚姻(已婚/丧偶，例)	125/30	138/22	1.680^b	0.195
夜眠时间(x±s, h)	6.40±1.24	6.54±1.28	1.003^a	0.317
吸烟(是/否，例)	115/40	118/42	0.008^b	0.929
饮酒(是/否，例)	117/38	110/50	1.773^b	0.183
饮茶(是/否，例)	79/76	70/90	1.645^b	0.200
锻炼(是/否，例)	75/80	60/100	3.810^b	0.054
喝牛奶(是/否，例)	91/64	106/54	1.911^b	0.167
吃鱼(是/否，例)	109/46	122/38	1.414^b	0.234
午睡(是/否，例)	66/89	84/76	3.106^b	0.078
注：^a为t值，^b为χ²值，^c为Z值。

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表 2 维生素D缺乏组与正常组老年人认知功能及抑郁情绪比较(分)

Table 2. Comparison of cognitive function and depressive mood between vitamin D deficiency group and normal group in the eldly (points)

项目	缺乏组(n=155)	正常组(n=160)	统计量	P值
MMSE
即刻记忆力(x±s)	8.46±2.36	9.01±1.41	2.520^a	0.012
计算(x±s)	3.20±1.76	3.64±1.60	2.314^a	0.021
回忆[M(P₂₅, P₇₅)]	2.00(1.00, 2.00)	2.00(1.00, 3.00)	-2.880^b	0.004
复述[M(P₂₅, P₇₅)]	1.00(0.00, 1.00)	1.00(0.00, 1.00)	-2.791^b	0.005
三步命令(x±s)	2.28±0.90	2.59±0.71	3.342^a	0.001
MMSE总分(x±s)	23.56±3.90	25.10±3.05	3.833^a	<0.001
MoCA
语言[M(P₂₅, P₇₅)]	1.00(1.00, 2.00)	2.00(1.00, 2.00)	-2.559^b	0.011
回忆[M(P₂₅, P₇₅)]	0.00(0.00, 2.00)	1.00(0.00, 3.00)	-2.497^b	0.013
MoCA总分(x±s)	15.31±5.39	18.40±4.70	3.089^a	0.002
GDS总分[M(P₂₅, P₇₅)]	8.00(5.00, 10.50)	7.00(4.00, 10.00)	-1.144^b	0.252
CES-D总分(x±s)	13.10±4.12	11.26±4.81	3.470^a	0.001
注：^a为t值，^b为Z值。

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表 3 维生素D水平与认知功能及抑郁情绪的相关性

Table 3. Association of vitamin D levels with cognitive function and depression

相关因素	维生素D3水平		维生素D总水平
相关因素	r值	P值	r值	P值
MMSE即刻记忆力	0.134	0.018	0.130	0.022
MMSE计算	0.118	0.038	0.130	0.022
MMSE回忆	0.221	<0.001	0.227	<0.001
MMSE三步命令	0.209	<0.001	0.462	<0.001
MMSE结构	0.115	0.045	0.131	0.023
MMSE总分	0.225	<0.001	0.238	<0.001
MoCA视空间	0.149	0.010	0.153	0.008
MoCA命名	0.210	<0.001	0.203	<0.001
MoCA语言	0.156	0.007	0.173	0.003
MoCA回忆	0.142	0.014	0.132	0.023
MoCA总分	0.209	<0.001	0.212	<0.001
GDS	-0.124	0.037	-0.118	0.047
CES-D	-0.258	<0.001	-0.253	<0.001

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