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MCI老年人群血清维生素D水平与认知功能及抑郁情绪的相关性研究

蔡菡 张军 许慧 李世霞 王小泉

蔡菡, 张军, 许慧, 李世霞, 王小泉. MCI老年人群血清维生素D水平与认知功能及抑郁情绪的相关性研究[J]. 中华全科医学, 2024, 22(2): 187-190. doi: 10.16766/j.cnki.issn.1674-4152.003361
引用本文: 蔡菡, 张军, 许慧, 李世霞, 王小泉. MCI老年人群血清维生素D水平与认知功能及抑郁情绪的相关性研究[J]. 中华全科医学, 2024, 22(2): 187-190. doi: 10.16766/j.cnki.issn.1674-4152.003361
CAI Han, ZHANG Jun, XU Hui, LI Shixia, WANG Xiaoquan. Exploring the correlation between serum vitamin D levels, cognitive function, and depressive mood in elderly individuals with MCI[J]. Chinese Journal of General Practice, 2024, 22(2): 187-190. doi: 10.16766/j.cnki.issn.1674-4152.003361
Citation: CAI Han, ZHANG Jun, XU Hui, LI Shixia, WANG Xiaoquan. Exploring the correlation between serum vitamin D levels, cognitive function, and depressive mood in elderly individuals with MCI[J]. Chinese Journal of General Practice, 2024, 22(2): 187-190. doi: 10.16766/j.cnki.issn.1674-4152.003361

MCI老年人群血清维生素D水平与认知功能及抑郁情绪的相关性研究

doi: 10.16766/j.cnki.issn.1674-4152.003361
基金项目: 

安徽省高校自然科学研究项目 2023AH040381

安徽省芜湖市科技计划项目 2022cg31

详细信息
    通讯作者:

    王小泉,E-mail:1073018189@qq.com

  • 中图分类号: R592

Exploring the correlation between serum vitamin D levels, cognitive function, and depressive mood in elderly individuals with MCI

  • 摘要:   目的  探讨轻度认知功能障碍(MCI)老年人群血清维生素D水平与认知功能及抑郁情绪的相关性,为临床干预提供理论基础。  方法  2023年2—8月对社区老人展开筛查,入组315例MCI受试者,采血测量维生素D水平,其中维生素D缺乏组155人和正常组160人,比较2组一般情况、简易智力状态检查量表(MMSE)、蒙特利尔认知评估量表(MoCA)、老年抑郁量表(GDS)、流调用抑郁自评量表(CES-D)评分差异。  结果  与正常组比较,维生素D缺乏组MMSE的即刻记忆[(9.01±1.41)分vs.(8.46±2.36)分],计算[(3.64±1.60)分vs.(3.20±1.76)分],回忆[2.00(1.00, 3.00)分vs.2.00(1.00, 2.00)分],复述[1.00(0.00, 1.00)分vs.1.00(0.00, 1.00)分],三步命令[(2.59±0.71)分vs.(2.28±0.90)分],总分[(25.10±3.05)分vs.(23.56±3.90)分],MoCA语言、回忆、总分均明显降低(P<0.05)。维生素D缺乏组CES-D总分[(13.10±4.12)分vs.(11.26±4.81)分]明显高于正常组(P<0.01)。维生素D水平与总体认知功能具有正相关关系(P<0.05),与抑郁情绪存在负相关关系(P<0.05)。  结论  MCI人群维生素D水平与认知功能和抑郁存在相关关系。

     

  • 表  1  维生素D缺乏组与正常组老年人一般资料比较

    Table  1.   Comparison of general data between vitamin D deficiency group and normal group in the eldly

    项目 缺乏组(n=155) 正常组(n=160) 统计量 P
    年龄(x±s, 岁) 72.61±5.64 71.61±5.20 1.630a 0.104
    性别(男性/女性,例) 58/97 106/54 26.220b <0.001
    文化程度(文盲/小学/初中/高中/大专/本科,例) 39/38/42/32/4/0 22/46/58/30/2/2 -1.326c 0.185
    婚姻(已婚/丧偶,例) 125/30 138/22 1.680b 0.195
    夜眠时间(x±s, h) 6.40±1.24 6.54±1.28 1.003a 0.317
    吸烟(是/否,例) 115/40 118/42 0.008b 0.929
    饮酒(是/否,例) 117/38 110/50 1.773b 0.183
    饮茶(是/否,例) 79/76 70/90 1.645b 0.200
    锻炼(是/否,例) 75/80 60/100 3.810b 0.054
    喝牛奶(是/否,例) 91/64 106/54 1.911b 0.167
    吃鱼(是/否,例) 109/46 122/38 1.414b 0.234
    午睡(是/否,例) 66/89 84/76 3.106b 0.078
    注:at值,b为χ2值,cZ值。
    下载: 导出CSV

    表  2  维生素D缺乏组与正常组老年人认知功能及抑郁情绪比较(分)

    Table  2.   Comparison of cognitive function and depressive mood between vitamin D deficiency group and normal group in the eldly (points)

    项目 缺乏组(n=155) 正常组(n=160) 统计量 P
    MMSE
        即刻记忆力(x±s) 8.46±2.36 9.01±1.41 2.520a 0.012
        计算(x±s) 3.20±1.76 3.64±1.60 2.314a 0.021
        回忆[M(P25, P75)] 2.00(1.00, 2.00) 2.00(1.00, 3.00) -2.880b 0.004
        复述[M(P25, P75)] 1.00(0.00, 1.00) 1.00(0.00, 1.00) -2.791b 0.005
        三步命令(x±s) 2.28±0.90 2.59±0.71 3.342a 0.001
        MMSE总分(x±s) 23.56±3.90 25.10±3.05 3.833a <0.001
    MoCA
        语言[M(P25, P75)] 1.00(1.00, 2.00) 2.00(1.00, 2.00) -2.559b 0.011
        回忆[M(P25, P75)] 0.00(0.00, 2.00) 1.00(0.00, 3.00) -2.497b 0.013
        MoCA总分(x±s) 15.31±5.39 18.40±4.70 3.089a 0.002
        GDS总分[M(P25, P75)] 8.00(5.00, 10.50) 7.00(4.00, 10.00) -1.144b 0.252
        CES-D总分(x±s) 13.10±4.12 11.26±4.81 3.470a 0.001
    注:at值,bZ值。
    下载: 导出CSV

    表  3  维生素D水平与认知功能及抑郁情绪的相关性

    Table  3.   Association of vitamin D levels with cognitive function and depression

    相关因素 维生素D3水平 维生素D总水平
    r P r P
    MMSE即刻记忆力 0.134 0.018 0.130 0.022
    MMSE计算 0.118 0.038 0.130 0.022
    MMSE回忆 0.221 <0.001 0.227 <0.001
    MMSE三步命令 0.209 <0.001 0.462 <0.001
    MMSE结构 0.115 0.045 0.131 0.023
    MMSE总分 0.225 <0.001 0.238 <0.001
    MoCA视空间 0.149 0.010 0.153 0.008
    MoCA命名 0.210 <0.001 0.203 <0.001
    MoCA语言 0.156 0.007 0.173 0.003
    MoCA回忆 0.142 0.014 0.132 0.023
    MoCA总分 0.209 <0.001 0.212 <0.001
    GDS -0.124 0.037 -0.118 0.047
    CES-D -0.258 <0.001 -0.253 <0.001
    下载: 导出CSV
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  • 收稿日期:  2023-11-20
  • 网络出版日期:  2024-03-27

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