新型脂肪因子在糖尿病周围神经病变中的作用及研究进展

陈明飞; 陈宗存

doi:10.16766/j.cnki.issn.1674-4152.004460

新型脂肪因子在糖尿病周围神经病变中的作用及研究进展

doi: 10.16766/j.cnki.issn.1674-4152.004460

陈明飞,
陈宗存^,

海南医科大学第二附属医院内分泌科，海南海口 570311

基金项目:

海南省卫生健康科技创新联合项目面上项目 WSJK2024MS200

详细信息

通讯作者:
陈宗存，E-mail：422731749@qq.com

中图分类号: R587.2
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- 被引次数: 0
出版历程
- 收稿日期: 2025-03-22
- 网络出版日期: 2026-08-31

Department of Endocrinology, the Second Affiliated Hospital of Hainan Medical University, Haikou, Hainan 570311, China

CHEN Mingfei,
CHEN Zongcun^,

Graduate School of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, China

摘要

摘要: 糖尿病周围神经病变(DPN)是糖尿病最常见的慢性并发症之一，常导致疼痛、感觉异常和功能丧失，严重影响患者生活质量。随着全球糖尿病患病率持续上升，DPN防控形势严峻，其机制研究备受关注。近年来，Apelin、脂联素、脂质运载蛋白-2、网膜素-1及Nesfatin-1等新型脂肪因子作为脂肪组织分泌的生物活性分子和潜在生物标志物，在代谢性疾病中的作用被深入探索。研究表明，这些新型脂肪因子的表达水平变化及其信号通路与DPN的发生发展密切相关，可能通过代谢异常、炎症反应及神经损伤等多种机制参与DPN进程。然而，目前关于新型脂肪因子在DPN中具体机制及其临床应用的研究仍显不足。本文旨在总结这些脂肪因子在DPN中的作用机制、影响因素及最新研究进展，探讨新型脂肪因子在DPN早期诊断与干预中的价值，并为未来研究提供理论基础和临床参考。
- 糖尿病周围神经病变 /
- 新型脂肪因子 /
- Apelin /
- 脂联素 /
- 脂质运载蛋白-2 /
- 网膜素-1 /
- Nesfatin-1
Abstract: Diabetic peripheral neuropathy (DPN) is one of the most common chronic complications of diabetes, often leading to pain, sensory abnormalities, and loss of function, which seriously affects the quality of life of patients. With the continuous increase in the global prevalence of diabetes, the prevention and control situation of DPN is severe, and research on its mechanism has attracted much attention. In recent years, novel adipokines such as Apelin, adiponectin, lipocalin-2, omentin-1, and Nesfatin-1, as bioactive molecules secreted by adipose tissue and potential biomarkers, have been extensively explored for their roles in metabolic diseases. Studies have shown that changes in the expression levels of these novel adipokines and their signaling pathways are closely related to the occurrence and development of DPN, and they may participate in the process of DPN through multiple mechanisms such as metabolic abnormalities, inflammatory responses, and nerve damage. However, current research on the specific mechanisms and clinical applications of novel adipokines in DPN is still insufficient. This article aims to summarize the mechanisms of action, influencing factors, and the latest research progress of these adipokines in DPN, explore the value of novel adipokines in the early diagnosis and intervention of DPN, and provide a theoretical basis and clinical reference for future research.
- Diabetic peripheral neuropathy /
- Novel adipokines /
- Apelin /
- Adiponectin /
- Lipocalin-2 /
- Omentin-1 /
- Nesfatin-1

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