Abstract: Objective To analyze clinical haemostatic effect and incidences of adverse reactions of Esomeprazole treatment for patients who suffered from peptic ulcer bleeding because of taking nonsteroidal anti-inflammatory drugs. Methods From January,2012 to June,2015,496 cases of peptic ulcer with upper gastrointestinal haemorrhage who visited our digestive department receiving treatment were randomly divided into two groups:Esomeprazole group(280 patients) and control group of Omeprazole(216 patients) were treated with different treatment regimen.The efficacy,adverse reactions of test group and control group were compared. Results The clinical total effective rate of test group and control group were 97.85% and 88.88%,respectively.Test group was significantly higher than control group (chi-square test,P<0.05).The average disappearance time of clinical symptoms in test group and control group were (3.2±1.5)d and (4.8±1.3)d,respectively.Test group was significantly shorter than control group by analysis of variance(P<0.05).There was no significant difference in adverse reaction rate between test group and control group (chi-square test,P>0.05). Conclusion Esomeprazole combined with hemocoagulase treatment gastrointestinal bleeding caused by nonsteroidal anti-inflammatory drugs is significantly better than omeprazole combined with hemocoagulase.Test group,which has hemostatic effect exactly,can effectively shorten the time of the patients stay in EICU and is the ideal disposal measures.