Abstract: Objective To investigate the prognostic difference of colorectal cancer patients with or without lymphovascular invasion after the surgical treatment. Methods The clinicopathological data of colorectal cancer patients in our hospital between 2005 and 2010 were retrospectively analyzed.The relationship between lymphovascular invasion and clinical parameters were analyzed with ANOVA.Univariate and Cox multivariate analysis were also conducted to identify the prognostic factor of colorectal cancer patients.Kaplan-Meie was performed to investigate the correlation between lymphovascular invasion-positive and the prognosis of patients. Results ANOVA showed that lymphovascular invasion closely related to tumor differentiation(P=0.01),lymphatic metastasis(P<0.001),TNM(P<0.001) and survival rate(P<0.001).Cox regression analysis showed that lymphovascular invasion(P=0.001),lymphatic metastasis(P=0.025),TNM stage(P<0.001) were the independent prognostic factor for colorectal cancer patients.Kaplan-Meie analysis of lymphovascular invasion demonstrated that the patients with lymphovascular invasion-positive had a significantly shorter survival time than those with lymphovascular invasion-negative patients(P<0.001). Conclusion Lymphovascular invasion had a compact relationship with lymphatic metastasis,and the positive-lymphovascular invasion might be a potential independent prognostic factor for patients with colorectal cancer.The more efficient therapy and method for colorectal cancer patients with positive lymphovacular invasion should be adopt to improve living standard and prolong survival time.