Abstract: Objective To study the clinical etiology of pointed condyloma with pseudocondyloma features. Methods Patients with pointed condyloma (15 cases),pseudocondyloma (15 cases),and pointed condyloma with pseudocondyloma features (25 cases) in our hospital from January,2013 to December,2015 were retrospectively analyzed.The clinical features,pathology,and HPV type of 3 groups were compared and analyzed,to study the clinical etiology of pointed condyloma with pseudocondyloma features. Results Warty lesions of typical pointed condyloma showed rough,easily rupture small reddish pimples;Warty lesions of pseudocondyloma lesions mostly showed 1-2 mm cluster size pimples on inside of the labia minora at both sides;Warty lesions of pointed condyloma with pseudocondyloma features was the same with pseudocondyloma lesions.Acetic acid white experiment of pointed condyloma showed positive,acetic acid white experiment of pseudocondyloma showed negative,and acetic acid white experiment of pointed condyloma with pseudocondyloma features showed weakly positive.All pointed condyloma showed HPV-positive[4 kinds low-risk HPV (6,11,43,55),10 kinds high-risk HPV (16,18,33,39,51,52,53,58,59,66)],one HPV subtypes 4 cases,two HPV subtypes 6 cases,three HPV subtypes 3 cases,four HPV subtypes 2 cases;pseudocondyloma HPV tests were all negative;pointed condyloma with pseudocondyloma features showed HPV-positive[3 kinds low-risk HPV (6,11,81),7 kinds high-risk type HPV (16,18,33,35,51,53,58)],one HPV subtypes 8 cases,two HPV subtypes 12 cases,3 HPV subtypes 3 cases,four HPV subtypes 2 cases. Conclusion Patients with pseudocondyloma features might contain high-risk HPV infection of the genital warts.