Clinical effect of Weifuchun tablets combined with omeprazole enteric-coated capsules in the treatment of functional dyspepsia
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摘要:
目的 探讨胃复春片联合奥美拉唑肠溶胶囊治疗功能性消化不良患者的临床效果,及其对血清胃蛋白酶原、胃泌素17的影响。 方法 采用随机数字表法将余姚市中医医院2021年10月—2022年12月收治的128例功能性消化不良患者分为胃复春组与莫沙必利组, 每组各64例。莫沙必利组给予奥美拉唑联合莫沙必利片治疗,胃复春组给予奥美拉唑联合胃复春片治疗,连续治疗4周后,比较2组患者的治疗效果、血清胃蛋白酶原、胃泌素17水平等。 结果 治疗4周后,胃复春组(87.50%, 56/64)的治疗总有效率高于莫沙必利组(71.88%, 46/64,χ2=4.827,P < 0.05);胃复春组胃蛋白酶原Ⅰ[(113.20±10.21)μg/L]水平高于莫沙必利组[(98.26±9.64)μg/L,P < 0.05],胃蛋白酶原Ⅱ[(17.21±2.58)μg/L]、胃泌素17[(15.31±2.09)pmol/L]水平均低于莫沙必利组[(20.31±3.11)μg/L、(18.22±2.67)pmol/L,P < 0.05]。 结论 胃复春片联合奥美拉唑肠溶胶囊治疗功能性消化不良患者临床症状改善明显,且能纠正血清胃蛋白酶原、胃泌素17水平的异常,提高患者的预后生活质量。 Abstract:Objective To explore the clinical effect of Weifuchun tablets combined with omeprazole enteric-coated capsules on patients with functional dyspepsia and their influence on serum pepsinogen and gastrin-17 levels. Methods Using a random number table, 128 patients diagnosed with functional dyspepsia at Yuyao Hospital of Traditional Chinese Medicine between October 2021 and December 2022 were divided into two groups: Weifuchun group and Mosapride group, eaching consisting of 64 cases. The mosapride group was given a combination of omeprazole and Mosapride tablets, while the Weifuchun group was given a combination of omeprazole and Weifuchun tablets. After 4 weeks of continuous treatment, the therapeutic effect, serum pepsinogen, and gastrin-17 levels were compared between the two groups. Results After 4 weeks of treatment, the Weifuchun group demonstrated a higher total effective rate (87.50%, 56/64) compared to the Mosapride group (71.88%, 46/64), with a statistically significant difference (χ2=4.827, P < 0.05). The Weifuchun group also exhibited higher levels of pepsinogen Ⅰ [(113.20±10.21) μg/L] compared to the Moxapride group [(98.26±9.64) μg/L, P < 0.05]. Moreover, the Weifuchun group showed lower levels of pepsinogen Ⅱ[(17.21±2.58) μg/L] and gastrin-17 [(15.31±2.09) pmol/L] compared to the Mosapride group [(20.31±3.11) μg/L, (18.22±2.67) pmol/L, P < 0.05]. Conclusion The combination of Weifuchun tablets and omeprazole enteric-coated capsules significantly improves the clinical symptoms of patients with functional dyspepsia. It effectively corrects abnormal levels of serum pepsinogen and gastrin-17, leading to improved prognosis and enhanced quality of life for patients. -
Key words:
- Functional dyspepsia /
- Weifuchun tablets /
- Serum pepsinogen /
- Omeprazole /
- Gastrin-17
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表 1 2组功能性消化不良患者中医症状积分比较(x ± s,分)
Table 1. Comparison of TCM symptom scores between two groups of patients with functional dyspepsia(x ± s, points)
组别 例数 餐后饱胀不适 早饱感 中上腹痛 中上腹烧灼感 治疗前 4周后 治疗前 4周后 治疗前 4周后 治疗前 4周后 莫沙必利组 64 7.57±1.68 4.46±0.81b 7.01±1.67 4.78±0.94b 6.83±1.28 4.18±0.67b 7.16±1.21 3.86±1.03b 胃复春组 64 7.61±1.25 1.82±0.35b 7.19±1.42 1.41±0.39b 7.05±1.41 2.02±0.57b 6.87±1.79 1.24±0.33b 统计量 0.153a 91.701c 0.657a 156.152c 0.924a 40.898c 1.074a 81.055c P值 0.879 < 0.001 0.512 < 0.001 0.357 < 0.001 0.285 < 0.001 注:a为t值,c为F值;与同组治疗前比较,bP < 0.05。 表 2 2组功能性消化不良患者中医症候疗效比较[例(%)]
Table 2. Comparison of curative effect of TCM symptoms between two groups of patients with functional dyspepsia[cases(%)]
组别 例数 显效 有效 无效 总有效 莫沙必利组 64 20(31.25) 26(40.63) 18(28.12) 46(71.88) 胃复春组 64 31(48.44) 25(39.06) 8(12.50) 56(87.50) 注:2组疗效比较,Z=6.238,P=0.442;2组总有效率比较,χ2=4.827,P=0.028。 表 3 2组功能性消化不良患者生活质量改善情况比较(x ± s,分)
Table 3. Comparison of quality of life improvement between two groups of patients with functional dyspepsia (x ± s, points)
组别 例数 躯体功能 精神状况 社会认知 治疗前 4周后 治疗前 4周后 治疗前 4周后 莫沙必利组 64 60.52±3.26 78.56±7.26b 35.12±3.65 57.15±6.22b 55.26±4.31 67.45±6.20b 胃复春组 64 61.27±4.52 85.26±6.88b 36.84±4.11 63.25±5.86b 54.67±5.12 74.52±5.21b 统计量 1.077a 27.143c 2.503a 44.386c 0.705a 49.512c P值 0.284 < 0.001 0.014 < 0.001 0.482 < 0.001 注:a为t值,c为F值;与同组治疗前比较,bP < 0.05。 表 4 2组功能性消化不良患者血清胃蛋白酶原、胃泌素17水平比较(x ± s)
Table 4. Comparison of serum pepsinogen and gastrin 17 levels between two groups of patients with functional dyspepsia(x ± s)
组别 例数 胃蛋白酶原Ⅰ(μg/L) 胃蛋白酶原Ⅱ(μg/L) 胃泌素17(pmol/L) 治疗前 4周后 治疗前 4周后 治疗前 4周后 莫沙必利组 64 80.11±6.21 98.26±9.64b 25.61±4.12 20.31±3.11b 21.03±3.26 18.22±2.67b 胃复春组 64 79.68±7.16 113.20±10.21b 26.02±3.26 17.21±2.58b 20.86±2.88 15.31±2.09b 统计量 0.363a 52.753c 0.624a 17.283c 0.313a 21.890c P值 0.717 < 0.001 0.534 < 0.001 0.755 < 0.001 注:a为t值,c为F值;与同组治疗前比较,bP < 0.05。 -
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