脂肪细胞因子在卵巢衰老中的作用

谭晨蕾; 李琰华

doi:10.16766/j.cnki.issn.1674-4152.003474

脂肪细胞因子在卵巢衰老中的作用

doi: 10.16766/j.cnki.issn.1674-4152.003474

谭晨蕾¹,
李琰华^2, ,

1.
浙江中医药大学第二临床医学院，浙江杭州 310053
2.
浙江中医药大学附属第二医院全科医学科，浙江杭州 310005

详细信息

通讯作者:
李琰华，E-mail：Liyanhua0330@163.com

中图分类号: R711.75
计量
- 文章访问数: 56
- HTML全文浏览量: 18
- PDF下载量: 4
- 被引次数: 0
出版历程
- 收稿日期: 2023-11-29
- 网络出版日期: 2024-05-29

The role of adipocytokines in ovarian senescence

TAN Chenlei¹,
LI Yanhua^{2
, ,}

1.
The Second Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China

摘要

摘要: 卵巢衰老的特点是卵母细胞或卵泡的数量和质量下降，引起生育能力的下降。随着社会经济水平的不断发展以及我国三孩政策的颁布，不断推迟的生育年龄与不断衰退的卵泡池之间的矛盾与日俱增。高龄生育力下降也成了一种严峻的挑战。如何延缓卵巢衰老，满足育龄期女性的生育需求，成为近年来医学研究人员的关注热点。目前常见的脂肪细胞因子是主要由脂肪细胞产生的具有生物活性的分子，它们参与机体的能量代谢及内外环境平衡等多种生理过程，并可能参与糖尿病、动脉粥样硬化等一系列肥胖相关疾病的发生。而在女性生殖系统中，一些常见的脂肪细胞因子，如瘦素、内脂素、脂联素、趋化素、脂肪炎症因子等通过内分泌、旁分泌和自分泌途径相互作用，调控卵泡的质量及生长发育。瘦素被发现在一定浓度范围内可以促进卵泡的成熟，过高或过低的浓度都可能对卵母细胞造成不利影响。内脂素在相关研究中被认为可以刺激卵巢血管生成，从而提升生育能力。脂联素可以通过相关通路调节颗粒细胞和卵丘细胞的代谢和凋亡，从而保护卵泡的发育。趋化素抑制颗粒细胞增殖，诱导颗粒细胞凋亡，并抑制卵泡刺激素引起的颗粒细胞产生雌二醇和孕酮。脂肪细胞因子引起的炎症可能是年龄相关调节卵泡数量的机制之一。本文通过查阅相关文献，尝试探讨常见脂肪细胞因子在卵巢衰老中所起的作用。
- 卵巢衰老 /
- 瘦素 /
- 内脂素 /
- 脂联素
Abstract: Ovarian senescence is characterized by a decline in the number and quality of oocytes or follicular pools, causing a decline in fertility. With the continuous development of social and economic levels and the promulgation of China ' s three-child policy, there is a growing tension between the ever-delayed reproductive age and the ever-declining follicular pool. Declining fertility at an advanced age is also a serious challenge. How to delay ovarian senescence and meet the reproductive needs of women of childbearing age has become a focus of medical researchers in recent years. At present, common adipocytokines are biologically active molecules mainly produced by adipocytes. They are involved in a variety of physiological processes such as energy metabolism and internal and external environment balance of the body and may be involved in the occurrence of a series of obesity-related diseases such as diabetes and atherosclerosis. In the female reproductive system, some common adipocytokines, such as leptin, visfatin, adiponectin, chemokine, and adipoinflammatory factors, regulate follicle quality and growth and development through endocrine, paracrine, and autocrine pathways. Leptin has been found to promote follicle maturation within a certain range of concentrations, and either too high or too low concentrations may cause adverse effects on oocytes. Visfatin has been reported to stimulate ovarian angiogenesis, thereby enhancing fertility. Adiponectin can regulate the metabolism and apoptosis of granulosa cells and cumulus cells through related pathways, thereby protecting follicle development. Chemerin inhibits granulosa cell proliferation, induces apoptosis, and inhibits follicle-stimulating hormone-induced production of estradiol and progesterone by granulosa cells. Inflammation caused by adipocytokines may be one of the mechanisms involved in the age-related regulation of follicle number. Through reviewing relevant literature, this paper attempts to explore the role of common adipocytokines in ovarian aging, to provide some theoretical references for general practitioners in the health care of women of reproductive age.
- Ovarian senescence /
- Leptin /
- Visfatin /
- Adiponectin

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参考文献(42)

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