Effects of compound Danshen dripping pills combined omeprazole on peptic ulcer with diabetes mellitus and its impact on the hemorheology

Objective To investigate the effects of Danshen Dripping Pill combined Omeprazole on hemorheology, Nitric oxide (NO) and Endothelin (ET) of patients with diabetes mellitus and peptic ulcer. Methods Total 132 cases of peptic ulcer with diabetes mellitus in our hospital between January, 2015 and June, 2017 were randomly divided into two groups, with 66 cases in each group. The control group was given omeprazole, and the observation group was added compound Danshen Dripping Pill. After 4 week's treatment, the clinical efficacy, hemorheology[whole blood high shear viscosity, low blood viscosity, plasma specific viscosity], serum NO and serum ET levels of the two groups were compared. The effects and potential mechanism of Danshen Dripping Pill combined Omeprazole on patients with diabetes mellitus and peptic ulcer were analyzed. Results The total effective rate of the observation group was 95.45%, which was significantly higher than that of the control group (83.33%), P<0.05. Before the treatment, there was no significantly difference in hemorheology, NO and ET between the two groups (P>0.05). After the treatment, the high shear viscosity, low blood viscosity and plasma specific viscosity of the two groups were significantly decreased (P<0.05), and high shear viscosity, low blood viscosity and plasma specific viscosity of the observation group were significantly lower than those of the control group (P<0.05). After the treatment, the serum NO levels of both groups were significantly increased (P<0.05), and NO level of the observation group was significantly higher than that of the control group (P<0.05). After the treatment, the serum ET levels of the two groups were significantly decreased (P<0.05), and ET level of the observation group was significantly lower than that of the control group (P<0.05). Conclusion Danshen Dropping Pill combined Omeprazole can effectively improve peptic ulcer with diabetes mellitus. The mechanism might be related to the improvement of microcirculation and regulation of serum NO and ET.