Objective To investigate the situation of serotype distribution of
Streptococcus pneumoniae (
S. pneumoniae) isolated from Chinese hospitalized children and to evaluate the value of pneumococcal conjugate vaccine in the prevention of
S. pneumoniae infection.
Methods S. pneumoniae strains isolated from clinical specimens of 751 children hospitalized in Beijing Children's Hospital between March, 2013 and December, 2017 were studied. The serum type was detected by capsule swelling experiment.
Results A total of 751 isolates of
S. pneumoniae were collected, including 684 non-invasive strains and 67 invasive strains. The non-invasive strains were mainly isolated from respiratory secretions (52.3%) and bronchoalveolar lavage fluid (44.4%). The invasive strains were mainly isolated from blood (50.7%), pleural effusion (25.4%) and cerebrospinal fluid (23.9%). The common serotypes of the 751 strains were 19F (37.0%), 19A (14.2%), 23F (9.5%), 14 (7.9%), 6A (7.7%) and 6B (5.2%), accounting for 81.5%. The coverage rates of PCV10, PCV13 and PPV23 were 61.5%, 84.3% and 82.6%, respectively. The most common serotypes of non-invasive strains were 19F (37.3%), 19A (13.5%), 23F (9.5%), 6A (8.0%), 14 (7.0%) and 6B (5.6%). The coverage rates of PCV10 and PCV13 were 60.8% and 83.0%, respectively. The most common serotypes of invasive strains were 19F (34.3%), 19A (22.4%), 14 (16.4%), 23F (9.0%), 6A (4.5%), 9V (3.0%) and 1 (3.0%). The coverage rates of PCV10 and PCV13 were 68.7% and 95.5%, respectively.
Conclusion Serotype 19F, 19A, 23F, 14, 6A and 6B, all of which were included in PCV13, were the common types among the pneumococcal strains isolated from hospitalized children in Beijing Children's Hospital. The coverage rate of PCV13 is more than 80%, and the coverage rate is higher in the invasive infection strains, indicating the promotion of PCV13 can prevent the overwhelming majority of
S. pneumoniae infection.