Study on the involvement of MEK/ERK signaling pathway in cisplatin-resistance in ovarian cancer

Objective The present research tried to explore the involvement of MEK/ERK signaling pathway in cisplatin-resistance in ovarian cancer. Methods 92 cases of cisplatin-resistance ovarian cancer patients in our hospital from February, 2015 to August, 2017 were enrolled in this part.The expression of MEK/ERK signaling pathway related proteins was detected by ELISA. Ninety cases of ovarian cancer patients without cisplatin-resistance at the same period were taken as control. Results The result revealed that the expression of MEK/ERK signaling pathway related proteins Ras, Raf, MEK and ERK1/2 as well as PI3K/AKT proteins were increased in observation group than control (P<0.05). At the mean time, the Bcl2 were increased (P<0.05) while the expression of Bax and caspase-9 were decreased (P<0.05) in observation group than control with statistical differences. Conclusion MEK/ERK signaling pathway as well as abnormal expression of PI3K and AKT are involved in cisplatin-resistance in ovarian cancer patients.