Clinical efficacy of oxycodone hydrochloride injection for preemptive analgesia in radical gastrectomy and its effect on stress response of patients

Objective To observe the clinical effect of preemptive analgesia with oxycodone hydrochloride on perioperative pain management in patients undergoing radical gastrectomy. Methods A total of 130 patients with gastric cancer underwent radical gastrectomy in Zhejiang Cancer Hospital from March 2017 to March 2019 were selected and divided into study group (n=65) and control group (n=65) according to random number table method. All patients underwent radical gastrectomy under general anesthesia. Oxycodone hydrochloride preemptive analgesia was given in the study group 30 minutes before skin incision, while dezocine preemptive analgesia was given in the control group. The hemodynamic parameters such as HR, MAP and SpO₂ were measured at different anesthesia time points. The levels of serum stress response factors were detected, and the VAS scores were compared. The dosage of self-controlled analgesics, recovery time and extubation time were recorded, and the adverse reactions were observed. Results There was no significant difference in HR, MAP and SpO₂ between the study group and the control group at T0-T4 (all P>0.05). The resting VAS scores and cough VAS scores of the study group were lower than those of the control group at 6, 12, 24 and 36 hours after operation (all P<0.001). The serum E, NE and Cor levels of the study group were lower than those of the control group at 24 hours after operation (all P<0.001). The dosage of sufentanil for patient-controlled analgesia after operation in the study group (52.28±8.61) μg was less than that in the control group (74.37±12.49) μg (P<0.001). The overall incidence of adverse reactions in the study group (7.69%) was lower than that in the control group (23.08%, χ²=5.909, P=0.015). Conclusion Oxycodone hydrochloride for preemptive analgesia in radical gastrectomy can effectively maintain hemodynamic stability during anesthesia, inhibit post-operative stress response, relieve pain response intensity, reduce the dosage of analgesics, and reduce the incidence of adverse reactions rate.