Volume 19 Issue 1
Jan.  2021
Turn off MathJax
Article Contents
Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(1): 20-23
WANG Jin, PENG Wan-sheng, ZHOU Rui, WANG Ya-ming, XYU Jia-li. Analysis of risk factors of children with severe hand-foot-mouth disease[J]. Chinese Journal of General Practice, 2021, 19(1): 20-23. doi: 10.16766/j.cnki.issn.1674-4152.001719
Citation: WANG Jin, PENG Wan-sheng, ZHOU Rui, WANG Ya-ming, XYU Jia-li. Analysis of risk factors of children with severe hand-foot-mouth disease[J]. Chinese Journal of General Practice, 2021, 19(1): 20-23. doi: 10.16766/j.cnki.issn.1674-4152.001719
shu

Analysis of risk factors of children with severe hand-foot-mouth disease

doi: 10.16766/j.cnki.issn.1674-4152.001719
  • 1.

    Graduate School of Bengbu Medical College, Bengbu, Anhui 233003, China

Funds:

 2016QK092

 Byycx1974

  • Received Date: 2020-05-28
    Available Online: 2022-02-19
    Abstract
  •   Objective  To observe the primary laboratory examination results of children with severe hand-foot-mouth disease (HFMD), determine their risk factors and establish a prediction model to provide early diagnosis and timely HFMD treatment.   Methods  Children with HFMD (including clinical diagnosis cases and confirmed cases) were included in the study. They were admitted to the First Affiliated Hospital of Bengbu Medical College from January 2019 to December 2019. The clinical symptoms, signs and major laboratory indicators were analysed, and statistically significant terms were further processed via multifactor logistic regression to build a regression model. ROC curves were drawn to evaluate the predictive effect of the model. Data were analysed using SPSS 26.0 software.   Results  The clinical data of 109 HFMD cases (including 41 mild cases and 68 severe cases), showed that body temperature of ≥ 38.9 ℃ (OR=2.943, 95% CI: 1.099-7.884), poor spirit (OR=5.899, 95% CI: 2.130-16.339), increased peripheral blood white blood cells (OR=4.386, 95% CI: 1.420-13.541) and abnormal electroencephalogram (OR=4.502, 95% CI: 1.714-11.821) were independent risk factors for severe HFMD. The regression equation of the prediction model was Logit (P)=-2.893+1.079X1+1.775X2+1.478X3+1.504X4. The sensitivity of the model was 61.0%, and its specificity was 83.8%. The area under the curve corresponding to the ROC curve was 0.843 (95% CI: 0.768-0.917).   Conclusion  Body temperature of ≥ 38.9 ℃, poor spirit, increased peripheral blood white blood cells and abnormal electroencephalogram are independent risk factors for severe HFMD. These risk factors can be used to establish a predictive logistic regression model for severe HFMD.

     

    • FullText(HTML)
  • loading
    • References(20)
  • [1]
    李兴旺. 手足口病诊疗指南(2018年版)[J]. 中华传染病杂志, 2018, 36(5): 257-263. doi: 10.3760/cma.j.issn.1000-6680.2018.05.001
    [2]
    成怡冰, 周崇臣, 宋春兰, 等. 危重型手足口病的影响因素分析及风险评分系统的建立研究[J]. 中国全科医学, 2018, 21(13): 1573-1579. doi: 10.3969/j.issn.1007-9572.2018.13.013
    [3]
    QIU J, LU X, LIU X, et al. Derivation and validation of a mortality risk score for severe hand, foot and mouth disease in China[J]. Sci Rep, 2017, 7(1): 3371. doi: 10.1038/s41598-017-02658-4
    [4]
    张立霞, 马进. 重型手足口病临床特征及预警指标分析[J]. 蚌埠医学院学报, 2018, 43(5): 631-632, 636. https://www.cnki.com.cn/Article/CJFDTOTAL-BANG201805020.htm
    [5]
    公共卫生科学数据中心. 手足口病[DB/OL]. [2020-05-10]. http://www.phsciencedata.cn/Share/ky_sjml.jsp?id=b9c93769-3e0f-413a-93c1-027d2009d8bc.
    [6]
    AW-YONG K L, NIKNADIA N M N, TAN C W, et al. Immune responses against enterovirus A71 infection: implications for vaccine success(Review)[J]. Rev Med Virol, 2019, 29(5): 2073. http://www.ncbi.nlm.nih.gov/pubmed/31369184
    [7]
    沈嬿, 陈中新, 胡建国, 等. EV71-IgM抗体检测在婴幼儿肠道病毒感染早期诊治和防控中的意义[J]. 中华全科医学, 2018, 16(5): 708-711. https://www.cnki.com.cn/Article/CJFDTOTAL-SYQY201805009.htm
    [8]
    薛爱丽, 任祥欣, 贾静, 等. 101例手足口病重症病例流行学和临床特征分析[J]. 临床研究, 2019, 27(10): 6-8. https://www.cnki.com.cn/Article/CJFDTOTAL-LCYN201910005.htm
    [9]
    LI Z, CUI B, LIU X, et al. Virucidal activity and the antiviral mechanism of acidic polysaccharides against Enterovirus 71 infection in vitro[J]. Microbiol Immunol, 2020, 64(3): 189-201. doi: 10.1111/1348-0421.12763
    [10]
    GAO E, WU S, XU Q, et al. Enterovirus type 71-immunized chicken egg yolk immunoglobulin has cross antiviral activity against coxsackievirus A16 in vitro[J]. Exp Ther Med, 2019, 18(1): 332-341. http://www.ingentaconnect.com/content/sp/etm/2019/00000018/00000001/art00041
    [11]
    ROSENFELD-YEHOSHUA N, BARKAN S, ABU-KISHK I, et al. Hyperpyrexia and high fever as a predictor for serious bacterial infection (SBI) in children-a systematic review[J]. Eur J Pediatr, 2018, 177(3): 337-344. doi: 10.1007/s00431-018-3098-x
    [12]
    FLETCHER T, BLEEKER-ROVERS C, BEECHING N. Fever[J]. Medicine, 2017, 45(3): 177-183. doi: 10.1016/j.mpmed.2016.12.013
    [13]
    ZHANG W, HUANG Z, HUANG M, et al. Predicting Severe Enterovirus 71-infected hand, foot, and mouth disease: cytokines and chemokines[J]. Mediators Inflamm, 2020. DOI: 10.1155/2020/9273241.
    [14]
    何春卉. EV71感染手足口病患儿血清IL-6、IL-13水平变化及其原因[J]. 山东医药, 2017, 57(29): 78-80. doi: 10.3969/j.issn.1002-266X.2017.29.026
    [15]
    LIN W, SU Y, JIANG M, et al. Clinical features for 89 deaths of hand, foot and mouth disease in Guangxi, China, 2014[J]. Int J Infect Dis, 2017, 64: 15-19. doi: 10.1016/j.ijid.2017.08.016
    [16]
    王猛, 孙丽敏, 刘洋, 等. 重症手足口病危险因素分析[J]. 泰山医学院学报, 2019, 40(10): 796-797. doi: 10.3969/j.issn.1004-7115.2019.10.033
    [17]
    张中馥, 张楠, 李清华, 等. 动态监测血清CRP、PCT水平对手足口病病情转归时的监测意义[J]. 河北医药, 2018, 40(13): 2030-2032. doi: 10.3969/j.issn.1002-7386.2018.13.029
    [18]
    李亚玲. NLR、PLR联合CRP检测对手足口病患儿的临床价值[J]. 检验医学与临床, 2018, 15(17): 2582-2584, 2588. doi: 10.3969/j.issn.1672-9455.2018.17.016
    [19]
    邓杨富, 欧阳辉, 陆桂宁. 手足口病患儿发生急性呼吸衰竭的预判性研究[J]. 海南医学院学报, 2018, 24(9): 942-944. https://www.cnki.com.cn/Article/CJFDTOTAL-HNYY201809012.htm
    [20]
    SUI M, HUANG X, LI Y, et al. Application and comparison of laboratory parameters for forecasting severe hand-foot-mouth disease using logistic regression, discriminant analysis and decision tree[J]. Clin Lab, 2016, 62(6): 1023-1031. http://europepmc.org/abstract/MED/27468564
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Figures(3)  / Tables(4)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (192) PDF downloads(3) Cited by()
    Proportional views
    Related

    Address：No. 287, Changhuai Road, Bengbu, Anhui Province, 233004, P.R.ChinaphoneNo：0552-3066635； 0552-3051890Email：zhqkyx@163.com

    Copyright © Chinese Journal of General Practice皖ICP备2020018345号-2

    Supported by: Beijing Renhe Information Technology Co., Ltd.    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return