Clinical effect of the treatment of acute lung injury with rhubarb by nasal feeding based on the theory of 'lung and large intestine inside and outside'

JIANG Huan-huan; LI Zhi-jun

doi:10.16766/j.cnki.issn.1674-4152.001729

Volume 19 Issue 1

Jan. 2021

Turn off MathJax

Article Contents

Article Navigation > Chinese Journal of General Practice > 2021 > 19(1): 55-58

JIANG Huan-huan, LI Zhi-jun. Clinical effect of the treatment of acute lung injury with rhubarb by nasal feeding based on the theory of 'lung and large intestine inside and outside'[J]. Chinese Journal of General Practice, 2021, 19(1): 55-58. doi: 10.16766/j.cnki.issn.1674-4152.001729

Citation:

JIANG Huan-huan, LI Zhi-jun. Clinical effect of the treatment of acute lung injury with rhubarb by nasal feeding based on the theory of 'lung and large intestine inside and outside'[J]. Chinese Journal of General Practice, 2021, 19(1): 55-58. doi: 10.16766/j.cnki.issn.1674-4152.001729

Citation:

JIANG Huan-huan, LI Zhi-jun. Clinical effect of the treatment of acute lung injury with rhubarb by nasal feeding based on the theory of 'lung and large intestine inside and outside'[J]. Chinese Journal of General Practice, 2021, 19(1): 55-58. doi: 10.16766/j.cnki.issn.1674-4152.001729

PDF( 1113 KB)

Clinical effect of the treatment of acute lung injury with rhubarb by nasal feeding based on the theory of 'lung and large intestine inside and outside'

doi: 10.16766/j.cnki.issn.1674-4152.001729

JIANG Huan-huan¹
, LI Zhi-jun^{2
,
,}

1.
Department of Respiratory Medicine, Wenzhou Integrated Traditional Chinese and Western Medicine Hospital, Wenzhou, Zhejiang 325000, China

Funds:

LY18H290008

Received Date: 2020-05-19
Available Online: 2022-02-19

Abstract

Abstract

Objective To observe the effect of nasal feeding rhubarb on the improvement of clinical symptoms and prognosis of patients with acute lung injury (ALI). Methods A total of 128 patients with ALI were selected as the research subjects. All subjects were divided into the control group (n=64) and the research group (n=64) using the random number table method. The patients in the control group were given routine treatment, whereas the patients in the research group were given adjuvant treatment of rhubarb by nasal feeding on the basis of routine treatment. The hs-CRP, TNF-α, IL-6 and IL-8 levels were measured before and after treatment. The time of mechanical ventilation and hospitalisation were recorded. The changes of respiratory frequency, arterial oxygen partial pressure and oxygenation index were counted before and after treatment, and the incidence of ARDS and death was observed during the treatment. Results After treatment, the hs-CRP, TNF-α, IL-6 and IL-8 levels in the research group were significantly lower than those in the control group (all P < 0.05). The respiratory rate in the research group [(24.81±2.64) times/min] was significantly lower than that in the control group [(27.64±2.79) times/min], whereas PaO₂ and oxygenation index in the research group [(78.35±6.63) mm Hg and (314.20±42.17) mm Hg, respectively] were significantly higher than those in the control group [(70.26±6.21) mm Hg and (263.07±39.60) mm Hg, respectively; all P < 0.05]. The duration of mechanical ventilation in the study group [(4.27±1.39) days] was significantly shorter than that in the control group [(6.95±1.81) days, t=-4.971; P < 0.001]. The incidence and mortality of ARDS in the study group (18.75% and 3.12%) were significantly lower than those in the control group (39.06% and 14.06%, χ²=6.425, 4.873; all P < 0.05). Conclusion Rhubarb by nasal feeding can inhibit the inflammatory response of patients with ALI, promote the recovery of respiratory function and blood gas index and prevent the deterioration of the disease.
- Acute lung injury,
- Nasal feeding,
- Rhubarb,
- Lung and large intestine inside and outside,
- Inflammatory reaction,
- Clinical effect

FullText(HTML)

References(19)

References

[1]	刘婷, 赵德育. 活性氧作用于急性肺损伤/急性呼吸窘迫综合征的研究进展[J]. 国际呼吸杂志, 2019, 39(24): 1890-1894. doi: 10.3760/cma.j.issn.1673-436X.2019.24.010
[2]	伍冬冬, 潘频华, 覃庆武. 急性肺损伤/急性呼吸窘迫综合征发病机制研究进展[J]. 中华结核和呼吸杂志, 2015, 38(7): 524-527. doi: 10.3760/cma.j.issn.1001-0939.2015.07.013
[3]	EL-AGAMY D S, MOHAMED G A, AHMED N, et al. Protective anti-inflammatory activity of tovophyllin A against acute lung injury and its potential cytotoxicity to epithelial lung and breast carcinomas[J]. Inflammopharmacology, 2020, 28(1): 153-163. doi: 10.1007/s10787-019-00609-1
[4]	中华医学会呼吸病学分会. 急性肺损伤/急性呼吸窘迫综合征的诊断标准(草案)[J]. 中华结核和呼吸杂志, 2000, 23(4): 203. https://www.cnki.com.cn/Article/CJFDTOTAL-ZHJH200004005.htm
[5]	廖世均, 梁卫东. 急性肺损伤保护措施进展研究[J]. 临床肺科杂志, 2018, 23(7): 1321-1325. doi: 10.3969/j.issn.1009-6663.2018.07.043
[6]	CHEPURNOVA D A, SAMOILOVA E V, ANISIMOV A A, et al. Compounds of IL-6 receptor complex during acute lung injury[J]. Bull Exp Biol Med, 2018, 164(5): 609-611. doi: 10.1007/s10517-018-4042-9
[7]	LAI W Y, WANG J W, HUANG B T, et al. A novel TNF-α-targeting aptamer for TNF-α-mediated acute lung injury and acute liver failure[J]. Theranostics, 2019, 9(6): 1741-1751. doi: 10.7150/thno.30972
[8]	张璐璐, 陈亮, 杜丽, 等. 乌司他丁联合参麦注射液治疗创伤后早期急性肺损伤疗效及对血清TNF-α、IL-6水平的影响[J]. 现代生物医学进展, 2017, 17(33): 6540-6543, 6548. https://www.cnki.com.cn/Article/CJFDTOTAL-SWCX201733032.htm
[9]	甘惠玲, 赵双平. APACHEⅡ评分对重症肺炎致急性肺损伤患者撤机结局的预测价值[J]. 内科急危重症杂志, 2019, 25(2): 123-125. https://www.cnki.com.cn/Article/CJFDTOTAL-NKJW201902010.htm
[10]	黄庆生, 张丽霞, 李燕, 等. 乌司他丁联合无创通气治疗急性呼吸窘迫综合征的临床研究[J]. 中国临床药理学杂志, 2016, 32(14): 1268-1271. https://www.cnki.com.cn/Article/CJFDTOTAL-GLYZ201614006.htm
[11]	苏景深, 刘恩顺, 赵鑫民. 急性肺损伤/急性呼吸窘迫综合征中医药治疗研究进展[J]. 吉林中医药, 2019, 39(5): 696-700. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYJL201905037.htm
[12]	童晓萍, 王维亮, 何德平. 肺部感染所致急性肺损伤/急性呼吸窘迫综合征中医病因病机特点及从肠论治理论探讨[J]. 新中医, 2016, 48(8): 1-3. https://www.cnki.com.cn/Article/CJFDTOTAL-REND201608001.htm
[13]	郝京霞, 张英谦, 黄波, 等. 肺与大肠相表里应用到肺疾病治疗中的理论研究进展[J]. 中华中医药杂志, 2017, 32(4): 1688-1690. https://www.cnki.com.cn/Article/CJFDTOTAL-BXYY201704083.htm
[14]	陈秀华. 大承气汤治疗急性呼吸窘迫综合征疗效及对血清白细胞介素表达的影响[J]. 中华中医药学刊, 2018, 36(2): 456-459. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYHS201802053.htm
[15]	郭丽纳, 孙燕妮. 大黄素对急性肺损伤保护作用研究进展[J]. 中国中医急症, 2017, 26(4): 663-665. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYJZ201704031.htm
[16]	王亦君, 冯舒涵, 程锦堂, 等. 大黄蒽醌类化学成分和药理作用研究进展[J]. 中国实验方剂学杂志, 2018, 24(13): 227-234. https://www.cnki.com.cn/Article/CJFDTOTAL-ZSFX201813036.htm
[17]	陈子彬, 丰浩荣, 王祥和. 乌司他丁联合大黄对创伤后急性肺损伤的治疗效果[J]. 解放军医药杂志, 2015, 27(2): 69-72. doi: 10.3969/j.issn.2095-140X.2015.02.019
[18]	刘汉伟, 唐纪文, 饶李亮. 大承气汤在急性肺损伤/急性呼吸窘迫综合征患者机械通气治疗中的应用价值[J]. 现代中西医结合杂志, 2016, 25(34): 3792-3794, 3876. https://www.cnki.com.cn/Article/CJFDTOTAL-XDJH201634011.htm
[19]	王宏飞, 王勇强, 高红梅, 等. 大承气汤在急性肺损伤/急性呼吸窘迫综合征患者机械通气治疗中的应用[J]. 山东医药, 2015, 55(12): 33-34. doi: 10.3969/j.issn.1002-266X.2015.12.15

Relative Articles

Supplements(0)

Cited By

Proportional views

Proportional views

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Tables(3)

Get Citation

PDF

XML

Article Metrics

Article views (133) PDF downloads(2)

Clinical effect of the treatment of acute lung injury with rhubarb by nasal feeding based on the theory of 'lung and large intestine inside and outside'

doi: 10.16766/j.cnki.issn.1674-4152.001729

Abstract

References

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

Clinical effect of the treatment of acute lung injury with rhubarb by nasal feeding based on the theory of 'lung and large intestine inside and outside'

doi: 10.16766/j.cnki.issn.1674-4152.001729

Abstract

References

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

Export File

Citation

Format

Content