Clinical effect of <i>Xinshen Jieyu</i> Decoction in the imbalance of Th17/Treg and Barthel index in the moderate or severe post-stroke depression patients

HAN Zhen-xiang; QI Li-li; HOU Zhen-zhen; ZHOU Yi-xin; LIU Ai-hua

doi:10.16766/j.cnki.issn.1674-4152.001771

Volume 19 Issue 2

Feb. 2021

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Article Navigation > Chinese Journal of General Practice > 2021 > 19(2): 217-220

HAN Zhen-xiang, QI Li-li, HOU Zhen-zhen, ZHOU Yi-xin, LIU Ai-hua. Clinical effect of Xinshen Jieyu Decoction in the imbalance of Th17/Treg and Barthel index in the moderate or severe post-stroke depression patients[J]. Chinese Journal of General Practice, 2021, 19(2): 217-220. doi: 10.16766/j.cnki.issn.1674-4152.001771

Citation:

HAN Zhen-xiang, QI Li-li, HOU Zhen-zhen, ZHOU Yi-xin, LIU Ai-hua. Clinical effect of Xinshen Jieyu Decoction in the imbalance of Th17/Treg and Barthel index in the moderate or severe post-stroke depression patients[J]. Chinese Journal of General Practice, 2021, 19(2): 217-220. doi: 10.16766/j.cnki.issn.1674-4152.001771

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Clinical effect of Xinshen Jieyu Decoction in the imbalance of Th17/Treg and Barthel index in the moderate or severe post-stroke depression patients

doi: 10.16766/j.cnki.issn.1674-4152.001771

1.
Neurorehabilitation Department, the Seventh People's Hospital of Shanghai University of TCM, Shanghai 200137, China

Funds:

国中医药人教发[2017]29号

ZY3-RCPY-1-1001

PDZY-2019-0703

Received Date: 2020-03-28
Available Online: 2022-02-19

Abstract

Abstract

Objective To investigate the clinical effect of Xinshen Jieyu Decoction in the moderate or severe post-stroke depression patients. Methods Ninety post-stroke depression patients were included in Seventh People's Hospital of Shanghai University of TCM, which was conducted from January 2014 to January 2018. The patients were randomized to receive Xinshen Jieyu Decoction combined with sertraline vs control sertraline group over 8 weeks. The HAMD was the primary outcome measure. As secondary aims, several biomarkers, such as BDNF, Treg and Th17 were investigated. Results The 2 group did not differ with the baseline severity of depression. Hamilton Depression scale (HAMD) score and Barthel Index in both groups were significantly improved (all P < 0.05). Meanwhile, HAMD score and Bathel Index were significantly more improved in the treatment group than in the control group after 4 weeks (all P < 0.05). The biomarkers, such as BDNF, Treg, Th17 and Treg/Th17 were significant difference before and after treatment (all P < 0.05) and these biomarkers were significantly better than those of the control group (all P < 0.05). BDNF level (27.31±5.20) and Treg level (6.52±0.93) in treatment group after treatment were higher than those in control group (23.03±5.62, 4.52±1.51). Th17 level (0.30±0.16) and Th17/Treg level (0.10±0.06) in treatment group after treatment were higher than those in control group (0.41±0.27, 0.16±0.07). Conclusion Imbalance of Th17/Treg may be a potent pathogenesis of PSD. Xinshen Jieyu Decoction combined with sertraline hydrochloride is more effective and safer than sertraline hydrochloride alone in the PSD treatment.
- Xinshen Jieyu Decoction,
- Post-stroke depression,
- Immunological imbalance

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References(25)

References

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Clinical effect of Xinshen Jieyu Decoction in the imbalance of Th17/Treg and Barthel index in the moderate or severe post-stroke depression patients

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Clinical effect of Xinshen Jieyu Decoction in the imbalance of Th17/Treg and Barthel index in the moderate or severe post-stroke depression patients

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