Volume 19 Issue 2
Feb.  2021
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XU Ya-xuan, XU Li, WEI Dao-xiang. Comparative study of the clinical efficacy of acetylglutamine and paroxetine in treating generalised anxiety disorder[J]. Chinese Journal of General Practice, 2021, 19(2): 277-279. doi: 10.16766/j.cnki.issn.1674-4152.001787
Citation: XU Ya-xuan, XU Li, WEI Dao-xiang. Comparative study of the clinical efficacy of acetylglutamine and paroxetine in treating generalised anxiety disorder[J]. Chinese Journal of General Practice, 2021, 19(2): 277-279. doi: 10.16766/j.cnki.issn.1674-4152.001787
shu

Comparative study of the clinical efficacy of acetylglutamine and paroxetine in treating generalised anxiety disorder

doi: 10.16766/j.cnki.issn.1674-4152.001787

  • Department of Neurology, the First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China

Funds:

 SK2018A0181

  • Received Date: 2020-09-21
    Available Online: 2022-02-19
    Abstract
  •   Objective  To compare and analyse the clinical efficacy of aceglutamide and paroxetine in treating generalised anxiety disorder.  Methods  A total of 30 patients with anxiety disorders admitted to the First Affiliated Hospital of Bengbu Medical College from March 2019 to November 2019 were collected and divided into study group and control group by random number table method, with 15 patients per group. No statistically significant difference existed between the two groups in general information such as age, gender, course of disease, and other basic information which could be compared and analysed. Patients in the study group were treated with aceglutamide, whereas those in the control group were treated with paroxetine. Changes in the condition of patients in the two groups after 7 and 14 days of treatment were compared using Hamilton Anxiety scale scores.  Results  The anxiety scores of the control group before treatment, 7 days after treatment and 14 days after treatment were 21.33±3.42, 17.40±3.38 and 15.20±2.51 respectively, while those of the study group were 22.47±4.03, 16.53±3.52 and 11.80±2.47 respectively. The anxiety scores of the study group were significantly reduced compared with those of the control group (P < 0.05). The total effective rate of the control group was significantly lower than that of the study group (P=0.039).  Conclusion  Aceglutamide and paroxetine have obvious therapeutic effects in treating generalised anxiety disorder, but the former has better anti-anxiety effect, with faster onset, safety and reliability, which is more worthy of clinical application.

     

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