Volume 19 Issue 3
Mar.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(3): 358-361
ZHANG Miao-yu, LUO Ke-xue, GAO Yan-fei, LI Hong-chun, ZHONG Ling-ling. Analysis of the correlation between serum indexes and the degree of frailty in elderly inpatients[J]. Chinese Journal of General Practice, 2021, 19(3): 358-361. doi: 10.16766/j.cnki.issn.1674-4152.001809
Citation: ZHANG Miao-yu, LUO Ke-xue, GAO Yan-fei, LI Hong-chun, ZHONG Ling-ling. Analysis of the correlation between serum indexes and the degree of frailty in elderly inpatients[J]. Chinese Journal of General Practice, 2021, 19(3): 358-361. doi: 10.16766/j.cnki.issn.1674-4152.001809
shu

Analysis of the correlation between serum indexes and the degree of frailty in elderly inpatients

doi: 10.16766/j.cnki.issn.1674-4152.001809

  • Department of Cadre Health Care, Tongde Hospital, Hangzhou, Zhejiang 310012, China

Funds:

 2020KY511

  • Received Date: 2020-04-29
    Available Online: 2022-02-19
    Abstract
  •   Objective   To analyze the correlation between serum 25-hydroxyvitamin D [25(OH)D], interleukin-10 (IL-10), D-dimer (D-D) levels and the degree of frailty in elderly hospitalized frail patients.   Methods   A total of 420 elderly inpatients in our hospital were selected as the research objects, including 47 in the frailty group and 373 in the non-frailty group. The serum 25(OH)D, IL-10 and D-D levels of patients with different degrees of debilitating and re-admitted and non-re-admitted patients were compared between the two groups. The influencing factors of the occurrence of frailty in elderly inpatients were analyzed, and the correlation between serum indexes and the degree of frailty and the predictive value of re-admission to elderly frail patients were discussed.   Results   Age, length of hospital stays, 25(OH)D, IL-10, and D-D were all important risk factors for frailty in elderly hospitalized patients (OR=4.847, 5.887, 0.580, 4.820, 5.120, all P < 0.05). Serum 25(OH)D level (r=-0.415) was negatively correlated with the degree of frailty in elderly hospitalized patients with frailty. IL-10 (r=0.379) and D-D (r=0.392) levels were positively correlated with the degree of frailty (P < 0.05). The area under the curve predicted by the combination of serum 25(OH)D, IL-10, and D-D for re-admission of elderly hospitalized patients with frailty was 0.844, the sensitivity was 80.96%, and the specificity was 80.77%.   Conclusion   The abnormal expression of serum 25(OH)D, IL-10 and D-D levels is related to the degree of frailty. The combination of the three can provide evidence-based guidance for predicting the re-admission of elderly hospitalized patients with frailty.

     

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