Volume 19 Issue 3
Mar.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(3): 368-370, 374
ZHANG Fu-long, QIU Zhao-lei, WANG Zhen-jie, JI Zhong, ZHAO Heng, CHENG Feng, ZHAO De-jun. The clinical significance of heparin-binding protein combined with CRP in the early evaluation of severe acute pancreatitis[J]. Chinese Journal of General Practice, 2021, 19(3): 368-370, 374. doi: 10.16766/j.cnki.issn.1674-4152.001812
Citation: ZHANG Fu-long, QIU Zhao-lei, WANG Zhen-jie, JI Zhong, ZHAO Heng, CHENG Feng, ZHAO De-jun. The clinical significance of heparin-binding protein combined with CRP in the early evaluation of severe acute pancreatitis[J]. Chinese Journal of General Practice, 2021, 19(3): 368-370, 374. doi: 10.16766/j.cnki.issn.1674-4152.001812
shu

The clinical significance of heparin-binding protein combined with CRP in the early evaluation of severe acute pancreatitis

doi: 10.16766/j.cnki.issn.1674-4152.001812

  • Department of Emergency Surgery, the First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China

Funds:

 KJ2015B113by

 BYTM2019017

 BYKF1768

 R2018004

  • Received Date: 2020-05-27
    Available Online: 2022-02-19
    Abstract
  •   Objective   To investigate the correlation study and clinical significance of heparin-binding protein (HBP) combined with C-reactive protein (CRP) in evaluating the severity of the disease in patients with severe acute pancreatitis(SAP).   Methods   A total of 71 patients with acute pancreatitis admitted to the Emergency Department of the First Affiliated Hospital of Bengbu Medical College from October 2018 to February 2020 were collected. According to the severity of the disease, 37 patients with SAP and 34 patients with non-SAP patients were classified according to the diagnostic criteria of severe acute pancreatitis. The general clinical data of the two groups of patients were recorded, HBP and CRP levels at admission were detected, and APACHEⅡ scores were performed. Pearson correlation analysis and operating characteristic curve (ROC) were used to evaluate HBP, CRP and the combination of the two in evaluating the clinical value and significance of the disease in patients with severe acute pancreatitis.   Results   The general clinical data of the two groups of patients were not statistically significant. The levels of HBP and CRP were related to ApacheⅡ score (r=0.759, 0.365, all P < 0.05). According to ROC curve, the area under curve of HBP, CRP and HBP+CRP were 0.841, 0.792 and 0.869, respectively.   Conclusion   HBP and CRP are positively correlated with the severity of early acute pancreatitis, and the correlation between HBP is higher than that of CRP. Both HBP and CRP can predict SAP well, and the sensitivity and specificity of the combined prediction are high. Based on the prediction of a single index, this study shows that HBP combined with CRP detection has a high clinical guiding significance in the early evaluation of severe acute pancreatitis.

     

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