Volume 19 Issue 3
Mar.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(3): 413-415,470
LI Ruo-qing, MAO Mei, CUI Yuan-ting, JIANG Yi, XIE Qin-li, YANG Qiao, ZHOU Min, TANG Yu-ping. Effects of glycolipid metabolism and blood uric acid level on serum alpha-fetoprotein concentration in patients with metabolic syndrome[J]. Chinese Journal of General Practice, 2021, 19(3): 413-415,470. doi: 10.16766/j.cnki.issn.1674-4152.001824
Citation: LI Ruo-qing, MAO Mei, CUI Yuan-ting, JIANG Yi, XIE Qin-li, YANG Qiao, ZHOU Min, TANG Yu-ping. Effects of glycolipid metabolism and blood uric acid level on serum alpha-fetoprotein concentration in patients with metabolic syndrome[J]. Chinese Journal of General Practice, 2021, 19(3): 413-415,470. doi: 10.16766/j.cnki.issn.1674-4152.001824
shu

Effects of glycolipid metabolism and blood uric acid level on serum alpha-fetoprotein concentration in patients with metabolic syndrome

doi: 10.16766/j.cnki.issn.1674-4152.001824
  • 1.

    Department of General Medicine, Central Hospital of Chongqing University Chongqing Emergency Medical Center, Chongqing 400014, China

Funds:

 81900761

 2020FYYX077

  • Received Date: 2020-08-12
    Available Online: 2022-02-19
    Abstract
  •   Objective  To study the relationship between metabolic parameters and serum alpha-fetoprotein (AFP) of patients with metabolic syndrome (MS) and to clarify the influence of metabolic parameters on AFP, in order to provide reference for MS patients in cancer prevention and treatment.  Methods  General information of 415 MS patients and 227 non-MS people who participated in physical examination at Central Hospital of Chongqing University from June 2017 to June 2020 were collected. Abdominal circumference, systolic blood pressure, diastolic blood pressure, AFP, fasting blood glucose (FBS), glycated hemoglobin (HbA1c), alanine aminotransferase (ALT), aspartate aminotransferase (AST), total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL), low density lipoprotein (LDL), urea nitrogen (BUN), serum creatinine (Cr), blood uric acid (UA), β2-microglobulin and cystatin-C were measured. Differences in the above parameters between patients with MS and non-MS were compared. The parameters of different AFP concentrations in MS patients were compared and the relationship between AFP and parameters in patients with MS were analyzed.  Results  The serum AFP concentration in the MS group was significantly higher than that in the non-MS group (P < 0.001). When the FBS, HbA1c, TC, LDL, and UA of MS patients were high, the serum AFP concentration matched corresponds to the high concentration level (P < 0.001), showing a significant positive correlation (P < 0.001). FBS (β'=0.460, P < 0.001), HbA1c (β'=0.212, P < 0.001), UA (β'=0.348, P < 0.001) were independently correlated with serum AFP concentrations.  Conclusion  Glycolipid metabolism and blood uric acid levels in MS patients may affect serum AFP concentration, and this influence was more significant when glucose metabolism and blood uric acid were abnormal.

     

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