Volume 19 Issue 3
Mar.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(3): 454-458
LIU Xin-xin, GAO Chun-ming, LIU Chuan-miao. Clinical characteristics of primary biliary cholangitis and RPR value in diagnosing cirrhosis[J]. Chinese Journal of General Practice, 2021, 19(3): 454-458. doi: 10.16766/j.cnki.issn.1674-4152.001834
Citation: LIU Xin-xin, GAO Chun-ming, LIU Chuan-miao. Clinical characteristics of primary biliary cholangitis and RPR value in diagnosing cirrhosis[J]. Chinese Journal of General Practice, 2021, 19(3): 454-458. doi: 10.16766/j.cnki.issn.1674-4152.001834
shu

Clinical characteristics of primary biliary cholangitis and RPR value in diagnosing cirrhosis

doi: 10.16766/j.cnki.issn.1674-4152.001834

  • Department of Infectious Diseases, the First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China

Funds:

 KJ2017A247

  • Received Date: 2020-09-11
    Available Online: 2022-02-19
    Abstract
  •   Objective  To investigate the clinical features of primary biliary cholangitis (PBC) and the value of red blood cell distribution width-to-platelet ratio (RPR) in diagnosing PBC progression to cirrhosis, as well as to improve the level of diagnosis and treatment of the disease by clinicians.  Methods  From January 2014 to December 2019, 61 patients were diagnosed as PBC in the Outpatient and Inpatient Department of the First Affiliated Hospital of Bengbu Medical College. The clinical data of the patients were retrospectively analysed. According to the diagnostic criteria of cirrhosis, it was divided into cirrhosis and non-cirrhosis groups. Blood routine, biochemical indices, RPR values, immunoglobulin, and complement levels were compared between the two groups. The diagnostic value of RPR for PBC cirrhosis was judged by the area under the working characteristic curve (AUC).  Results  Amongst the 61 patients with PBC, 47 were female (77.05%). The main clinical manifestations were jaundice (44.26%) and abdominal distension (24.59%). Sjogren's syndrome was the most common extrahepatic autoimmune disease. A total of 56 cases (91.80%) had abnormal liver function, primarily GGT increase. The positive rate of anti-mitochondrial antibody (AMA) and/or AMA-M2 was 93.44%. Significant differences were observed in RDW, PLT, RPR, and complement C3 and C4 between cirrhotic and non-cirrhotic groups. The AUC value of RPR in diagnosing liver cirrhosis was 0.705 (95% CI: 0.567-0.843; P=0.008). The best value was 0.471, and the sensitivity and specificity were 52.20% and 81.60%, respectively.  Conclusion  PBC usually occurs in middle-aged women, and jaundice is the most common clinical manifestation. The increase in ALP and GGT and the positive AMA are the main characteristics of the disease. Sjogren's syndrome is the most commonly associated extrahepatic autoimmune disease. RPR has a high specificity in diagnosing PBC progression to cirrhosis and can be combined with other non-invasive serological indicators to help evaluate the disease progress.

     

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