Volume 19 Issue 4
Apr.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(4): 534-537
Ll Jing, ZHE Jian-qing, LUO Juan-juan, ZHANG Su-yun, LIU Mei-li. Relationship between circadian rhythm of blood pressure and carotid atherosclerosis in the elderly with hypertension[J]. Chinese Journal of General Practice, 2021, 19(4): 534-537. doi: 10.16766/j.cnki.issn.1674-4152.001854
Citation: Ll Jing, ZHE Jian-qing, LUO Juan-juan, ZHANG Su-yun, LIU Mei-li. Relationship between circadian rhythm of blood pressure and carotid atherosclerosis in the elderly with hypertension[J]. Chinese Journal of General Practice, 2021, 19(4): 534-537. doi: 10.16766/j.cnki.issn.1674-4152.001854
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Relationship between circadian rhythm of blood pressure and carotid atherosclerosis in the elderly with hypertension

doi: 10.16766/j.cnki.issn.1674-4152.001854

  • Department of Cardiology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China

Funds:

 81800390

  • Received Date: 2020-12-01
    Available Online: 2022-02-16
    Abstract
  •   Objective  This study aimed to investigate the relationship between circadian rhythm of blood pressure and carotid atherosclerosis in elderly patients with hypertension.  Methods  A total of 128 patients with senile hypertension, who were undergoing treatment in the First Affiliated Hospital of Xi'an Jiaotong University from February 2019 to February 2020, were selected as the research object. On the basis of the 24 h ambulatory blood pressure monitoring results, the patients were divided into the dipper hypertension group (32 cases) and abnormal circadian rhythm (96 cases), and abnormal circadian rhythm was then divided into the non-dipper hypertension group (68 cases) and the reverse dipper hypertension group (28 cases). The intima-media thickness (IMT) and plaque occurrence in the left and right common carotid artery in each group were measured, and the 24-h systolic blood pressure, 24-h diastolic blood pressure, daytime systolic blood pressure, daytime diastolic blood pressure, nocturnal diastolic blood pressure systolic blood pressure of each group were measured, and the general clinical data and relevant biochemical indicators were collected. The clinical indicators of patients in each group were compared.  Results  Nocturnal systolic blood pressure and nocturnal diastolic blood pressure in patients with abnormal circadian rhythm were significantly higher than those in the dipper hypertension group (all P < 0.01). The incidence of plaque in patients with abnormal circadian rhythm was significantly higher than that of the dipper hypertension group (P < 0.01). The IMT values of the left and right sides of patients with abnormal circadian rhythm were significantly higher than those of the dipper hypertension group (all P < 0.01). The nocturnal systolic blood pressure and nocturnal diastolic blood pressure were significantly higher in the anti-arytenoid group than in the non-arytenoid group (all P < 0.01). The detection rate of left common carotid artery plaque and left IMT in the non-dipper hypertension and reverse dipper hypertension groups was significantly higher than those in the right side of the same group (all P < 0.05).  Conclusion  The circadian rhythm of blood pressure in elderly patients with hypertension is significantly different between nocturnal systolic blood pressure and diastolic blood pressure. The circadian rhythm of blood pressure is related to carotid atherosclerosis, and abnormal circadian rhythm of blood pressure causes more damage to target organs. Moreover, abnormal circadian rhythm of blood pressure of non -dipper hypertension and reverse dipper hypertension patients causes more damage to left carotid intima than right.

     

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