Volume 19 Issue 4
Apr.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(4): 561-563, 692
JIANG Bo, SHI Peng, LIU Dong-liang, SANG Qing-qing, SONG Chuan-wang, SANG Dao-qian. Application of serum albumin, globulin and creatinine in predicting the severity of Guillain-Barré syndrome[J]. Chinese Journal of General Practice, 2021, 19(4): 561-563, 692. doi: 10.16766/j.cnki.issn.1674-4152.001861
Citation: JIANG Bo, SHI Peng, LIU Dong-liang, SANG Qing-qing, SONG Chuan-wang, SANG Dao-qian. Application of serum albumin, globulin and creatinine in predicting the severity of Guillain-Barré syndrome[J]. Chinese Journal of General Practice, 2021, 19(4): 561-563, 692. doi: 10.16766/j.cnki.issn.1674-4152.001861
shu

Application of serum albumin, globulin and creatinine in predicting the severity of Guillain-Barré syndrome

doi: 10.16766/j.cnki.issn.1674-4152.001861
  • 1.

    Department of Neurology, the First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China

Funds:

 1708085MH218

  • Received Date: 2020-07-17
    Available Online: 2022-02-16
    Abstract
  •   Objective  To explore the application of serum albumin, globulin and creatinine to predict the severity of Guillain-Barré syndrome (GBS).  Methods  A total of 106 patients with GBS treated in the Department of Neurology, the first affiliated Hospital of Bengbu Medical College from June 2016 to May 2020 were selected. Hughes functional score was used to compare the differences of albumin, globulin and creatinine between the two groups. Spearman correlation analysis was used to analyze the correlation between the levels of albumin, globulin, creatinine and the severity of disease in patients with GBS. The globulin and creatinine related to the severity of the disease were selected and analyzed by ROC curve.  Results  The levels of serum albumin (40.12±4.43) g/L and creatinine (63.47±11.64) μmol/L in GBS patients were lower than those in healthy controls [(47.42±4.14) g/L, (83.96±31.00) μmol/L, all P < 0.05], while the levels of globulin (29.94±5.68) g/L were higher than those in healthy controls (24.58±6.17) g/L, P < 0.05. The levels of globulin and creatinine in patients with GBS were correlated with the severity of the disease (r=0.353, P < 0.001; r=0.323, P < 0.001). The ROC curve showed that the area under the curve of globulin predicting GBS severe group was 0.699 (95% CI: 0.602-0.784). The area under the curve predicted by creatinine in GBS severe group was 0.671 (95% CI: 0.573-0.760).  Conclusion  The level of globulin in patients with GBS is positively correlated with the severity of the disease, while the level of creatinine is negatively correlated with the severity of the disease. Globulin and creatinine have certain value in evaluating the severity of GBS.

     

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