Volume 19 Issue 4
Apr.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(4): 568-571
HE Cheng-cheng, JIN Guo-xi, BI Ya-xin. Expression of B cell activating factor and interleukin-21 in the plasma of patients with Hashimoto's thyroiditis[J]. Chinese Journal of General Practice, 2021, 19(4): 568-571. doi: 10.16766/j.cnki.issn.1674-4152.001863
Citation: HE Cheng-cheng, JIN Guo-xi, BI Ya-xin. Expression of B cell activating factor and interleukin-21 in the plasma of patients with Hashimoto's thyroiditis[J]. Chinese Journal of General Practice, 2021, 19(4): 568-571. doi: 10.16766/j.cnki.issn.1674-4152.001863
shu

Expression of B cell activating factor and interleukin-21 in the plasma of patients with Hashimoto's thyroiditis

doi: 10.16766/j.cnki.issn.1674-4152.001863

  • Department of Endocrinology, the First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China

Funds:

 KJ2019ZD29

  • Received Date: 2020-08-31
    Available Online: 2022-02-16
    Abstract
  •   Objective  To investigate the expression of human B cell activating factor (BAFF) and interleukin-21 (IL-21) in the plasma of patients with Hashimoto's thyroiditis (HT) and explore their roles in the pathogenesis of HT.  Methods  Patients with HT in the Endocrinology Clinic of The First Affiliated Hospital of Bengbu Medical College from December 2019 to June 2020 were selected as the observation group (HT group, n= 82). According to thyroid functions, the HT group was further divided into an NHT group (normal thyroid function, n= 39) and an SHT group (hypothyroidism or subclinical hypothyroidism, n=43). A total of 51 patients (NC group) who visited the hospital for consultation during the same period were designated as the control group. Peripheral venous blood plasma was collected. BAFF and IL-21 were tested via enzyme-linked immunosorbent assay(ELISA). Thyroid function, thyroid microsomal antibody (TMAB) and thyroglobulin antibody (TGAB) were detected via chemiluminescence immunoassay. Data were analysed using SPSS 24.0.  Results  The levels of BAFF and IL-21 in the plasma of the HT group were significantly higher than those of the NC group (all P < 0.05). The levels of BAFF in the SHT group was significantly higher than that in the NHT group (P < 0.05). The plasma levels of BAFF in the patients with HT were positively correlated with TGAB and TMAB (r=0.444 and 0.401, respectively; all P < 0.05). Similarly, IL-21 was positively correlated with TGAB and TMAB (r=0.451 and 0.451, respectively; all P < 0.05). A positive correlation was observed between BAFF and IL-21 (r=0.324, P < 0.05). By contrast, a negative correlation was found between BAFF and total T4(TT4, r=-0.214, P < 0.05). The combined diagnosis of HT with BAFF and IL-21 (AUC=0.896) was more valuable than that of BAFF (AUC=0.862) and IL-21 (AUC=0.809) alone.  Conclusion  BAFF combined with IL-21 has a certain value in the diagnosis of HT. BAFF and IL-21 play an important role in the occurrence and development of HT. Moreover, they participate in the maturation, proliferation and differentiation of B cells. Finally, they participate jointly in the production of TGAB and TMAR.

     

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