Volume 19 Issue 4
Apr.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(4): 586-588, 688
GU Tian-yi, YANG Qi-guo, JIN Bo. Expression of serum SUR1 in middle-aged and elderly patients with aneurysmal subarachnoid hemorrhage and its relationship with prognosis[J]. Chinese Journal of General Practice, 2021, 19(4): 586-588, 688. doi: 10.16766/j.cnki.issn.1674-4152.001867
Citation: GU Tian-yi, YANG Qi-guo, JIN Bo. Expression of serum SUR1 in middle-aged and elderly patients with aneurysmal subarachnoid hemorrhage and its relationship with prognosis[J]. Chinese Journal of General Practice, 2021, 19(4): 586-588, 688. doi: 10.16766/j.cnki.issn.1674-4152.001867
shu

Expression of serum SUR1 in middle-aged and elderly patients with aneurysmal subarachnoid hemorrhage and its relationship with prognosis

doi: 10.16766/j.cnki.issn.1674-4152.001867

  • Department of Neurosurgery, Ningbo Sixth Hospital, Ningbo, Zhejiang 315000, China

Funds:

 2017KY148

  • Received Date: 2020-01-13
    Available Online: 2022-02-16
    Abstract
  •   Objective  To investigate the expression and correlation of serum sulfonylurea receptor 1 (SUR1) in middle-aged and elderly patients with aneurysmal subarachnoid haemorrhage (aSAH).  Methods  Ninety-one patients suffering from aSAH admitted to Ningbo Sixth Hospital from July 2015 to May 2019 were selected as the observation objects. The expression of SUR1 in serum before operation was detected via fluorescence real-time quantitative polymerase chain reaction. According to the median expression of Sulfonylurea receptor 1(SUR1) in serum before operation, the patients were divided into low SUR1 expression group (n=46) and high SUR1 expression group (n=45). Before operation, the degree of nerve defect in the patients with aSAH was evaluated using the national institutes of health stroke scale (NIHSS) score. At 6 months after operation, prognosis was assessed using the Glasgow Outcome Scale, and the patients were divided into good prognosis group (n=77) and poor prognosis group (n=14). The expression of SUR1 before operation was compared between the two groups. The correlation between SUR1 expression and NIHSS score was evaluated via Spearman correlation analysis. The prognostic factors of the patients with aSAH were analysed via Cox model.  Results  The proportion of patients with hypertension history, with diabetes history, preoperative NIHSS score and operative timing in the good prognosis group were lower than those in the poor prognosis group (all P < 0.05). The expression of serum SUR1 in patients with aSAH in the poor prognosis group was higher than that in the good prognosis group (P < 0.05). Spearman correlation analysis revealed a positive correlation between serum SUR1 expression and NIHSS score in the patients with aSAH (P < 0.05). The Results of Cox regression model showed that age of >60 years, history of hypertension, history of diabetes, NIHSS score ≥15, 3-7 d of operation timing and SUR1 overexpression were all independent risk factors for the prognosis of patients with aSAH (all P < 0.05).  Conclusion  SUR1 may be involved in the development and progression of aSAH in the middle-aged and the elderly, and may become a serological index for the assessment of aSAH and treatment target.

     

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