Volume 19 Issue 4
Apr.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(4): 596-598
WANG Yue, CHEN Xin. Clinical research of 30 premature infants with lowhypotriiodothyronine syndrome[J]. Chinese Journal of General Practice, 2021, 19(4): 596-598. doi: 10.16766/j.cnki.issn.1674-4152.001870
Citation: WANG Yue, CHEN Xin. Clinical research of 30 premature infants with lowhypotriiodothyronine syndrome[J]. Chinese Journal of General Practice, 2021, 19(4): 596-598. doi: 10.16766/j.cnki.issn.1674-4152.001870
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Clinical research of 30 premature infants with lowhypotriiodothyronine syndrome

doi: 10.16766/j.cnki.issn.1674-4152.001870

  • Department of Paediatrics, the First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China

Funds:

 KJ2019A0378

  • Received Date: 2020-07-27
    Available Online: 2022-02-16
    Abstract
  •   Objective  To observe the adverse effects of low hypotriiodothyronine (T3) syndrome on premature infants.  Methods  Thirty premature infants hospitalised in the neonatal ward of The First Affiliated Hospital of Bengbu Medical College from January to 2019 to December 2019 were selected. About 4 to 7 days and 4 weeks after birth, 2 mL of fasting venous blood was collected from the infants. Serum thyroid-stimulating hormone (TSH), free triiodothyronine (FT3) and triiodothyronine (T3) were determined via electrochemiluminescence. According to the diagnostic criteria, premature infants diagnosed with low T3 were taken as the observation group (n=30), whereas premature infants with normal thyroid functions at the same gestational age were taken as the control group (n=30). No statistical difference was observed in the general conditions of the two groups (P > 0.05), both group were given with the same basic supportive treatment. Differences in the duration of jaundice, feeding intolerance, hospitalisation days, days of birth weight recovery and neonatal behavior neurological assessment (NBNA)test scores at 40 weeks of gestational age were observed between the two groups.  Results  Between the two groups, T3 levels at 4 to 7 days after birth (t=-19.042, P < 0.001) and FT3 levels at 4 weeks after birth (t=-22.041, P < 0.001) were statistically significant. At 4 weeks after birth, T3 levels (t=-1.933, P=0.059) and FT3 levels (t=-1.622, P=0.110) were not statistically significant. The differences in jaundice duration (t=2.759, P=0.008), feeding intolerance (χ2=8.531, P=0.003), hospitalisation days (t=6.471, P < 0.001) and birth weight recovery days (t=6.584, P < 0.001) were statistically significant between the two groups. However, no statistically significant difference (t=-1.842, P=0.071) was observed in NBNA scores between the two groups at the correct gestational age of 40 weeks.  Conclusion  Children with a low T3 syndrome have longer jaundice durations, hospitalisation days and weight recovery times, as well as a higher incidence of feeding intolerance, than children with normal thyroid functions. Nevertheless, their short-term neurodevelopment was not significantly influenced.

     

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