Volume 19 Issue 5
May  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(5): 794-797
FAN Jun-fang, HU Jing, GENG Xu, ZHUANG Lan-gen, SHI Zhao-ming. Correlation between liver-controlled attenuation parameters and serum 25-hydroxyvitamin D level in patients with type 2 diabetes[J]. Chinese Journal of General Practice, 2021, 19(5): 794-797. doi: 10.16766/j.cnki.issn.1674-4152.001919
Citation: FAN Jun-fang, HU Jing, GENG Xu, ZHUANG Lan-gen, SHI Zhao-ming. Correlation between liver-controlled attenuation parameters and serum 25-hydroxyvitamin D level in patients with type 2 diabetes[J]. Chinese Journal of General Practice, 2021, 19(5): 794-797. doi: 10.16766/j.cnki.issn.1674-4152.001919
shu

Correlation between liver-controlled attenuation parameters and serum 25-hydroxyvitamin D level in patients with type 2 diabetes

doi: 10.16766/j.cnki.issn.1674-4152.001919
  • 1.

    Department of Endocrinology, the First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China

Funds:

 202010367016

  • Received Date: 2020-12-25
    Available Online: 2022-02-16
    Abstract
  •   Objective  This study aimed to investigate the correlation between controlled attenuation parameters (CAP) of the liver and serum 25-hydroxyvitamin D[25(OH)D] in patients with type 2 diabetes mellitus (T2DM).  Methods  A total of 160 patients with T2DM who were admitted to the First Affiliated Hospital of Bengbu Medical College from May 2019 to July 2020 were selected. On the basis of the CAP value, the patients were divided into the following groups: without NAFLD (43 patients), with mild NAFLD (35 patients), with moderate NAFLD (35 patients) and with severe NAFLD (47 patients). Vat, SAT, 25(OH)D and other biochemical indexes were measured, and differences in biochemical indexes amongst the groups were compared. Logistic regression analysis and Pearson or Spearman correlation analysis were performed, and ROC curve was used to analyse the optimal threshold of CAP for predicting vitamin D deficiency in patients with T2DM.  Results  25(OH)D in the non-NAFLD group was significantly higher than that in the moderate and severe NAFLD groups, and 25(OH)D in the mild and moderate NAFLD groups was significantly higher than that in the severe NAFLD group (all P < 0.05). CAP was negatively correlated with 25(OH)D and HDL-C (r=-0.436, -0.193, all P < 0.05), whereas CAP was positively correlated with WHR, BMI, VAT, SAT, TC, TG, FINS, HOMA-IR, FFA, CRP, γ-GT and ALT (r= 0.276-0.447, all P < 0.05). 25(OH)D was negatively correlated with CAP, VAT, FBG, TC, TG, FFA, HOMA-IR, ALT, CRP and γ-GT (r=-0.436--0.156, all P < 0.05). Logistic regression analysis showed that FFA and 25(OH)D were the influencing factors for the development of NAFLD in T2DM. ROC curve showed that CAP265 dB/m as the diagnostic threshold had a sensitivity of 0.776 and a specificity of 0.637 for predicting vitamin D deficiency.  Conclusion  Liver fat content is negatively correlated with serum 25(OH)D in patients with T2DM, and 25(OH)D is a protective factor for NAFLD in T2DM.

     

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    • References(15)
  • [1]
    洪文忠, 李奕萍. 血清γ-GT、CHE、Apelin及内脂素水平在非酒精性脂肪肝病患者中的诊疗价值[J]. 中华全科医学, 2020, 18(3): 463-466. https://www.cnki.com.cn/Article/CJFDTOTAL-SYQY202003034.htm
    [2]
    LALLUKKA S, YKI-JÄRVINEN H. Non-alcoholic fatty liver disease and risk of type 2 diabetes[J]. Best Pract Res Clin Endocrinol Metab, 2016, 30(3): 385-395. doi: 10.1016/j.beem.2016.06.006
    [3]
    SAPONARO C, GAGGINI M, GASTALDELLI A. Nonalcoholic fatty liver disease and type 2 diabetes: common pathophysiologic mechanisms[J]. Current Diabetes Reports, 2015, 15(6): 1-13. doi: 10.1007%2Fs11892-015-0607-4.pdf
    [4]
    DING Y H, WEI T M, QIAN L Y, et al. Association between serum 25-hydroxyvitamin D and carotid atherosclerotic plaque in Chinese type 2 diabetic patients[J]. Medicine, 2017, 96(13): 6445. doi: 10.1097/MD.0000000000006445
    [5]
    董智慧. 老年2型糖尿病患者25羟维生素D与糖脂代谢、颈动脉内膜中层厚度的关系[J]. 中国老年学杂志, 2020, 40(9): 1820-1823. doi: 10.3969/j.issn.1005-9202.2020.09.010
    [6]
    ALHEWISHEL MA, BAHGAT M, AL HUWAIYSHIL A, et al. 25(OH)D serum level in non-diabetic and type Ⅱ diabetic patients: a cross-sectional study[J]. Cureus, 2020, 12(6): e8910. http://www.researchgate.net/publication/342545548_25OHD_Serum_Level_in_Non-Diabetic_and_Type_II_Diabetic_Patients_A_Cross-Sectional_Study/download
    [7]
    李静波, 刘姝, 温博, 等. FibroTouch与B超、CT对脂肪肝的诊断价值比较[J]. 临床肝胆病杂志, 2016, 32(3): 459-462. doi: 10.3969/j.issn.1001-5256.2016.03.011
    [8]
    KIM J, LEE H, LIM J, et al. The angiogenesis inhibitor ALS-L1023 from lemon-balm leaves attenuates high-fat diet-induced nonalcoholic fatty liver disease through regulating the visceral adipose-tissue function[J]. Int J Mol Sci, 2017, 18(4): 846-881. doi: 10.3390/ijms18040846
    [9]
    KO Y H, WONG T C, HSU Y Y, et al. The correlation between body fat, visceral fat, and nonalcoholic fatty liver disease[J]. Metab Syndr Relat Disord, 2017, 15(6): 304-311. doi: 10.1089/met.2017.0001
    [10]
    KWOK R, CHOI K C, WONG G L, et al. Screening diabetic patients for non-alcoholic fatty liver disease with controlled attenuation parameter and liver stiffness measurements: a prospective cohort study[J]. Gut, 2016, 65(8): 1359-1368. doi: 10.1136/gutjnl-2015-309265
    [11]
    杨丽弘, 廖鑫, 张晗, 等. 2型糖尿病合并非酒精性脂肪肝肝纤维化与血清25-羟维生素D水平的关系研究[J]. 中国糖尿病杂志, 2018, 26(2): 117-122. doi: 10.3969/j.issn.1006-6187.2018.02.007
    [12]
    齐潇雁, 肖新华. 非酒精性脂肪肝与2型糖尿病研究进展[J]. 中国现代医药杂志, 2015, 17(12): 89-92. doi: 10.3969/j.issn.1672-9463.2015.12.032
    [13]
    SILVAGNO F, PESCARMONA G. Spotlight on vitamin D receptor, lipid metabolism and mitochondria: Some preliminary emerging issues[J]. Mol Cell Endocrinol, 2017, 450: 24-31. doi: 10.1016/j.mce.2017.04.013
    [14]
    BORGES C C, SALLES A F, BRINGHENTI I, et al. Vitamin D deficiency increases lipogenesis and reduces beta-oxidation in the liver of diet-induced obese mice[J]. J Nutr Sci Vitaminol (Tokyo), 2018, 64(2): 106-115. doi: 10.3177/jnsv.64.106
    [15]
    马世瞻, 赵家军. 内分泌与脂代谢[J]. 华西医学, 2018, 33(5): 491-498. https://www.cnki.com.cn/Article/CJFDTOTAL-HXYX201805001.htm
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