Volume 19 Issue 5
May  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(5): 805-808
ZHAO Bing, DING Zhou-zhi, CHEN Xin. Expression and significance of serum NSE and S100B protein during different degrees of neonatal asphyxia[J]. Chinese Journal of General Practice, 2021, 19(5): 805-808. doi: 10.16766/j.cnki.issn.1674-4152.001922
Citation: ZHAO Bing, DING Zhou-zhi, CHEN Xin. Expression and significance of serum NSE and S100B protein during different degrees of neonatal asphyxia[J]. Chinese Journal of General Practice, 2021, 19(5): 805-808. doi: 10.16766/j.cnki.issn.1674-4152.001922
shu

Expression and significance of serum NSE and S100B protein during different degrees of neonatal asphyxia

doi: 10.16766/j.cnki.issn.1674-4152.001922

  • Neonatal Intensive Care Unit, the First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China

Funds:

 KJ2019A0378

  • Received Date: 2020-06-08
    Available Online: 2022-02-16
    Abstract
  •   Objective  Neonatal asphyxia is a common disease during the neonatal period. Early and correct diagnosis of this disease is very important for treatment. This study investigated the expression of neuron-specific enolase (NSE) and central nervous system-specific protein B (S100B protein) in the serum of newborns with different degrees of asphyxia. This study examined whether these proteins can be used as indicators in the diagnosis of neonatal asphyxia.  Methods  Seventy newborns admitted to the NICU of the First Affiliated Hospital of Bengbu Medical College from December 2018 to April 2020 were selected and assigned to the asphyxia group. Then according to the Apgar(appearance, pulse, grimace, activity, and respiration) score at birth, the they were again divided into mild asphyxia group (n=40) and severe asphyxia group (n=30). 40 healthy newborns were selected as the normal control group, during the same period. The Levels of serum NSE and S100B were measured within 24 h after birth in each group and 7 days after treatment in the asphyxia group.  Results  The levels of serum NSE and S100B in the mild asphyxia and severe asphyxia groups were significantly higher than those in the control group. The levels of serum NSE and S100B in the severe asphyxia group were significantly higher than those in the mild asphyxia group (all P < 0.05). After the treatment, the levels of serum NSE and S100B in the mild asphyxia and severe asphyxia groups significantly decreased (all P < 0.05). The sensitivity and specificity of serum NSE to the prediction of neonatal asphyxia were 81.43% and 97.50%, respectively. The area under the receiver operating characteristic curve (AUC) was 0.939. By comparison, the sensitivity and specificity of serum S100B to the prediction of neonatal asphyxia were 80.00% and 100.00%, respectively. The AUC curve was 0.916.  Conclusion  Both serum NSE and S100B can be used as an important basis for the diagnosis of neonatal asphyxia and have a certain reference value for clinical evaluation of the degree of neonatal asphyxia.

     

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