Dynamic changes and significance of serum NSE and S100B protein in patients with craniocerebral injury

LIANG Jiong-fang; GAO Feng-ping; LIU Ke-hong

doi:10.16766/j.cnki.issn.1674-4152.001930

Volume 19 Issue 5

May 2021

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Article Navigation > Chinese Journal of General Practice > 2021 > 19(5): 838-840, 850

LIANG Jiong-fang, GAO Feng-ping, LIU Ke-hong. Dynamic changes and significance of serum NSE and S100B protein in patients with craniocerebral injury[J]. Chinese Journal of General Practice, 2021, 19(5): 838-840, 850. doi: 10.16766/j.cnki.issn.1674-4152.001930

Citation:

LIANG Jiong-fang, GAO Feng-ping, LIU Ke-hong. Dynamic changes and significance of serum NSE and S100B protein in patients with craniocerebral injury[J]. Chinese Journal of General Practice, 2021, 19(5): 838-840, 850. doi: 10.16766/j.cnki.issn.1674-4152.001930

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Dynamic changes and significance of serum NSE and S100B protein in patients with craniocerebral injury

doi: 10.16766/j.cnki.issn.1674-4152.001930

1.
Department of Clinical Laboratory of Zhejiang General Hospital of Armed Police, Hangzhou, Zhejiang 310000, China

Funds:

2020KY776

Received Date: 2020-05-22
Available Online: 2022-02-16

Abstract

Abstract

Objective To explore the dynamic changes and clinical significance of serum NSE and S100B protein levels after craniocerebral injury. Methods A total of 105 patients with craniocerebral injury received by the Emergency Department of Zhejiang General Hospital of Armed Police from January 2018 to December 2019 were selected as the study objects. According to Glasgow's score, they were divided into mild group (n=30), moderate group (n=45) and severe group (n=30). Another 30 healthy people in the same period were selected as the control group. Dynamic monitoring and statistical analysis of serum NSE and S100B protein data after head injury were conducted. Results The serum NSE and S100B protein levels among the four groups were (34.51±5.39) μg/L, (19.31±2.72) μg/L, (13.68±3.02) μg/L, (6.11±2.35) μg/L and (2.29±0.28) μg/L, (1.47±0.15) μg/L, (0.81±0.18) μg/L, (0.32±0.09) μg/L (F=357.010, 653.126, all P < 0.001)respectively. For each group at the same time, the difference in serum NSE and S100B protein was statistically significant (all P < 0.05). The differences in serum NSE and S100B between groups within the group and at different time points were statistically significant (all P < 0.05). Conclusion Serum NSE and S100B protein levels can dynamically reflect the progress of acute craniocerebral injury a which have important clinical guiding significance for the revision of the disease disease classification, formulation of treatment plans assessment of prognosis.
- Craniocerebral injury,
- Neuron-specific enolase,
- S100B protein,
- Dynamic Monitoring

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Dynamic changes and significance of serum NSE and S100B protein in patients with craniocerebral injury

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