Progress in early diagnosis of congenital biliary atresia

CHEN Xue-zhong; GUAN Yan-xing; ZHAN Chun-lei

doi:10.16766/j.cnki.issn.1674-4152.001932

Volume 19 Issue 5

May 2021

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Article Navigation > Chinese Journal of General Practice > 2021 > 19(5): 846-850

CHEN Xue-zhong, GUAN Yan-xing, ZHAN Chun-lei. Progress in early diagnosis of congenital biliary atresia[J]. Chinese Journal of General Practice, 2021, 19(5): 846-850. doi: 10.16766/j.cnki.issn.1674-4152.001932

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CHEN Xue-zhong, GUAN Yan-xing, ZHAN Chun-lei. Progress in early diagnosis of congenital biliary atresia[J]. Chinese Journal of General Practice, 2021, 19(5): 846-850. doi: 10.16766/j.cnki.issn.1674-4152.001932

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Progress in early diagnosis of congenital biliary atresia

doi: 10.16766/j.cnki.issn.1674-4152.001932

1.
Department of Nuclear Medicine, the First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China

Funds:

20195561

20122BBG70132

700110002

Received Date: 2020-01-03
Available Online: 2022-02-16

Abstract

Abstract

Congenital biliary atresia is the most common cause of neonatal cholestasis and is the main indicator of paediatric liver transplantation. If not treated promptly, it can lead to progressive liver fibrosis, cholestasis cirrhosis and even death. Timely Kasai surgery or liver transplantation can significantly improve the prognosis of children with congenital biliary atresia, so early differential diagnosis is extremely important. However, congenital biliary atresia and other causes of neonatal cholestasis have many common points in clinical manifestations, laboratory tests and imaging features, which brings great difficulties to clinical differential diagnosis. In the past decade, various non-invasive diagnosis approach for congenital biliary atresia has made great progress, including the development of early screening, features of biomarkers, improved inspection of qualitative and quantitative indicators of ultrasound, and the applications of radionuclide hepatobiliary dynamic imaging, endoscopic retrograde cholangiopancreatography (ERCP) and magnetic resonance cholangiopancreatography (MRCP). Currently though, no clinically non-invasive method is available for the differential diagnosis of congenital biliary atresia with high sensitivity and specificity. Intraoperative biliary exploration and angiography remain the most accurate methods for diagnosing congenital biliary atresia, but the invasiveness of the method and the high requirements for the surgeon limit its clinical application. Based on the characteristics of early clinical early differential diagnosis of congenital biliary atresia, this review further explores the best strategy for early diagnosis and diagnosis of congenital biliary atresia by multidisciplinary and multi-technical combination to improve the early differential diagnosis of congenital biliary atresia. This review provides reference for promoting the sensitivity and specificity of the early differential diagnosis of congenital biliary atresia.
- Congenital biliary atresia,
- Early differential diagnosis,
- Non-invasive diagnosis method,
- Hepatobiliary scintigraphy,
- Ultrasonographic

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References(39)

References

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Progress in early diagnosis of congenital biliary atresia

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