Volume 19 Issue 5
May  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(5): 851-855
SHENG Yu-qin, YANG Wen-ming, ZHANG Juan. Clinical study of the effects of moxibustion combined with Gandou Decoction on improving early hypersplenism in Wilson disease[J]. Chinese Journal of General Practice, 2021, 19(5): 851-855. doi: 10.16766/j.cnki.issn.1674-4152.001933
Citation: SHENG Yu-qin, YANG Wen-ming, ZHANG Juan. Clinical study of the effects of moxibustion combined with Gandou Decoction on improving early hypersplenism in Wilson disease[J]. Chinese Journal of General Practice, 2021, 19(5): 851-855. doi: 10.16766/j.cnki.issn.1674-4152.001933
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Clinical study of the effects of moxibustion combined with Gandou Decoction on improving early hypersplenism in Wilson disease

doi: 10.16766/j.cnki.issn.1674-4152.001933

  • Department of Encephalitis Disease, the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Hefei, Anhui 230031, China

Funds:

 81774299

  • Received Date: 2020-06-29
    Available Online: 2022-02-16
    Abstract
  •   Objective  To explore the clinical effects of moxibustion combined with Gandou Decoction on improving the early hypersplenism of patients with Wilson disease (WD).   Methods  Sixty patients with WD and early hypersplenism were selected from October 2016 to May 2020. They were randomly divided into a control group and an observation group, with 30 cases in each group. The patients in both groups were administered with sodium dimercaptopropionic acid injection once a day for six times a week). The patients in the observation group were treated with additional moxibustion and Gandou Decoction, a course of treatment that lasted for 8 days. Both groups were treated for 2 weeks. The Clinical efficacy and changes in WBC, RBC, PLT, Hb and liver function index(ALT, AST, Alb and Alb levels) were observed after two courses of treatment.   Results  The clinical efficacy in the observation group (90.0%) was significantly better than that in the control group (63.3%, χ2=5.963, P=0.015). The levels of WBC, RBC, PLT and Hb in the first and second courses of treatment in both groups were significantly different from those before treatment (all P < 0.01). No significant difference was observed in WBC, RBC, PLT and Hb levels before treatment and after the first course of treatment in the observation group compared with those in the control group (all P>0.05), and these indicators in the observation group after the second course of treatment were significantly higher than those in the control group (all P < 0.05). The levels of ALT, AST and Alb in each course of treatment in both groups were significantly different from those before treatment (all P < 0.01). Compared with those in the control group, no significant difference was found in the levels of ALT, AST, Alb and Alb in the observation group after the first course of treatment (all P>0.05). After the first and second courses of treatment, the levels of ALT and AST in the observation group were lower than those in the control group (all P < 0.05). Moreover, the level of Alb level in the observation group after the second course of treatment was significantly higher than that in the control group (P < 0.01).   Conclusion  Moxibustion combined with Gandou Decoction can improve the clinical symptoms of WD patients with early hypersplenism.

     

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    • References(27)
  • [1]
    杨任民. 肝豆状核变性[M]. 北京: 人民卫生出版社, 2015: 21-22.
    [2]
    CHENG N, WANG K, HU W B, et al. Wilson's disease in the south Chinese Han population[J]. Can J Neurol Sci, 2014, 41(3): 363-367. doi: 10.1017/S0317167100017315
    [3]
    董文文, 杨文明, 董婷, 等. 应用注意网络测试研究肝豆状核变性患者注意损害[J]. 中华全科医学, 2019, 17(12): 1998-2000. https://www.cnki.com.cn/Article/CJFDTOTAL-SYQY201912006.htm
    [4]
    蒋雨平, 王坚, 蒋雯魏. 新编神经疾病学[M]. 上海: 上海科学普及出版社, 2014: 363-365.
    [5]
    梁启新, 徐余兴, 郭旗. 手术治疗肝豆状核变性并脾功能亢进的疗效评价[J]. 安徽医药, 2015, 19(1): 104-106. doi: 10.3969/j.issn.1009-6469.2015.01.029
    [6]
    鲍远程. 现代中医神经病学[M]. 北京: 人民卫生出版社, 2003: 523-527.
    [7]
    胡纪源, 周志华, 韩咏竹, 等. 肝豆状核变性患者中医证型与血尿酸、Goldstein分级的关系[J]. 中国中西医结合杂志, 2015, 35(11): 1335-1339. doi: 10.7661/CJIM.2015.11.1335
    [8]
    徐磊, 蔡永亮, 蒋怀周, 等. 肝豆灵片治疗肝豆状核变性痰瘀互结证的疗效观察[J]. 中国实验方剂学杂志, 2017, 23(15): 173-175. https://www.cnki.com.cn/Article/CJFDTOTAL-ZSFX201715030.htm
    [9]
    韩辉, 杨文明, 张娟, 等. 肝豆状核变性的中医证候特征[J]. 中医药临床杂志, 2014, 26(1): 16-19. https://www.cnki.com.cn/Article/CJFDTOTAL-AHLC201401008.htm
    [10]
    于露, 王艳昕. 肝豆状核变性的中医治疗进展[J]. 光明中医, 2017, 32(14): 2134-2136. doi: 10.3969/j.issn.1003-8914.2017.14.069
    [11]
    沈斌, 鲍远程. 鲍远程辩证治疗肝风经验[J]. 河南中医, 2017, 37(2): 227-229.
    [12]
    程楠, 韩咏竹, 杨任民. 中药肝豆汤治疗Wilson病疗效机制的研究进展[J]. 中国实验方剂学杂志, 2019, 25(7): 49-53. https://www.cnki.com.cn/Article/CJFDTOTAL-ZSFX201907043.htm
    [13]
    汪美霞, 詹宇婷, 董婷, 等. 肝豆汤加减治疗湿热内蕴型肝豆状核变性的临床疗效研究[J]. 中国全科医学, 2017, 20(28): 3573-3577. https://www.cnki.com.cn/Article/CJFDTOTAL-QKYX201728029.htm
    [14]
    原佩玉, 郝重耀, 张天生. 艾灸效应的原理及功能的临床研究现状[J]. 中国医药导报, 2019, 16(12): 31-34. https://www.cnki.com.cn/Article/CJFDTOTAL-YYCY201912008.htm
    [15]
    吴焕淦, 翁志军, 刘慧荣, 等. 基于免疫相关性疾病的艾灸镇痛与抗炎免疫研究[J]. 世界中医药, 2016, 11(12): 2505-2512. https://www.cnki.com.cn/Article/CJFDTOTAL-SJZA201612001.htm
    [16]
    詹振吉, 王健. 艾灸对机体免疫系统的影响[J]. 中医学报, 2016, 31(3): 449-452. https://www.cnki.com.cn/Article/CJFDTOTAL-HNZK201603044.htm
    [17]
    黄畅, 蒋洁, 刘钧天, 等. 艾灸及艾烟对化疗所致白细胞减少症模型小鼠的影响[J]. 中华中医药杂志, 2016, 31(8): 3220-3223. https://www.cnki.com.cn/Article/CJFDTOTAL-BXYY201608092.htm
    [18]
    陈丽芳, 关次易, 张伟兰, 等. 艾灸大椎、足三里穴穴位防治乳腺癌化疗术后白细胞减少证的临床研究[J]. 内蒙古中医药, 2017, 5(2): 72-73.
    [19]
    张介宾. 类经图翼[M]. 上海: 人民出版社, 2005: 413.
    [20]
    贾政敏, 黄碧纯. 艾灸关元穴防治疾病的研究进展[J]. 国医论坛, 2015, 30(3): 66-68. https://www.cnki.com.cn/Article/CJFDTOTAL-GYLT201503043.htm
    [21]
    寇任重, 邹洋洋, 张建斌. 艾灸关元穴生物学效应及其影响因素的探讨[J]. 中国针灸, 2016, 36(12): 1273-1275. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGZE201612017.htm
    [22]
    姚春鹏. 中华经典藏书: 黄帝内经[M]. 北京: 中华书局, 2010: 292.
    [23]
    严越台, 沈丹, 阮婴丹, 等. 艾灸关元、气海穴对晚期肝癌患者生存质量影响的临床观察[J]. 中华全科医学, 2017, 15(7): 1227-1229. https://www.cnki.com.cn/Article/CJFDTOTAL-SYQY201707042.htm
    [24]
    代田文志. 针灸真髓[M]. 南京: 江苏人民出版社, 1958: 149.
    [25]
    容贤冰, 邓武装, 蒋晓明, 等. 艾灸足三里穴与关元穴对训练小鼠免疫功能的影响[J]. 重庆医学, 2014, 43(17): 2161-2163. https://www.cnki.com.cn/Article/CJFDTOTAL-CQYX201417019.htm
    [26]
    张静, 方媛, 崔圣伟, 等. 肝豆汤联合二巯基丙磺酸钠对湿热内蕴型肝豆状核变性患者的影响[J]. 中国实验方剂学杂志, 2017, 23(17): 190-194. https://www.cnki.com.cn/Article/CJFDTOTAL-ZSFX201717033.htm
    [27]
    李响, 蔡洁, 徐钰雯, 等. 肝豆状核变性合并肝细胞癌1例报告[J]. 临床肝胆病杂志, 2018, 34(9): 1967-1971. https://www.cnki.com.cn/Article/CJFDTOTAL-LCGD201809027.htm
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