Volume 19 Issue 6
Jun.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(6): 901-903
ZOU Chun-yu, YUE Chen, YANG Lan-bo, MI Yu-fei, WANG Zhan-chao. Safety and effectiveness of tranexamic acid in patients combined with high risk comorbidities for postoperative venous thromboembolism during total knee arthroplasty[J]. Chinese Journal of General Practice, 2021, 19(6): 901-903. doi: 10.16766/j.cnki.issn.1674-4152.001945
Citation: ZOU Chun-yu, YUE Chen, YANG Lan-bo, MI Yu-fei, WANG Zhan-chao. Safety and effectiveness of tranexamic acid in patients combined with high risk comorbidities for postoperative venous thromboembolism during total knee arthroplasty[J]. Chinese Journal of General Practice, 2021, 19(6): 901-903. doi: 10.16766/j.cnki.issn.1674-4152.001945
shu

Safety and effectiveness of tranexamic acid in patients combined with high risk comorbidities for postoperative venous thromboembolism during total knee arthroplasty

doi: 10.16766/j.cnki.issn.1674-4152.001945

  • Treatment Center of the Knee, Luoyang Orthopedic Hospital of Henan Province. Orthopedic Hospital of Henan Province, Luoyang, Henan 471000, China

Funds:

 81804126

  • Received Date: 2020-07-06
    Available Online: 2022-02-16
    Abstract
  •   Objective  To assess the safety and efficacy of tranexamic acid (TXA) in patients with high risk comorbidities for venous thromboembolic events (VTE) during total knee arthroplasty (TKA).  Methods  We chose eight risk factors for postoperative VTE during TKA. Patients in Luoyang Orthopedic Hospital of Henan Province were reviewed from January 2010 to December 2019 and were divided into control, intravenous TXA, and topical TXA group. The safety outcomes were identified as the incidence of VTE, and the efficacy outcome was limited to transfusions.  Results  Through a comprehensive review of 7 836 consecutive TKA cases from 2010 to 2019, 781 cases were included according to the inclusion criteria. Of them, 341 cases didn't receive TXA, 163 patients received intravenous TXA and 277 patients received topical TXA. The incidence of VTE was not significant difference across these three groups (8.50% vs. 9.82% vs. 7.94%), and the transfusion rate was significantly lower in the intravenous and topical TXA groups than the control group (31.67% vs. 18.40% vs. 22.38%, P=0.002).  Conclusion  This study preliminary showed that TXA was effective to decrease transfusions without sacrificing the safety in patients with high risk comorbidities for VTE during TKA.

     

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