Application effect of <i>Angong Niuhuang</i> Pills in patients with cardiac arrest after cardiopulmonary resuscitation

LYU Xin; ZHANG Ying; TANG Wen-xue

doi:10.16766/j.cnki.issn.1674-4152.001951

Volume 19 Issue 6

Jun. 2021

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Article Navigation > Chinese Journal of General Practice > 2021 > 19(6): 925-928,1038

LYU Xin, ZHANG Ying, TANG Wen-xue. Application effect of Angong Niuhuang Pills in patients with cardiac arrest after cardiopulmonary resuscitation[J]. Chinese Journal of General Practice, 2021, 19(6): 925-928,1038. doi: 10.16766/j.cnki.issn.1674-4152.001951

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LYU Xin, ZHANG Ying, TANG Wen-xue. Application effect of Angong Niuhuang Pills in patients with cardiac arrest after cardiopulmonary resuscitation[J]. Chinese Journal of General Practice, 2021, 19(6): 925-928,1038. doi: 10.16766/j.cnki.issn.1674-4152.001951

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Application effect of Angong Niuhuang Pills in patients with cardiac arrest after cardiopulmonary resuscitation

doi: 10.16766/j.cnki.issn.1674-4152.001951

Intensive Care Unit, Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang 310015, China

Funds:

2016ZB103

2018ZB101

Received Date: 2020-05-28
Available Online: 2022-02-16

Abstract

Abstract

Objective To observe the application value of Angong Niuhuang Pills in patients with emergency cardiac arrest (CA) after cardiopulmonary resuscitation (CPR). Methods Total 90 patients with CA and return of spontaneous circulation (CA-ROSC) who were admitted to the General Intensive Care Unit (GICU) of Affiliated Hospital of Hangzhou Normal University from August 2017 to June 2019 were equally divided into observation groups (n=45) and the control group (n=45) by random number table method. The control group was treated with intravenous drip of naloxone immediately after ROSC, while the observation group was treated with Angong Niuhuang Pills based on the treatment of control group. Both groups were treated for 1 week. The cerebral metabolic rate for oxygen (CMRO₂), oxidative stress injury, serum S100β and matrix metalloproteinase-9 (MMP-9) levels and prognosis were compared between the 2 groups. Results At 3 d and 7 d after treatment, CMRO₂ of the observation group was significantly higher than that of the control group (P < 0.05). After treatment, superoxide dismutase [(96.45±9.47) U/mL] and glutathione peroxidase [(82.58±11.49) U/L] of observation group were significantly higher, while malondialdehyde [(9.52±1.88) nmol/mL] was significantly lower, compared with those of the control group [(84.25±8.87) U/mL, (73.60±10.75) U/L, (11.03±3.06) nmol/mL, all P < 0.05]. After treatment, S100β and MMP-9 were significantly lower in the observation group than those in the control group. The proportion of successful cerebral resuscitation in the observation group was significantly higher than that in the control group, and successful cerebral resuscitation time was significantly shorter than the control group. After treatment, the Glasgow Coma Scale (GCS) scores of observation group were significantly higher but the Glasgow-Pittsburgh cerebral performance categories (CPC) scores were significantly lower, compared with the control group (all P < 0.05). Conclusion Angong Niuhuang Pills can effectively improve cerebral oxygen metabolism and reduce oxidative stress injury and brain injury in patients with CA after CPR, which is conductive to the prognosis.
- Angong Niuhuang Pills,
- Emergency cardiac arrest,
- Cerebral metabolic rate for oxygen,
- Oxidative stress injury,
- Serum S100β,
- Matrix metalloproteinase-9

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References

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Application effect of Angong Niuhuang Pills in patients with cardiac arrest after cardiopulmonary resuscitation

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