Volume 19 Issue 6
Jun.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(6): 979-981, 1007
WANG Cheng-cheng, LIU Huai-lei, GONG Wei-hong. Association of blood cell parameters with non-alcoholic fatty liver disease in the elderly with hypertension[J]. Chinese Journal of General Practice, 2021, 19(6): 979-981, 1007. doi: 10.16766/j.cnki.issn.1674-4152.001965
Citation: WANG Cheng-cheng, LIU Huai-lei, GONG Wei-hong. Association of blood cell parameters with non-alcoholic fatty liver disease in the elderly with hypertension[J]. Chinese Journal of General Practice, 2021, 19(6): 979-981, 1007. doi: 10.16766/j.cnki.issn.1674-4152.001965
shu

Association of blood cell parameters with non-alcoholic fatty liver disease in the elderly with hypertension

doi: 10.16766/j.cnki.issn.1674-4152.001965

  • Caolu Community Health Service Center, Pudong New Area, Shanghai 201209, China

Funds:

 PWRs2017-31

  • Received Date: 2021-05-27
    Available Online: 2022-02-16
    Abstract
  •   Objective  This study aimed to investigate the relationship between blood cell parameters and non-alcoholic fatty liver disease (NAFLD) in the elderly with hypertension and provide scientific evidence for the prevention and control of NAFLD in elderly hypertensive patients.   Methods  The cluster sampling method was adopted to select elderly people aged over 60 years who were diagnosed with hypertension from April to July 2018 by taking the village or committee as a unit. After establishing community health examination files, physical examination and laboratory examination were conducted to collect blood cell parameters and other data. Multivariate logistic regression was used to analyse the relationship between blood cell parameters and NAFLD.   Results  The detection rate of NAFLD in elderly patients with hypertension was 63.29% (2 041/3 225). The level of absolute lymphocyte, leukomonocyte, absolute monocyte, absolute neutrophil count, white blood cell count, red blood cell count, haematocrit, haemoglobin, mean corpuscular haemoglobin concentration and platelet count in the NAFLD group was higher than that in the normal group (all P < 0.05). The level of neutrophile granulocyte, red blood cell distribution width and mean corpuscular volume in the NAFLD group was lower than that in the normal group (all P < 0.05). After adjusting for gender, age, BMI and fasting glucose, red blood cell distribution width was negatively associated with NAFLD, and absolute lymphocyte, absolute monocyte, haemoglobin and red blood cell count were positively associated with NAFLD (all P < 0.05).   Conclusion  Our results suggest that red cell distribution width, absolute lymphocyte, red blood count, absolute monocyte and haemoglobin were associated with NAFLD, which may provide a new way to prevent and control NAFLD in elderly hypertensive patients.

     

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    • References(20)
  • [1]
    余双彬, 俞梦璐, 陈曦, 等. 四川省绵阳市成人脂肪肝流行现况及其代谢异常情况分析[J]. 中国医学科学院学报, 2019, 41(3): 323-330. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYKX201903006.htm
    [2]
    LU Z Y, SHAO Z, LI Y L, et al. Prevalence of and risk factors for non-alcoholic fatty liver disease in a Chinese population: an 8-year follow-up study[J]. World J Gastroenterol, 2016, 22(13): 3663-3669. doi: 10.3748/wjg.v22.i13.3663
    [3]
    徐静远, 邵勇, 鲁晓岚, 等. 老年居民非酒精性脂肪性肝病的影响因素和死因分析[J]. 中华肝脏病杂志, 2019, 27(3): 204-209.
    [4]
    GOLABI P, PAIK J M, REDDY R, et al. Prevalence and long-term outcomes of non-alcoholic fatty liver disease among elderly individuals from the United States[J]. BMC Gastroenterol, 2019, 19(1): 56. doi: 10.1186/s12876-019-0972-6
    [5]
    帅建, 匡爱霞, 王忠莉, 等. 武汉某社区老年人非酒精性脂肪肝的流行病学特点及危险因素分析[J]. 武汉大学学报(医学版), 2019, 40(5): 796-800. https://www.cnki.com.cn/Article/CJFDTOTAL-HBYK201905021.htm
    [6]
    朱悦, 孙耕耘. 中性粒细胞/淋巴细胞比值及血小板相关指标与OSAS患者严重程度的相关性研究[J]. 中华全科医学, 2019, 17(3): 347-350, 474. https://www.cnki.com.cn/Article/CJFDTOTAL-SYQY201903003.htm
    [7]
    KOR C T, HSIEH Y P, CHANG C C, et al. The prognostic value of interaction between mean corpuscular volume and red cell distribution width in mortality in chronic kidney disease[J]. Sci Rep, 2018, 8(1): 11870. doi: 10.1038/s41598-018-19881-2
    [8]
    CHOI S H, KIM J H, LIM S, et al. Monocyte count as a predictor of cardiovascular mortality in older Korean people[J]. Age Ageing, 2017, 46(3): 433-438. doi: 10.1093/ageing/afw226
    [9]
    中国高血压防治指南(2018年修订版)[J]. 中国心血管杂志, 2019, 24(1): 24-56.
    [10]
    中华医学会肝脏病学分会脂肪肝和酒精性脂肪肝病学组. 非酒精性脂肪性肝病诊疗指南2010(修订版)[J]. 中华肝脏病杂志, 2010, 18(2): 163-166. https://www.cnki.com.cn/Article/CJFDTOTAL-YXQY201207005.htm
    [11]
    LI Y L, XING C Z, WEI M J, et al. Combining red blood cell distribution width (RDW-CV) and CEA predict poor prognosis for survival outcomes in colorectal cancer[J]. J Cancer, 2019, 10(5): 1162-1170. doi: 10.7150/jca.29018
    [12]
    王力炜, 杨文彬, 於涛, 等. 连云港农村地区高血压人群中红细胞分布宽度与血脂相关性研究[J]. 中华疾病控制杂志, 2016, 20(6): 568-571, 576. https://www.cnki.com.cn/Article/CJFDTOTAL-JBKZ201606008.htm
    [13]
    ZHOU W J, YANG J, ZHANG G, et al. Association between red cell distribution width-to-platelet ratio and hepatic fibrosis in nonalcoholic fatty liver disease: a cross-sectional study[J]. Medicine(Baltimore), 2019, 98(30): e16565. http://journals.lww.com/md-journal/Fulltext/2019/07260/Association_between_red_cell_distribution.57.aspx
    [14]
    刘安楠, 潘洁, 王蕾蕾, 等. 血红蛋白水平与非酒精性脂肪性肝病发生风险相关性队列研究[J]. 中华全科医师杂志, 2018, 17(2): 130-132. doi: 10.3760/cma.j.issn.1671-7368.2018.02.011
    [15]
    BAI C H, WU M S, OWAGA E, et al. Relationship between hemoglobin levels and risk for suspected non－alcoholic fatty liver in Taiwanese adults[J]. Clin J Physiol, 2014, 57(5): 286-294. http://europepmc.org/abstract/MED/25241989
    [16]
    张正怀, 杨志林. 外周血中性粒细胞与淋巴细胞比值在非酒精性脂肪肝诊断中的应用[J]. 检验医学与临床, 2016, 13(23): 3323-3324, 3328. doi: 10.3969/j.issn.1672-9455.2016.23.015
    [17]
    侯杰, 耿熠, 赵亚宁, 等. 外周血淋巴细胞绝对值和单核细胞绝对值的比值对胃癌患者预后的预测价值[J]. 癌症进展, 2019, 17(18): 2192-2195. https://www.cnki.com.cn/Article/CJFDTOTAL-AZJZ201918023.htm
    [18]
    刘奕婷, 王巍. 健康体检人群白细胞计数与非酒精性脂肪肝的关联性研究[J]. 实用预防医学, 2020, 27(1): 57-60. doi: 10.3969/j.issn.1006-3110.2020.01.015
    [19]
    MILLER M M, HENNINGER N, SŁOWIK A. Mean platelet volume and its genetic variants relate to stroke severity and one-year mortality[J]. Neurology, 2020, 95(9): e1153-e1162. doi: 10.1212/WNL.0000000000010105
    [20]
    HAN L Y, HAN T, NIE C Y, et al. Elevated mean platelet volume is associated with poor short-term outcomes in hepatitis B virus-related acute-on-chronic liver failure patients[J]. Clin Res Hepatol Gastroenterol, 2015, 39(3): 331-339. doi: 10.1016/j.clinre.2014.10.006
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