Volume 19 Issue 6
Jun.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(6): 1017-1021
WU Xian, WANG Hai-bo, LOU Chao-sheng, ZHANG Yin, YE Le-chi. Effect of Yiwei Fuzheng Decoction on Qi deficiency and blood stasis type precancerous lesion and its related mechanism[J]. Chinese Journal of General Practice, 2021, 19(6): 1017-1021. doi: 10.16766/j.cnki.issn.1674-4152.001974
Citation: WU Xian, WANG Hai-bo, LOU Chao-sheng, ZHANG Yin, YE Le-chi. Effect of Yiwei Fuzheng Decoction on Qi deficiency and blood stasis type precancerous lesion and its related mechanism[J]. Chinese Journal of General Practice, 2021, 19(6): 1017-1021. doi: 10.16766/j.cnki.issn.1674-4152.001974
shu

Effect of Yiwei Fuzheng Decoction on Qi deficiency and blood stasis type precancerous lesion and its related mechanism

doi: 10.16766/j.cnki.issn.1674-4152.001974

  • Department of General Surgery, Wenzhou Hospital of Traditional Chinese Medicine, Wenzhou, Zhejiang 325000, China

Funds:

 2015KYB245

  • Received Date: 2019-06-04
    Available Online: 2022-02-16
    Abstract
  •   Objective  To investigate the effect of Yiwei Fuzheng Decoction on qi deficiency and blood stasis precancerous lesion (PLGC) and its effect on the expression of gastric mucosal histone kinase B/rapamycin target protein (AKT/mTOR) pathway.  Methods  There were 88 patients with qi-deficiency and blood stasis type PLGC who were treated in our hospital from March 2017 to October 2018. The patients were divided into study group and control group according to the random number table method, and 44 cases in each group. Patients in the control group were treated with Weifuchun tablets. Patients in the study group were treated with Yiwei Fuzheng Decoction. The clinical efficacy, pathological score, clinical symptom score and adverse reactions of the two groups were compared. Serum tumor markers were detected by electrochemical chemilescence immunoassay, and the expressions of p-AKT and p-mTOR in gastric mucosal tissues before and after treatment were observed by immunohistochemistry.  Results  After treatment, the total effective rate of the study group (86.36%) was higher than that of the control group (68.18%, P < 0.05). Mucosal inflammation, inflammatory activity, gland atrophy, intestinal metaplasia, dysplasia and other pathological scores in the two groups were significantly reduced, and the pathological scores in the study group were lower than those in the control group (all P < 0.05). The symptom scores of patients in the two groups were significantly reduced after treatment, including full distension, stomachache, fatigue, poor appetite, loose stools in stool, and belching regurgitation, etc., and the pathological scores in the study group were all lower than those in the control group (all P < 0.05). After treatment, the levels of serum CEA, CA19-9 and CA125 in the study group were lower than those in the control group (all P < 0.05). After treatment, the positive expression rates of p-AKT and p-mTOR in gastric mucosa of the study group were lower than those in the control group (all P < 0.05). There was no obvious adverse reaction in both groups.  Conclusion  Yiwei Fuzheng Decoction may treat qi deficiency and blood stasis type PLGC by regulating AKT/mTOR pathway.

     

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