Volume 19 Issue 11
Nov.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(11): 1815-1818, 1835
JIANG Su-rong, CAO Ya-ru, WANG Ying-ying, WANG Xiao-yan, HONG Jian, GUO Yan. Correlation between 25-hydroxyvitamin D deficiency and heart failure with preserved ejection fraction in the elderly[J]. Chinese Journal of General Practice, 2021, 19(11): 1815-1818, 1835. doi: 10.16766/j.cnki.issn.1674-4152.002174
Citation: JIANG Su-rong, CAO Ya-ru, WANG Ying-ying, WANG Xiao-yan, HONG Jian, GUO Yan. Correlation between 25-hydroxyvitamin D deficiency and heart failure with preserved ejection fraction in the elderly[J]. Chinese Journal of General Practice, 2021, 19(11): 1815-1818, 1835. doi: 10.16766/j.cnki.issn.1674-4152.002174
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Correlation between 25-hydroxyvitamin D deficiency and heart failure with preserved ejection fraction in the elderly

doi: 10.16766/j.cnki.issn.1674-4152.002174

  • Department of Geriatric Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China

Funds:

 BJ18017

  • Received Date: 2021-03-23
    Available Online: 2022-02-15
    Abstract
  •   Objective  To investigate the correlation between serum 25-hydroxyvitamin D [25(OH)D] deficiency and heart failure with preserved ejection fraction in the elderly.   Methods  A total of 219 elderly patients treated in the Department of Geriatric Cardiology of the First Affiliated Hospital of Nanjing Medical University from January 2019 to December 2020 were enrolled and divided into the HFpEF group (n=118) and control group (n=101). General data, routine biochemical index results, 25(OH)D, NT-ProBNP and echocardiography parameters of all patients were collected and compared. The correlation between serum 25(OH)D level and echocardiographic parameters was analysed, and the risk factors of HFpEF were analysed by multivariate stepwise logistic regression.   Results  The level of 25(OH)D in the HFpEF group [(37.58±12.92) nmol/L] was significantly lower than that in the control group [(60.82±13.61) nmol/L, P < 0.001]. The HFpEF group had higher echocardiographic parameters such as LAD, LVDd, LVDs, IVS, LVMI, E/e', LAVI, TRV and PASP and lower LVEF and average e' compared with the control group (all P < 0.05). Spearman correlation analysis showed that the 25(OH)D level was negatively correlated with LAD, IVS, LVPW, LVMI, E/e', LAVI, TRV, PASP and NT-proBNP and was positively correlated with average e' (all P < 0.05). Multivariate stepwise logistic regression analysis showed that 25(OH)D level was an independent influence factor for HFpEF in the elderly (OR=0.814, 95% CI: 0.723-0.916, P=0.001).   Conclusion  25(OH)D deficiency is related to HFpEF and can be an independent risk factor for elderly HFpEF.

     

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