Volume 19 Issue 11
Nov.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(11): 1858-1860,1867
LUO Hua-fang, LIU Zhen-qiang. Effect of tanshinone capsule combined with conventional western medicine on acne vulgaris[J]. Chinese Journal of General Practice, 2021, 19(11): 1858-1860,1867. doi: 10.16766/j.cnki.issn.1674-4152.002185
Citation: LUO Hua-fang, LIU Zhen-qiang. Effect of tanshinone capsule combined with conventional western medicine on acne vulgaris[J]. Chinese Journal of General Practice, 2021, 19(11): 1858-1860,1867. doi: 10.16766/j.cnki.issn.1674-4152.002185
shu

Effect of tanshinone capsule combined with conventional western medicine on acne vulgaris

doi: 10.16766/j.cnki.issn.1674-4152.002185
  • 1.

    Pharmacy Department, the 904th Hospital of PLA Joint Logistics Support Force, Wuxi, Jiangsu 214000, China

Funds:

 H2017034

  • Received Date: 2021-03-29
    Available Online: 2022-02-15
    Abstract
  •   Objective  To explore the clinical effect of tanshinone capsule combined with isotretinoin soft capsule and clarithromycin tablets in the treatment of acne vulgaris.  Methods  A total of 137 cases of acne vulgaris treated in the 904th Hospital of PLA Joint Logistics Support Force from January 2019 to December 2020 were selected and randomly divided into control group (n=68, isotretinoin soft capsule and clarithromycin tablets) and study group (n=69, tanshinone capsule combined with isotretinoin soft capsule and clarithromycin tablets). The curative effect, security and the skin lesion score, inflammatory factors and humoral immune indexes were compared before and after treatment between both groups.  Results  The total effective rate of the study group (82.61%) was higher than that of the control group (66.18%, P < 0.05). After treatment, the IgG [(8.12±1.28) g/L vs.(12.08±1.29) g/L], IL-4 [(19.13±2.39) ng/L vs.[(25.67±3.36) ng/L], IL-17 [(1.98±0.33) ng/L vs.(2.47±0.41) ng/L], TNF-α [(28.67±4.52) ng/L vs.(36.28±5.46) ng/L] and the scores of pustules [(1.51±0.35) points vs. (1.89±0.46) points], papules [(1.34±0.22) points vs. (1.73±0.41) points], acne [(1.31±0.28) points vs. (1.79±0.32) points], nodules and cysts [(1.24±0.26) points vs. (1.69±0.22) points] were lower than those in the control group (P < 0.05). There was no difference in the incidence of adverse reactions between the two groups (P>0.05).  Conclusion  Tanshinone capsule combined with isotretinoin soft capsule and clarithromycin tablets can effectively treat acne vulgaris, and improve the immune function to a certain extent.

     

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